A VCM-based novel whole-spacecraft vibration isolation device: simulation and experiment

In the launching process, the spacecraft situated in an extreme dynamic environment may withstand by various dynamic loads such as noise loading in the fairing, motor excited vibration, shock of the separation devices, etc. To achieve a successful launching, the device called whole-spacecraft vibration isolator is usually installed between the adapter and the spacecraft to prevent the later from being damage. A novel WSVI device, which composed of supporting leaf springs, voice coil motors (VCM) and actuator supports, is designed to suppress the structural vibration of the spacecraft in this paper. The novel WSVI device features small space footprint and light weight, and satisfy the design requirement of vibration isolation without changing of the Payload Adaptor Fitting structure. A dynamic model of the WSVI device is established to evaluate the performance of the system. The dynamic characteristics and responses subjected to external excitation are studied for the spacecraft installed with WSVI. The vibration isolation performance is analyzed after turning the VCM into passive dampers. The results show that the novel WSVI device, which can reduce the amplitude of vibration response of the spacecraft significantly, is valid for vibration suppression of the spacecraft

A VCM-based novel whole-spacecraft vibration isolation device: simulation and experiment

In the launching process, the spacecraft situated in an extreme dynamic environment may withstand by various dynamic loads such as noise loading in the fairing, motor excited vibration, shock of the separation devices, etc. To achieve a successful launching, the device called whole-spacecraft vibration isolator is usually installed between the adapter and the spacecraft to prevent the later from being damage. A novel WSVI device, which composed of supporting leaf springs, voice coil motors (VCM) and actuator supports, is designed to suppress the structural vibration of the spacecraft in this paper. The novel WSVI device features small space footprint and light weight, and satisfy the design requirement of vibration isolation without changing of the Payload Adaptor Fitting structure. A dynamic model of the WSVI device is established to evaluate the performance of the system. The dynamic characteristics and responses subjected to external excitation are studied for the spacecraft installed with WSVI. The vibration isolation performance is analyzed after turning the VCM into passive dampers. The results show that the novel WSVI device, which can reduce the amplitude of vibration response of the spacecraft significantly, is valid for vibration suppression of the spacecraft

Anti-inflammatory and antioxidant activity of ursolic acid: a systematic review and meta-analysis

Introduction: There is currently evidence suggesting that ursolic acid may exert a favorable influence on both anti-inflammatory and antioxidant impact. Nevertheless, the anti-inflammatory and antioxidant activities of ursolic acid have not been systematically evaluated. Consequently, this study aims to conduct a systematic review and meta-analysis regarding the impact of ursolic acid on markers of inflammatory and antioxidant activity in both animal models and in vitro systems.Methods: The search encompassed databases such as PubMed, Web of Science, Google Scholar, and ScienceDirect, up until May 2023. All eligible articles in English were included in the analysis. Standard mean difference (SMD) was pooled using a random-effects model, and the included studies underwent a thorough assessment for potential bias.Results: The final review comprised 31 articles. In disease-model related studies, animal experiments have consistently shown that ursolic acid significantly reduced the levels of inflammatory parameters IL-1β, IL-6 and TNF-α in mouse tissues. In vitro studies have similarly showed that ursolic acid significantly reduced the levels of inflammatory parameters IL-1β, IL-6, IL-8 and TNF-α. Our results showed that ursolic acid could significantly elevate SOD and GSH levels, while significantly reducing MDA levels in animal tissues. The results of in vitro studies shown that ursolic acid significantly increased the level of GSH and decreased the level of MDA.Discussion: Findings from both animal and in vitro studies suggest that ursolic acid decreases inflammatory cytokine levels, elevates antioxidant enzyme levels, and reduces oxidative stress levels (graphical abstract). This meta-analysis furnishes compelling evidence for the anti-inflammatory and antioxidant properties of ursolic acid

Long-term antiplatelet therapy in medically managed non-ST-segment elevation acute coronary syndromes: The EPICOR Asia study

