Brain APOE expression quantitative trait loci-based association study identified one susceptibility locus for Alzheimer\u27s disease by interacting with APOE epsilon 4

AbstractSome studies have demonstrated interactions of AD-risk single nucleotide polymorphisms (SNPs) in non-APOE regions with APOE genotype. Nevertheless, no study reported interactions of expression quantitative trait locus (eQTL) for APOE with APOE genotype. In present study, we included 9286 unrelated AD patients and 8479 normal controls from 12 cohorts of NIA Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS) and Alzheimer’s Disease Neuroimaging Initiative (ADNI). 34 unrelated brain eQTLs for APOE were compiled from BRAINEAC and GTEx. We used multi-covariate logistic regression analysis to identify eQTLs interacted with APOE ε4. Adjusted for age and gender, substantia nigra eQTL rs438811 for APOE showed significantly strong interaction with APOE ε4 status (OR, 1.448; CI, 1.124–1.430; P-value = 7.94 × 10−6). APOE ε4-based sub-group analyses revealed that carrying one minor allele T of rs438811 can increase the opportunity of developing to AD by 26.75% in APOE ε4 carriers but not in non-carriers. We revealed substantia nigra eQTL rs438811 for APOE can interact with APOE ε4 and confers risk in APOE ε4 carriers only.</jats:p

Nuclear superfluidity for antimagnetic rotation in 105^{105}Cd and 106^{106}Cd

The effect of nuclear superfluidity on antimagnetic rotation bands in $^{105}$Cd and $^{106}$Cd are investigated by the cranked shell model with the pairing correlations and the blocking effects treated by a particle-number conserving method. The experimental moments of inertia and the reduced $B(E2)$ transition values are excellently reproduced. The nuclear superfluidity is essential to reproduce the experimental moments of inertia. The two-shears-like mechanism for the antimagnetic rotation is investigated by examining the shears angle, i.e., the closing of the two proton hole angular momenta, and its sensitive dependence on the nuclear superfluidity is revealed.Comment: 14 pages, 4 figure

Study on theory and operation of guided-exploring teaching mode

【摘要】导学探索式教学模式主旨是弘扬学生的主体学习精神，促使学生学会学习。导学探索式教学具有丰富的素质教育思想内涵，教学突出了学、思、导三个基本特征，教学活动体现了以教师为主导、以学生为主体、以培养学生创新精神和实践能力为主旨的“三为主”的教学思想。导学探索教学模式操作基本特点是先学后讲、先探索后讨论交流，教学活动程序大体分为导标、导学、讨论交流、教师精讲、巩固练习、评价小结等六步教学环节。Aiming at intensifying independent learning by the students and leading them to the right studying approach, the Guided-Exploring Teaching Mode emphasizes learning, thinking and guiding, which at the same time are basic features of Quality Education. Directed by the principle of teacher’s guidance, students orientation and improvement of learners’ creativity and practice, the teaching activities agree well with the methodology of inspiring teaching. The basic process of the Guided-Exploring Teaching Mode is studying prior to lecturing and exploration prior to discussion with six specific steps starting from lesson targets, lesson plan, pre-discussions, key points explaining, post-practice, to comments and summary

Systematic investigation of the rotational bands in nuclei with Z≈100Z \approx 100 using a particle-number conserving method based on a cranked shell model

The rotational bands in nuclei with $Z \approx 100$ are investigated systematically by using a cranked shell model (CSM) with the pairing correlations treated by a particle-number conserving (PNC) method, in which the blocking effects are taken into account exactly. By fitting the experimental single-particle spectra in these nuclei, a new set of Nilsson parameters ($\kappa$ and $\mu$) and deformation parameters ($\varepsilon_2$ and $\varepsilon_4$) are proposed. The experimental kinematic moments of inertia for the rotational bands in even-even, odd-$A$ and odd-odd nuclei, and the bandhead energies of the 1-quasiparticle bands in odd-$A$ nuclei, are reproduced quite well by the PNC-CSM calculations. By analyzing the $\omega$-dependence of the occupation probability of each cranked Nilsson orbital near the Fermi surface and the contributions of valence orbitals in each major shell to the angular momentum alignment, the upbending mechanism in this region is understood clearly.Comment: 21 pages, 24 figures, extended version of arXiv: 1101.3607 (Phys. Rev. C83, 011304R); added refs.; added Fig. 4 and discussions; Phys. Rev. C, in pres