Semantic Information Extraction for Text Data with Probability Graph

In this paper, the problem of semantic information extraction for resource constrained text data transmission is studied. In the considered model, a sequence of text data need to be transmitted within a communication resource-constrained network, which only allows limited data transmission. Thus, at the transmitter, the original text data is extracted with natural language processing techniques. Then, the extracted semantic information is captured in a knowledge graph. An additional probability dimension is introduced in this graph to capture the importance of each information. This semantic information extraction problem is posed as an optimization framework whose goal is to extract most important semantic information for transmission. To find an optimal solution for this problem, a Floyd's algorithm based solution coupled with an efficient sorting mechanism is proposed. Numerical results testify the effectiveness of the proposed algorithm with regards to two novel performance metrics including semantic uncertainty and semantic similarity

Probabilistic Semantic Communication over Wireless Networks with Rate Splitting

In this paper, the problem of joint transmission and computation resource allocation for probabilistic semantic communication (PSC) system with rate splitting multiple access (RSMA) is investigated. In the considered model, the base station (BS) needs to transmit a large amount of data to multiple users with RSMA. Due to limited communication resources, the BS is required to utilize semantic communication techniques to compress the large-sized data. The semantic communication is enabled by shared probability graphs between the BS and the users. The probability graph can be used to further compress the transmission data at the BS, while the received compressed semantic information can be recovered through using the same shared probability graph at each user side. The semantic information compression progress consumes additional computation power at the BS, which inevitably decreases the transmission power due to limited total power budget. Considering both the effect of semantic compression ratio and computation power, the semantic rate expression for RSMA is first obtained. Then, based on the obtained rate expression, an optimization problem is formulated with the aim of maximizing the sum of semantic rates of all users under total power, semantic compression ratio, and rate allocation constraints. To tackle this problem, an iterative algorithm is proposed, where the rate allocation and transmit beamforming design subproblem is solved using a successive convex approximation method, and the semantic compression ratio subproblem is addressed using a greedy algorithm. Numerical results validate the effectiveness of the proposed scheme

Reconfigurable Intelligent Surface Based Orbital Angular Momentum: Architecture, Opportunities, and Challenges

Orbital angular momentum (OAM) has gained a lot of attention due to its potential in enhancing the spectral efficiency for wireless communications. Using different OAM modes, multiple independent data streams are simultaneously transmitted by using spatial distribution of helical phase, which enables OAM as a new form of multiple access technique for wireless communications. Controlling the phases of incoming electromagnetic waves, the reconfigurable intelligent surface (RIS) is suitable for implementing OAM. In this article, an RIS-based OAM framework is introduced. The basic concepts and features of RIS and OAM are presented. Then classifications and comparisons of different RIS-based OAM schemes are summarized. Simulation results verify that RIS-based OAM transmission can achieve nearly 100 percent higher spectral efficiency of wireless communication systems compared to the conventional RIS scheme

Outcome of Surgical Treatment in Late-Onset Capsular Block Syndrome

Purpose. To further investigate the pathogenesis of late-onset capsular block syndrome (CBS) and to evaluate the safety of surgical treatment. Methods. Seven patients diagnosed with late-onset CBS were retrospectively analyzed. Anterior chamber depth (ACD), intraocular pressure (IOP), refractive diopter, and best-corrected visual acuity (BCVA) before and after surgery were recorded. The opaque substance was tested with Western blot, and a flow cytometer multiple array assay system was utilized to evaluate the levels of inflammatory cytokines from opaque substance and aqueous humor, respectively. Results. Patients who had undergone surgical treatment showed a significant BCVA and spherical equivalent refractive error improvement (P=0.002, P=0.021, resp.). Nevertheless, ACD and IOP before and after surgery were in normal range with no difference (P=0.165, P=0.749, resp.). αB-crystallin and βB-crystallin were detected in all opaque substances. Tumor necrosis factor-alpha (TNF-α) and interlukin-1β (IL-1β) levels in opaque substance were significantly higher than those in aqueous humor (P=0.038, P=0.007, resp.), while IL-2 and IL-6 were not detected in any samples. Conclusions. Opaque substance is derived from human lens epithelial cells. Inflammatory cytokines may be involved in the pathogenesis of late-onset CBS. In addition, surgical treatment is an effective approach. This trial is registered with ChiCTR-IOR-17011287

Screening and validation of differentially expressed genes in adipose tissue of patients with obesity and type 2 diabetes mellitus

