Rh-Catalyzed Asymmetric Hydrogenation of Cyclic α‑Dehydroamino Ketones

Catalyzed by a rhodium complex of P-stereogenic diphosphine trichickenfootphos, five-membered cyclic α-dehydroamino ketones bearing endocyclic acyl and endocyclic vinyl groups were hydrogenated to give chiral α-amino ketones with quantitative conversions and excellent enantioselectivities

Rh-Catalyzed One-Pot Sequential Asymmetric Hydrogenation of α‑Dehydroamino Ketones for the Synthesis of Chiral Cyclic <i>trans</i>-β-Amino Alcohols

Catalyzed by a rhodium complex of P-stereogenic diphosphine ligand (<i>R</i>)-2-<i>tert</i>-butylmethylphosphino-3-(di-<i>tert</i>-butylphosphino)­quinoxaline ((<i>R</i>)-<b>3H-QuinoxP</b>*), five-membered cyclic α-dehydroamino ketones bearing endocyclic vinyl and endocyclic keto-carbonyl groups were sequentially hydrogenated to give chiral cyclic <i>trans</i>-β-amino alcohols with two contiguous stereocenters in quantitative conversions, excellent enantioselectivities and good diastereoselectivities

Three-Hindered Quadrant Phosphine Ligands with an Aromatic Ring Backbone for the Rhodium-Catalyzed Asymmetric Hydrogenation of Functionalized Alkenes

The three-hindered quadrant phosphine ligands (<i>R</i>)-1-<i>tert</i>-butylmethylphosphino-2-(di-<i>tert</i>-butylphosphino)­benzene ((<i>R</i>)-3H-BenzP*) and (<i>R</i>)-2-<i>tert</i>-butylmethylphosphino-3-(di-<i>tert</i>-butylphosphino)­quinoxaline ((<i>R</i>)-3H-QuinoxP*) exhibited good to excellent enantioselectivities in the rhodium-catalyzed asymmetric hydrogenation of selected dehydroamino acid derivatives, enamides, and ethenephosphonates

Chemoselective Transfer Hydrogenation of α,β-Unsaturated Ketones Catalyzed by Pincer-Pd Complexes Using Alcohol as a Hydrogen Source

A pincer-Pd complex was utilized in the chemoselective transfer hydrogenation of α,β-unsaturated ketones using <i>n-</i>BuOH as a hydrogen source and solvent. Good to excellent yields were obtained for various substrates even with reducible groups. Based on deuterium-labeling experiments, the reaction mechanism is proposed to occur via a pincer-Pd-hydride intermediate

Chemoselective Transfer Hydrogenation of α,β-Unsaturated Ketones Catalyzed by Pincer-Pd Complexes Using Alcohol as a Hydrogen Source

A pincer-Pd complex was utilized in the chemoselective transfer hydrogenation of α,β-unsaturated ketones using <i>n-</i>BuOH as a hydrogen source and solvent. Good to excellent yields were obtained for various substrates even with reducible groups. Based on deuterium-labeling experiments, the reaction mechanism is proposed to occur via a pincer-Pd-hydride intermediate

Rh-Catalyzed Asymmetric Hydrogenation of β‑Branched Enol Esters for the Synthesis of β‑Chiral Primary Alcohols

An asymmetric hydrogenation of β-branched enol esters has been developed for the first time, providing a new route for the synthesis of β-chiral primary alcohols. Using a (<i>S</i>)-SKP-Rh complex bearing a large bite angle and enol ester substrates possessing an <i>O</i>-fomyl directing group, the desired products were obtained in quantitative yields and with excellent enantioselectivities

Chemoselective Transfer Hydrogenation of α,β-Unsaturated Ketones Catalyzed by Pincer-Pd Complexes Using Alcohol as a Hydrogen Source

A pincer-Pd complex was utilized in the chemoselective transfer hydrogenation of α,β-unsaturated ketones using <i>n-</i>BuOH as a hydrogen source and solvent. Good to excellent yields were obtained for various substrates even with reducible groups. Based on deuterium-labeling experiments, the reaction mechanism is proposed to occur via a pincer-Pd-hydride intermediate

Sequence-Dependent T:G Base Pair Opening in DNA Double Helix Bound by Cren7, a Chromatin Protein Conserved among Crenarchaea - Fig 2

<p><b>Comparison between the classic T:G wobble base pairs (A-C) and the open T:G base pair (D).</b> The T:G base pairs are shown in stick view with the carbon, nitrogen, phosphorus and oxygen atoms on the coordinating chains shown in grey, blue, orange and red, respectively.</p

Kinetic characterization of the binding of Cren7 to mismatched or matched DNA.

<p>Cren7 was injected over immobilized DNAs. Sensorgrams are shown with the KD values labeled. RU, response units.</p

DNA helical parameters of the Cren7-DNA complexes.

<p>DNA helical parameters of the Cren7-DNA complexes.</p