Synthesis of 1,1,1-Tris(boronates) from Vinylarenes by Co-Catalyzed Dehydrogenative Borylations–Hydroboration

The selective preparation of 1,1,1-tris­(boronates) from vinylarenes and bis­(pinacolato)­diboron is described. The reactions occur at ambient temperature with excellent selectivity, high yields, and good functional group tolerance. Mechanistic studies suggest that Co­(I)-catalyzed double dehydrogenative borylations generate a 1,1-diborylalkene intermediate, which undergoes hydroboration with pinacolborane formed <i>in situ</i> to yield 1,1,1-tris­(boronate)

Synthesis of 1,1,1-Tris(boronates) from Vinylarenes by Co-Catalyzed Dehydrogenative Borylations–Hydroboration

The selective preparation of 1,1,1-tris­(boronates) from vinylarenes and bis­(pinacolato)­diboron is described. The reactions occur at ambient temperature with excellent selectivity, high yields, and good functional group tolerance. Mechanistic studies suggest that Co­(I)-catalyzed double dehydrogenative borylations generate a 1,1-diborylalkene intermediate, which undergoes hydroboration with pinacolborane formed <i>in situ</i> to yield 1,1,1-tris­(boronate)

Thermal, Catalytic Conversion of Alkanes to Linear Aldehydes and Linear Amines

Alkanes, the main constituents of petroleum, are attractive feedstocks for producing value-added chemicals. Linear aldehydes and amines are two of the most important building blocks in the chemical industry. To date, there have been no effective methods for directly converting <i>n</i>-alkanes to linear aldehydes and linear amines. Here, we report a molecular dual-catalyst system for production of linear aldehydes via regioselective carbonylation of <i>n</i>-alkanes. The system is comprised of a pincer iridium catalyst for transfer-dehydrogenation of the alkane using <i>t</i>-butylethylene or ethylene as a hydrogen acceptor working sequentially with a rhodium catalyst for olefin isomerization-hydroformylation with syngas. The system exhibits high regioselectivity for linear aldehydes and gives high catalytic turnover numbers when using ethylene as the acceptor. In addition, the direct conversion of light alkanes, <i>n</i>-pentane and <i>n</i>-hexane, to siloxy-terminated alkyl aldehydes through a sequence of Ir/Fe-catalyzed alkane silylation and Ir/Rh-catalyzed alkane carbonylation, is described. Finally, the Ir/Rh dual-catalyst strategy has been successfully applied to regioselective alkane aminomethylation to form linear alkyl amines

Nicorandil in Patients with Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis

<div><p>Background</p><p>Nicorandil, as an adjunctive therapy with primary percutaneous coronary intervention (PCI), had controversial benefits in cardioprotection in patients with acute myocardial infarction (AMI).</p> <p>Methods and Results</p><p>We performed a systematic review of randomized controlled trials (RCTs) comparing treatment with nicorandil prior to reperfusion therapy with control (placebo or no nicorandil) in patients who suffered from AMI and performed primary PCI. PubMed, EMBASE and CENTRAL databases and other sources were searched without language and publication restriction. 14 trials involving 1680 patients were included into this meta-analysis. Nicorandil significantly reduced the incidence of thrombolysis in myocardial infarction (TIMI) flow grade ≤2 (risk ratio [RR], 0.57; 95% confidence interval [CI]: 0.42 to 0.79), the Timi frame count (TFC) (mean difference [MD], -5.19; 95% CI: -7.13 to -3.26), increased left ventricular ejection fraction (LVEF) (%) (MD, 3.08; 95% CI: 0.79 to 5.36), and reduced the incidence of ventricular arrhythmia (RR, 0.53; 95% CI: 0.37 to 0.76) and congestive heart failure (CHF) (RR, 0.41; 95% CI: 0.22 to 0.75). No difference in the pear creatine kinase (CK) value (MD, -290.19; 95% CI: -793.75 to 213.36) or cardiac death (RR, 0.39; 95% CI: 0.09 to 1.67) was observed.</p> <p>Conclusions</p><p>Nicorandil prior to reperfusion is associated with improvement of coronary reflow as well as suppression of ventricular arrhythmia, and further improves left ventricular function in patients who suffered from AMI and underwent primary PCI. But the definite clinical benefits of nicorandil were not found, which may be due to the small sample size of the selected studies.</p> </div

Manganese-Catalyzed Asymmetric Hydrosilylation of Aryl Ketones

We disclose the synthesis of a series of manganese complexes of chiral iminopyridine oxazoline ligands and their application in the first manganese-catalyzed asymmetric ketone hydrosilylations. The most sterically hindered manganese catalyst bearing two CH­(Ph)₂ groups at the 2,6-ortho positions of the imino aryl ring and a <i>t</i>Bu group on the oxazoline ring furnishes the secondary alcohols in high enantioselectivities and yields

RR of the Incidence of TIMI Flow Grade ≤ 2.

<p>Forest plot of RR (with 95% CI) for TIMI flow grade ≤ 2 in patients receiving nicorandil compared with those receiving no nicorandil. Significant reduction in TIMI flow grade ≤ 2 (RR: 0.57; 95% CI: 0.42 to 0.79; p=0.0006) was observed in nicorandil group. CI = confidence interval; RR = risk ratio; TIMI = thrombolysis in myocardial infarction.</p

Risk of Bias Summary.

<p>Risk of Bias Summary.</p

MD of LVEF.

<p>Forest plot of MD (with 95% CI) for LVEF in patients receiving nicorandil compared with those receiving no nicorandil. Significant increase in LVEF (MD: 3.08; 95% CI: 0.79 to 5.36; p=0.008) was observed in nicorandil group. CI = confidence interval; LVEF = left ventricular ejection fraction; MD = mean difference.</p

Cobalt-Catalyzed Enantioselective Hydroboration of 1,1-Disubstituted Aryl Alkenes

We report the synthesis of cobalt complexes of novel iminopyridine–oxazoline (IPO) ligands and their application to the asymmetric hydroboration of 1,1-disubstituted aryl alkenes. The new catalysts afforded α-alkyl-β-pinacolatoboranes with exclusive regioselectivity in high yields with up to 99.5% ee. Furthermore, we have applied this method to an efficient synthesis of naproxen

Funnel Plot for the Incidence of TIMI Flow Grade ≤ 2.

<p>RR = risk ratio; SE = standard error.</p