The effect of octreotide on spontaneous contractions of small intestine from ANP rats.

<p>The contractile activities were normal in control rats, but were abnormal and variable in ANP rats (<i>A</i>). The tendency of decline in amplitude of spontaneous ileal contractions of ANP+saline rats at 48 h was considered to be significant, compared with that in the control+saline rats(*; <i>P</i> = .015; n = 8; <i>B</i>). Compared with the corresponding ANP+saline group, the amplitude of contractions at 24 h and 48 h were significantly higher in the ANP+octreotide groups (24 h, **, <i>P</i> = .001; 48 h, *, <i>P</i> = .028; n = 8; <i>B</i>). No difference was observed between the 2 groups at the 72 h (<i>P</i>>.05, <i>B</i>). Data are expressed as means ± SEM. (*, <i>P</i><.05; **, <i>P</i><.01).</p

Western blot analysis of nNOS and CHAT.

<p><i>A</i> shows relative protein expression of nNOS obtained by densitometric analysis normalized to GAPDH. The predicted molecular weights are indicated by arrows. A drastic difference in protein expression of nNOS between the ANP+saline and ANP+octreotide groups was observed at 48 h (**; <i>P</i> = .001; n = 5, <i>C</i>). The molecular weight of the lower band corresponds well with the molecular weight of nNOS-ß, a splice variant of nNOS (Ld: protein ladder). <i>B</i> shows representative images from CHAT and GAPDH blots. The reduction of the CHAT-IR band density in the ANP+saline rats was more evident than in the ANP+octreotide rats at 24 h, ( <i>P</i> = .057; n = 5, <i>D</i>). Data are expressed as means ± SEM. (*, <i>P</i><.05; **, <i>P</i><.01).</p

Table_1_The status quo of short videos as a health information source of Helicobacter pylori: a cross-sectional study.DOCX

BackgroundHealth education about Helicobacter pylori (H. pylori) is one of the most effective methods to prevent H. pylori infection and standardize H. pylori eradication treatment. Short videos enable people to absorb and remember information more easily and are an important source of health education. This study aimed to assess the information quality of H. pylori-related videos on Chinese short video-sharing platforms.MethodsA total of 242 H. pylori-related videos from three Chinese short video-sharing platforms with the most users, TikTok, Bilibili, and Kwai, were retrieved. The Global Quality Score (GQS) and the modified DISCERN tool were used to assess the quality and content of videos, respectively. Additionally, comparative analyzes of videos based on different sources and common H. pylori issues were also conducted.ResultsThe median GQS score and DISCERN score was 2 for H. pylori-related videos analyzed in this study. Non-gastroenterologists posted the most H. pylori-related videos (136/242, 56.2%). Videos from gastroenterologists (51/242, 21.0%) had the highest GQS and DISCERN scores, with a median of 3. Few videos had content on family-based H. pylori infection control and management (5.8%), whether all H. pylori-positive patients need to undergo eradication treatment (27.7%), and the adverse effects of H. pylori eradication therapy (16.1%).ConclusionGenerally, the content and quality of the information in H. pylori-related videos were unsatisfactory, and the quality of the video correlated with the source of the video. Videos from gastroenterologists provided more correct guidance with higher-quality information on the prevention and treatment of H. pylori infection.</p

MCT increases mitochondrial biogenesis and metabolism under high temperature.

<p>Gene expression (A) and protein (B) levels for mitochondrial biogenesis and metabolism markers in the skeletal muscle. C: quantification of the immunoblot. ** p<0.01, *** P<0.001.</p

Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism

<div><p>Medium Chain Triglycerides (MCT) is a dietary supplement and usually used along with medications for treating food absorption disorders including diarrhea, steatorrhea and liver disease. It has been shown that MCT plays a role in lowering weight, and decreasing metabolic syndrome, abdominal obesity and inflammation. However, it is still unknown whether MCT enhances exercise endurance. Here, we demonstrated that MCT containing diet improves high temperature induced exercise performance impairment. We found that MCT up-regulates the expression and protein levels of genes involved in mitochondrial biogenesis and metabolism. Further investigation demonstrated that the increased mitochondrial biogenesis and metabolism is mediated through the activation of Akt and AMPK signaling pathways and inhibition of TGF-β signaling pathway. Collectively, our findings indicate a beneficial effect of dietary MCT in exercise performance through the increase of mitochondrial biogenesis and metabolism.</p></div

Table_2_The status quo of short videos as a health information source of Helicobacter pylori: a cross-sectional study.DOCX