White adipose tissue (WAT) plays a pivotal role in the onset of type 2 diabetes mellitus (T2DM) and obesity. Despite its significance the underlying pathogenesis and key genes associated with it remain elusive. In our study, we screened the differentially expressed genes (DEGs) in intra-abdominal WAT of T2DM patients with obesity, as well as those with simple obesity, aiming to lay a foundational theory for an in-depth investigation of T2DM pathogenesis and the identification of novel therapeutic targets. Gene expression datasets (GSE16415 and GSE71416) were retrieved from the Gene Expression Omnibus (GEO) database. We employed R for screening DEGs and conducted a functional enrichment analysis using the Metascape database. Combined Lasso regression and Boruta feature selection algorithms were used to identify key DEGs. Subsequently, these were cross-verified using the GSE29231 dataset. Samples and medical records were collected from clinical study participants. The mRNA and protein expressions of the key DEGs were verified using qRT-PCR and western blotting, respectively. We discerned a total of 130 DEGs, with 40 being upregulated and 90 downregulated. Functional and pathway enrichment analyses illuminated that these genes are instrumental in mediating metabolite and energy production, neutrophil-mediated immunity, and other associated biological processes. This includes their involvement in the tricarboxylic acid cycle, glycolysis/gluconeogenesis, peroxisome proliferator-activated receptors, and other signalling pathways. Two genes, CIDEA and FSCN1 emerged as key DEGs. The low expression of CIDEA and high expression of FSCN1 in the T2DM and obesity group were verified in clinical samples (P < 0.05). We established that CIDEA and FSCN1 manifest significant differential expression in T2DM patients who are obese. This suggests their potential as risk assessment markers and therapeutic targets for T2DM

An experimental investigation of properties of Q345 steel pipe at elevated temperatures

This paper presents the results of an extensive experimental investigation of the thermal and mechanical properties of Q345 steel pipe at elevated temperatures using both the steady-state and transient-state test methods. Under these two test conditions, the thermal expansion coefficient, yield strength and elastic modulus of the specimens at different temperatures were measured. The tested results indicate that both the yield strength and elastic modulus decrease gradually with increasing temperature. However, at the same temperature, both the yield strength and elastic modulus tested using the steady-state test are higher than those tested using the transient-state test. Hence, it is less safe to use the material properties tested using the steady-state test for fire resistance design of the steel structure. Based on the transient-state test results, the models of the mechanical properties of Q345 steel pipe at elevated temperatures were proposed. These models can be used for the design and analysis of Q345 steel pipe structures under fire conditions.2012 Specialized Research Fund for the Doctoral Programme of Higher Education of China (Grant No. 20120095110027)

Luteolin inhibits GPVI-mediated platelet activation, oxidative stress, and thrombosis

Introduction: Luteolin inhibits platelet activation and thrombus formation, but the mechanisms are unclear. This study investigated the effects of luteolin on GPVI-mediated platelet activation in vitro and explored the effect of luteolin on thrombosis, coagulation, and platelet production in vivo.Methods: Washed human platelets were used for aggregation, membrane protein expression, ATP, Ca2+, and LDH release, platelet adhesion/spreading, and clot retraction experiments. Washed human platelets were used to detect collagen and convulxin-induced reactive oxygen species production and endogenous antioxidant effects. C57BL/6 male mice were used for ferric chloride-induced mesenteric thrombosis, collagen-epinephrine induced acute pulmonary embolism, tail bleeding, coagulation function, and luteolin toxicity experiments. The interaction between luteolin and GPVI was analyzed using solid phase binding assay and surface plasmon resonance (SPR).Results: Luteolin inhibited collagen- and convulxin-mediated platelet aggregation, adhesion, and release. Luteolin inhibited collagen- and convulxin-induced platelet ROS production and increased platelet endogenous antioxidant capacity. Luteolin reduced convulxin-induced activation of ITAM and MAPK signaling molecules. Molecular docking simulation showed that luteolin forms hydrogen bonds with GPVI. The solid phase binding assay showed that luteolin inhibited the interaction between collagen and GPVI. Surface plasmon resonance showed that luteolin bonded GPVI. Luteolin inhibited integrin αIIbβ3-mediated platelet activation. Luteolin inhibited mesenteric artery thrombosis and collagen- adrenergic-induced pulmonary thrombosis in mice. Luteolin decreased oxidative stress in vivo. Luteolin did not affect coagulation, hemostasis, or platelet production in mice.Discussion: Luteolin may be an effective and safe antiplatelet agent target for GPVI. A new mechanism (decreased oxidative stress) for the anti-platelet activity of luteolin has been identified