Funnel plot for the random-effects between-group meta-analysis on blood glutamate levels in persons with ASD and controls.

<p>Funnel plot for the random-effects between-group meta-analysis on blood glutamate levels in persons with ASD and controls.</p

Forest plot for the random-effects between-group meta-analysis of blood glutamate levels in persons with ASD and controls.

<p>Forest plot for the random-effects between-group meta-analysis of blood glutamate levels in persons with ASD and controls.</p

Characteristics of the twelve studies included in the meta-analysis.

<p>Characteristics of the twelve studies included in the meta-analysis.</p

Flow chart of the study selection process for eligible studies in the systematic review.

<p><i>From</i>: Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group (2009). <i>Preferred Reporting I</i>tems for <i>S</i>ystematic Reviews and <i>M</i>eta-<i>A</i>nalyses: The PRISMA Statement. PLoS Med 6(6): e1000097. doi: <a href="10.1371/journal.pmedl000097" target="_blank">10.1371/journal.pmedl000097</a> For more information, visit <a href="http://www.prisma-statement.org" target="_blank">www.prisma-statement.org</a>.</p

Quality assessment of the included studies by the Newcastle–Ottawa Scale.

<p>Quality assessment of the included studies by the Newcastle–Ottawa Scale.</p

Summary of the results of blood glutamate levels in persons with ASD and controls.

<p>Summary of the results of blood glutamate levels in persons with ASD and controls.</p

Meta-regression of blood glutamate levels in persons with ASD and controls.

<p>Meta-regression of blood glutamate levels in persons with ASD and controls.</p

One-Step Fabrication of 3D Nanohierarchical Nickel Nanomace Array To Sinter with Silver NPs and the Interfacial Analysis

Three-dimensional (3D) nanohierarchical Ni nanomace (Ni NM) array was fabricated on copper substrate by only one step with electroplating method, the unique structure was covered with Au film (Ni/Au NM) without changing its morphology, and in the following step, it was sintered with silver nanoparticle (Ag NP) paste. The structure of the Ni NM array and its surface morphology were characterized by X-ray diffraction, scanning electron microscope (SEM), and atomic force microscope. The sintered interface was investigated by SEM, transmission electron microscopy, and energy-dispersive X-ray spectroscopy to analyze the sintering mechanism. The results showed that a metallurgical bond was successfully achieved at 250 °C without any gas or vacuum shield and extra pressure. The Cu substrate with Ni/Au NM array was able to join with the Ag NP paste without obvious voids. Due to the compatible chemical potential between Ag NPs and Ni/Au NM array, the Au element was able to diffuse into the Ag layer with about 800 nm distance. Based on the excellent 3D nanohierarchical structure, the shear strength of Ni/Au NM array was 6 times stronger than the flat Ni/Au coated substrate. It turned out that the substrate surface played a crucial role in improving the shear strength and sintering efficiency. The 3D Ni NM array had achieved an excellent bonding interface and had great potential application in the microelectronics packaging field

Preparation of a High-Strength Hydrogel with Slidable and Tunable Potential Functionalization Sites

A hydrogel with tunable potential functionalization sites has been successfully prepared. As potential functionalization sites, (2-hydroxy­propyl)-α-CDs (Hy-α-CDs) were introduced into the network of tetrahedron-like poly­(ethylene glycol) (tetra-PEG) gel through supramolecular chemistry. In the stage of complexation, poly-<i>pseudo</i>-rotaxane consisting of tetra-PEG macromonomer and Hy-α-CD formed in pregel solution. The dynamic complexation process and the structure of the poly-<i>pseudo</i>-rotaxane were investigated by NMR experiment. In the stage of gelation, some cross-linking reactions were completed through click chemistry. The structures and mechanical properties of the resultant hydrogels were characterized by ATR-FTIR, XPS, SEM, and compression test in detail. The number of Hy-α-CD introduced into the hydrogel is related closely to the structure of the poly-<i>pseudo</i>-rotaxane and can be controlled easily by tuning the feed ratio. Anthracene as an example of function was introduced into the hydrogel through Hy-α-CD to preliminarily demonstrate the validity of the potential functionalization site in the last, and the hydrogel also has the capacity for further diverse functionalization

Image2_Transcriptome analyses reveal new insights on key determinants of perineural invasion in high-grade serous ovarian cancer.TIF

Perineural invasion (PNI) is a pathological feature of many cancers associated with poor outcomes, metastases, and recurrence. In relation to ovarian cancer (OC), there is no information about PNI’s role and mechanisms. Our study found that patients with PNI-positive symptoms had significantly shorter overall survival (OS) time than patients with PNI-negative symptoms. Multivariate analyses demonstrated that PNI represented a substantial independent prognostic factor in OC patients. At the transcriptome level, it is noteworthy that PNI positivity was negatively correlated with the degree of infiltration of immune killer cells in OC tumor tissues, including macrophage, central memory CD4 T-cell, natural killer cells, monocyte, and central memory CD4 T-cell. The results of this study revealed that TAS2Rs proteins were markedly upregulated in PNI-positive OC tissues and predicted poor prognoses. Moreover, Immunohistochemical analysis demonstrated that the TAS2R10 protein was associated with poor prognoses and PNI in OC. Consequently, we found for the first time that PNI was a powerful predictor of poor prognosis in OC and analyzed its expression pattern and some preliminary biochemical characterization, providing new clues for guiding clinical prevention and treatment of OC.</p