OBJECTIVES: To describe long-term antithrombotic management patterns (AMPs) in medically managed Asian patients with non-ST-segment myocardial infarction (NSTEMI) or unstable angina (UA). BACKGROUND: Current guidelines support an early invasive strategy in NSTEMI and UA patients, but many are medically managed, and data are limited on long-term AMPs in Asia. METHODS: Data were analyzed from medically managed NSTEMI and UA patients included in the prospective, observational EPICOR Asia study (NCT01361386). Survivors to hospital discharge were enrolled (June 2011 to May 2012) from 8 countries/regions across Asia. Baseline characteristics and AMP use up to 2 years post-discharge were collected. Outcomes were major adverse cardiovascular events (MACE: myocardial infarction, ischemic stroke, and death) and bleeding. RESULTS: Among 2289 medically managed patients, dual antiplatelet therapy (DAPT) use at discharge was greater in NSTEMI than in UA patients (81.8% vs 65.3%), and was significantly associated with male sex, positive cardiac markers, and prior cardiovascular medications (p < 0.0001). By 2 years, 57.9% and 42.6% of NSTEMI and UA patients, respectively, were on DAPT. On multivariable Cox regression analysis, risk of MACE at 2 years was most significantly associated with older age (HR [95% CI] 1.85 [1.36, 2.50]), diagnosis of NSTEMI vs UA (1.96 [1.47, 2.61]), and chronic renal failure (2.14 [1.34, 3.41]), all p ≤ 0.001. Risk of bleeding was most significantly associated with region (East Asia vs Southeast/South Asia) and diabetes. CONCLUSIONS: Approximately half of all patients were on DAPT at 2 years. MACE were more frequent in NSTEMI than UA patients during follow-up

Power Transfer Efficiency Analysis for Omnidirectional Wireless Power Transfer System Using Three-Phase-Shifted Drive

In order to implement the omnidirectional wireless power transfer (WPT), a novel three-phase-shifted drive omnidirectional WPT system is proposed. This system is comprised of three independent phase-adjusted excitation sources, three orthogonal transmitting coils, and one planar receiving coil. Based on the mutual coupling theory, the power transfer efficiency is derived and the corresponding control mechanism for maximizing this efficiency is presented. This control mechanism only depends on the currents&rsquo; root-mean-square (RMS) values of the three transmitting coils and simple calculations after each location and/or posture change of the receiving coil, which provides the real-time possibility to design an omnidirectional WPT system comparing with the other omnidirectional systems. In aid of computer emulation technique, the efficiency characteristic versus the omnidirectional location and posture of the receiving coil is analyzed, and the analytical results verify the validity of the control mechanism. Lastly, a hardware prototype has been set up, and its omnidirectional power transmission capacity has been successfully verified. The experimental results show that the wireless power is omnidirectional and it can be effectively transmitted to a load even though its receiving coil moves and/or rotates in a 3-D energy region

Dietary inflammatory potential is associated with higher odds of hepatic steatosis in US adults: a cross-sectional study

Abstract Objective: Inflammation plays a critical role in the progression of chronic liver diseases, and diet can modulate inflammation. Whether an inflammatory dietary pattern is associated with higher risk of hepatic steatosis or fibrosis remains unclear. We aimed to investigate the associations between inflammatory dietary pattern and the odds of hepatic steatosis and fibrosis. Design: In this nationwide cross-sectional study, diet was measured using two 24-h dietary recalls. Empirical dietary inflammatory pattern (EDIP) score was derived to assess the inflammatory potential of usual diet, which has been validated to highly predict inflammation markers in the study population. Controlled attenuation parameter (CAP) and liver stiffness measurement (LSM) were derived from FibroScan to define steatosis and fibrosis, respectively. Setting: US National Health and Nutrition Examination Survey. Participants: 4171 participants aged ≥18 years. Results: A total of 1436 participants were diagnosed with S1 steatosis (CAP ≥ 274 dB/m), 255 with advanced fibrosis (LSM ≥ 9·7 kPa). Compared with those in the lowest tertile of EDIP-adherence scores, participants in the highest tertile had 74 % higher odds of steatosis (OR: 1·74, 95 % CI (1·26, 2·41)). Such positive association persisted among never drinkers, or participants who were free of hepatitis B and/or C. Similarly, EDIP was positively associated with CAP in multivariate linear model (P < 0·001). We found a non-significant association of EDIP score with advanced fibrosis or LSM (P = 0·837). Conclusions: Our findings suggest that a diet score that is associated with inflammatory markers is associated with hepatic steatosis. Reducing or avoiding pro-inflammatory diets intake might be an attractive strategy for fatty liver disease prevention