309 research outputs found
Larger Thyroid Volume and Adequate Iodine Nutrition in Chinese Schoolchildren: Local Normative Reference Values Compared with WHO/IGN
Association between an Impaired Bone Marrow Vascular Microenvironment and Prolonged Isolated Thrombocytopenia after Allogeneic Hematopoietic Stem Cell Transplantation
AbstractProlonged isolated thrombocytopenia (PT) is a serious complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, it remains unclear whether abnormalities of the bone marrow (BM) microenvironment are involved in the pathogenesis of PT. This prospective, nested case-control study included 20 patients with PT, 40 matched patients with good graft function (GGF) after allo-HSCT, and 16 healthy donors (HDs). Cellular elements of the BM microenvironment, including BM endothelial cells (BMECs), perivascular cells, and endosteal cells, were analyzed via flow cytometry and via hematoxylin-eosin and immunohistochemical staining in situ. Moreover, stromal-derived factor 1 (SDF-1) and vascular endothelial growth factor (VEGF) were measured in the plasma of BM via an enzyme-linked immunosorbent assay. No significant differences in endosteal cells (15 per high-power field [hpf] versus 16 per hpf versus 20 per hpf, P > .05) were demonstrated among the patients with PT, GGF, and the HDs. The PT patients exhibited remarkable decreases in cellular elements of the vascular microenvironment, including BMECs (.01% versus .18% versus .20%, PÂ <Â .0001) and perivascular cells (.01% versus .12% versus .13%, PÂ <Â .0001), compared with the GGF allo-HSCT recipients and the HDs, respectively. Moreover, significantly lower levels of SDF-1 (3163 pg/mL versus 3928 pg/mL, PÂ = .0002) and VEGF (56 pg/mL versus 123 pg/mL, PÂ <Â .0001) were found in the BM plasma of the PT patients compared with the BM of the GGF patients. A multivariate analysis revealed that BMECs (odds ratio [OR]Â =Â 171.57, PÂ = .002) and cytomegalovirus infection after HSCT (ORÂ =Â 4.35, PÂ = .009) were independent risk factors for PT. Our data suggested that an impaired BM vascular microenvironment and megakaryocyte-active factors may contribute to the occurrence of PT after HSCT
Nearly scale-invariant power spectrum and quantum cosmological perturbations in the gravity’s rainbow scenario
Partial Wave Analysis of
A partial wave analysis of in
decay is presented using a sample of 14 million
events accumulated by the BES II detector. The data are fitted to
the sum of relativistic covariant tensor amplitudes for intermediate resonant
decay modes. From the fit, significant contributions to decays from
the channels , , ,
, , , and are found. Flavor-SU(3)-violating
asymmetry is observed. Values obtained for the masses and
widths of the resonances , , , and
are presented.Comment: 16 pages, 9 figures, and 4 table
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