BackgroundHealth education about Helicobacter pylori (H. pylori) is one of the most effective methods to prevent H. pylori infection and standardize H. pylori eradication treatment. Short videos enable people to absorb and remember information more easily and are an important source of health education. This study aimed to assess the information quality of H. pylori-related videos on Chinese short video-sharing platforms.MethodsA total of 242 H. pylori-related videos from three Chinese short video-sharing platforms with the most users, TikTok, Bilibili, and Kwai, were retrieved. The Global Quality Score (GQS) and the modified DISCERN tool were used to assess the quality and content of videos, respectively. Additionally, comparative analyzes of videos based on different sources and common H. pylori issues were also conducted.ResultsThe median GQS score and DISCERN score was 2 for H. pylori-related videos analyzed in this study. Non-gastroenterologists posted the most H. pylori-related videos (136/242, 56.2%). Videos from gastroenterologists (51/242, 21.0%) had the highest GQS and DISCERN scores, with a median of 3. Few videos had content on family-based H. pylori infection control and management (5.8%), whether all H. pylori-positive patients need to undergo eradication treatment (27.7%), and the adverse effects of H. pylori eradication therapy (16.1%).ConclusionGenerally, the content and quality of the information in H. pylori-related videos were unsatisfactory, and the quality of the video correlated with the source of the video. Videos from gastroenterologists provided more correct guidance with higher-quality information on the prevention and treatment of H. pylori infection.</p

Table_5_The status quo of short videos as a health information source of Helicobacter pylori: a cross-sectional study.XLSX

BackgroundHealth education about Helicobacter pylori (H. pylori) is one of the most effective methods to prevent H. pylori infection and standardize H. pylori eradication treatment. Short videos enable people to absorb and remember information more easily and are an important source of health education. This study aimed to assess the information quality of H. pylori-related videos on Chinese short video-sharing platforms.MethodsA total of 242 H. pylori-related videos from three Chinese short video-sharing platforms with the most users, TikTok, Bilibili, and Kwai, were retrieved. The Global Quality Score (GQS) and the modified DISCERN tool were used to assess the quality and content of videos, respectively. Additionally, comparative analyzes of videos based on different sources and common H. pylori issues were also conducted.ResultsThe median GQS score and DISCERN score was 2 for H. pylori-related videos analyzed in this study. Non-gastroenterologists posted the most H. pylori-related videos (136/242, 56.2%). Videos from gastroenterologists (51/242, 21.0%) had the highest GQS and DISCERN scores, with a median of 3. Few videos had content on family-based H. pylori infection control and management (5.8%), whether all H. pylori-positive patients need to undergo eradication treatment (27.7%), and the adverse effects of H. pylori eradication therapy (16.1%).ConclusionGenerally, the content and quality of the information in H. pylori-related videos were unsatisfactory, and the quality of the video correlated with the source of the video. Videos from gastroenterologists provided more correct guidance with higher-quality information on the prevention and treatment of H. pylori infection.</p

Table_3_The status quo of short videos as a health information source of Helicobacter pylori: a cross-sectional study.DOCX

BackgroundHealth education about Helicobacter pylori (H. pylori) is one of the most effective methods to prevent H. pylori infection and standardize H. pylori eradication treatment. Short videos enable people to absorb and remember information more easily and are an important source of health education. This study aimed to assess the information quality of H. pylori-related videos on Chinese short video-sharing platforms.MethodsA total of 242 H. pylori-related videos from three Chinese short video-sharing platforms with the most users, TikTok, Bilibili, and Kwai, were retrieved. The Global Quality Score (GQS) and the modified DISCERN tool were used to assess the quality and content of videos, respectively. Additionally, comparative analyzes of videos based on different sources and common H. pylori issues were also conducted.ResultsThe median GQS score and DISCERN score was 2 for H. pylori-related videos analyzed in this study. Non-gastroenterologists posted the most H. pylori-related videos (136/242, 56.2%). Videos from gastroenterologists (51/242, 21.0%) had the highest GQS and DISCERN scores, with a median of 3. Few videos had content on family-based H. pylori infection control and management (5.8%), whether all H. pylori-positive patients need to undergo eradication treatment (27.7%), and the adverse effects of H. pylori eradication therapy (16.1%).ConclusionGenerally, the content and quality of the information in H. pylori-related videos were unsatisfactory, and the quality of the video correlated with the source of the video. Videos from gastroenterologists provided more correct guidance with higher-quality information on the prevention and treatment of H. pylori infection.</p

Forest plot displaying the Risk Difference and 95% CIs of each study for the adequacy rate.

<p>Forest plot displaying the Risk Difference and 95% CIs of each study for the adequacy rate.</p

Operating characteristics in diagnosing pancreatic solid malignant lesions in the two groups (<i>n</i> = 163).

<p>CH-EUS, contrast-enhanced harmonic endoscopic ultrasonography; EUS, endoscopic ultrasonography group; AUC, area under receiver operating characteristic curve; PPV, positive predictive value; NPV, negative predictive value; 95% CI, 95% confidence interval.</p><p>*Suspicious cytology considered as diagnostic of malignancy.</p><p>#Atypical/suspicious cytology considered as a diagnostic of malignancy.</p><p>Operating characteristics in diagnosing pancreatic solid malignant lesions in the two groups (<i>n</i> = 163).</p