Radio Sources Segmentation and Classification with Deep Learning

Modern large radio continuum surveys have high sensitivity and resolution, and can resolve previously undetected extended and diffuse emissions, which brings great challenges for the detection and morphological classification of extended sources. We present HeTu-v2, a deep learning-based source detector that uses the combined networks of Mask Region-based Convolutional Neural Networks (Mask R-CNN) and a Transformer block to achieve high-quality radio sources segmentation and classification. The sources are classified into 5 categories: Compact or point-like sources (CS), Fanaroff-Riley Type I (FRI), Fanaroff-Riley Type II (FRII), Head-Tail (HT), and Core-Jet (CJ) sources. HeTu-v2 has been trained and validated with the data from the Faint Images of the Radio Sky at Twenty-one centimeters (FIRST). We found that HeTu-v2 has a high accuracy with a mean average precision ($AP_{\rm @50:5:95}$) of 77.8%, which is 15.6 points and 11.3 points higher than that of HeTu-v1 and the original Mask R-CNN respectively. We produced a FIRST morphological catalog (FIRST-HeTu) using HeTu-v2, which contains 835,435 sources and achieves 98.6% of completeness and up to 98.5% of accuracy compared to the latest 2014 data release of the FIRST survey. HeTu-v2 could also be employed for other astronomical tasks like building sky models, associating radio components, and classifying radio galaxies

Dynamics and design of space nets for orbital capture

This book covers the topics of theoretical principles, dynamics model and algorithm, mission analysis, system design and experimental studies of space nets system, aiming to provide an initial framework in this field and serve as a ready reference for those interested. Space nets system represents a forefront field in future development of aerospace technologies. However, it involves new challenges and problems such as nonlinear and distorted nets structure, complex rigid flexible coupling dynamics, orbital transfer of space flexible composite and dynamics control. Currently, no comprehensive books on space nets dynamics and design are available, so potential readers can get to know the working mechanism, dynamics elements, and mission design of the space nets system from a Chinese perspective

The role of organoids in cancer research

Abstract Organoids are established through in vitro 3D culture, and they can mimic the structure and physiological functions of organs or tissues in vivo. Organoids have attracted much attention in recent years. They can provide a reliable technology platform for cancer research and treatment and are a valuable preclinical model for academic research and personalized medicine. A number of studies have confirmed that organoids have great application prospects in new drug development, drug screening, tumour mechanism research, and precision medicine. In this review, we mainly focus on recent advances in the application of organoids in cancer research. We also discussed the opportunities and challenges facing organoids, hoping to indicate directions for the development of organoids in the future

Ontogeny of Excitatory Spinal Neurons Processing Distinct Somatic Sensory Modalities

Spatial and temporal cues govern the genesis of a diverse array of neurons located in the dorsal spinal cord, including dI1-dI6, dIL(A), and dIL(B) subtypes, but their physiological functions are poorly understood. Here we generated a new line of conditional knock-out (CKO) mice, in which the homeobox gene Tlx3 was removed in dI5 and dIL(B) cells. In these CKO mice, development of a subset of excitatory neurons located in laminae I and II was impaired, including itch-related GRPR-expressing neurons, PKCγ-expressing neurons, and neurons expressing three neuropeptide genes: somatostatin, preprotachykinin 1, and the gastrin-releasing peptide. These CKO mice displayed marked deficits in generating nocifensive motor behaviors evoked by a range of pain-related or itch-related stimuli. The mutants also failed to exhibit escape response evoked by dynamic mechanical stimuli but retained the ability to sense innocuous cooling and/or warm. Thus, our studies provide new insight into the ontogeny of spinal neurons processing distinct sensory modalities

UV-Light-Induced Morphological Transformation of Spiropyran Assemblies from Irregular Sheet-like Structures to Nanospheres

Studies on self-assembling systems with a controllable morphology responding to light stimulation are significant for revealing the process and mechanism of assembly. Here, a molecule of spiropyran derivative (SP) possessing photoresponsive assembly morphology is constructed. SP self-assembles into irregular sheet-like structures whose morphology can be significantly transformed into regular nanospheres under continuous ultraviolet light stimulation. The UV–vis absorption spectra indicate that 56% of SP are isomerized from closed-ring form (SPC) to open-ring form (SPO) with color changes from colorless to magenta. Furthermore, theoretical calculations demonstrate that SPO-SPO aggregates possess stronger van der Waals forces than do SPC–SPC aggregates and tend to form stable intermediates combined with SPO isomers. Therefore, the isomerization of SP from SPC to SPO and the differences in intermolecular interactions are important factors in the morphological transition. Our study provides an efficient strategy to modulate the assembled morphology, which holds great promise to be applied in the field of smart materials

Macroglia-derived thrombospondin 2 regulates alterations of presynaptic proteins of retinal neurons following elevated hydrostatic pressure

<div><p>Many studies on retinal injury and repair following elevated intraocular pressure suggest that the survival ratio of retinal neurons has been improved by various measures. However, the visual function recovery is far lower than expected. The homeostasis of retinal synapses in the visual signal pathway is the key structural basis for the delivery of visual signals. Our previous studies found that complicated changes in the synaptic structure between retinal neurons occurred much earlier than obvious degeneration of retinal ganglion cells in rat retinae. The lack of consideration of these earlier retinal synaptic changes in the rescue strategy may be partly responsible for the limited visual function recovery with the types of protective methods for retinal neurons used following elevated intraocular pressure. Thus, research on the modulatory mechanisms of the synaptic changes after elevated intraocular pressure injury may give new light to visual function rescue. In this study, we found that thrombospondin 2, an important regulator of synaptogenesis in central nervous system development, was distributed in retinal macroglia cells, and its receptor α2δ-1 was in retinal neurons. Cell cultures including mixed retinal macroglia cells/neuron cultures and retinal neuron cultures were exposed to elevated hydrostatic pressure for 2 h. The expression levels of glial fibrillary acidic protein (the marker of activated macroglia cells), thrombospondin 2, α2δ-1 and presynaptic proteins were increased following elevated hydrostatic pressure in mixed cultures, but the expression levels of postsynaptic proteins were not changed. SiRNA targeting thrombospondin 2 could decrease the upregulation of presynaptic proteins induced by the elevated hydrostatic pressure. However, in retinal neuron cultures, elevated hydrostatic pressure did not affect the expression of presynaptic or postsynaptic proteins. Rather, the retinal neuron cultures with added recombinant thrombospondin 2 protein upregulated the level of presynaptic proteins. Finally, gabapentin decreased the expression of presynaptic proteins in mixed cultures by blocking the interaction of thrombospondin 2 and α2δ-1. Taken together, these results indicate that activated macroglia cells may participate in alterations of presynaptic proteins of retinal neurons following elevated hydrostatic pressure, and macroglia-derived thrombospondin 2 may modulate these changes via binding to its neuronal receptor α2δ-1.</p></div

Cell compositions in the mixed cultures and retinal neuron cultures.

<p>(A) Double immunofluorescence Map2/GFAP, CD11b/DAPI staining in mixed cultures. (B) Double immunofluorescence Map2/DAPI staining in retinal neuron cultures. Scale bar = 50 μm.</p

Immunofluorescence for the localization of TSP2 and α2δ-1.

<p>(A) Localization of TSP2 was identified by TSP2/GFAP co-staining. (B) Localization of α2δ-1 was identified by α2δ-1/Map2 co-staining. Scale bar = 50 μm.</p