Case-control analysis on non-synonymous <i>PALB2</i> variants.

<p>Case-control analysis on non-synonymous <i>PALB2</i> variants.</p

Co-segregation analysis of <i>PALB2</i> variants in two high-risk CMM families.

<p>Individuals that have melanoma (MM) are represented by black circles (female) and black boxes (male). The age of diagnosis of each cancer is indicated in brackets. A line through a symbol indicates that the person is deceased. Individuals carrying a <i>PALB2</i> mutation are indicated by an ‘M’, while those wild-type for the variant are indicated by ‘WT’. Other cancer types are also indicated on the pedigree. Unaffected siblings are represented by a diamond with the number indicating the number of siblings. The arrow indicates the proband in each family.</p

<i>PALB2</i> variants detected through Sanger sequencing and exome sequencing.

<p>*European American population.</p><p>na is not available.</p