Rheological properties and structural build-up of 3D printed magnesium potassium phosphate cement

This paper focuses on the rheological properties of 3D printed magnesium potassium phosphate cements (MKPCs) with different magnesium-to-phosphate (M/P) mass ratio, MgO fineness and supplementary cementitious materials (SCMs) types. The variable shear rate tests were used to monitor the extrudability. The highest slope of the evolution of storage modulus (G\u27) and the maximum static yield stress (Mτs) value were used as an indication of the rigidification rate. The increased M/P mass ratio, MgO fineness and SCMs addition resulted in the promoted structural build-up of 3D printed MKPCs. The consistency between the evolution of G\u27 and Mτs with elapsed time were observed and the comparable time values of tg and tMτs were obtained. XRD results indicate the reversible agglomeration at the very early minutes can be ascribed to the solely physical flocculation changes other than the new hydration product

Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B.

Sanfilippo syndrome type B (MPS IIIB) is characterized by profound mental retardation in childhood, dementia and death in late adolescence; it is caused by deficiency of α-N-acetylglucosaminidase and resulting lysosomal storage of heparan sulfate. A mouse model, generated by homologous recombination of the Naglu gene, was used to study pathological changes in the brain. We found earlier that neurons in the medial entorhinal cortex (MEC) and the dentate gyrus showed a number of secondary defects, including the presence of hyperphosphorylated tau (Ptau) detected with antibodies raised against Ptau in Alzheimer disease brain. By further use of immunohistochemistry, we now show staining in neurons of the same area for beta amyloid, extending the resemblance to Alzheimer disease. Ptau inclusions in the dentate gyrus of MPS IIIB mice were reduced in number when the mice were administered LiCl, a specific inhibitor of Gsk3β. Additional proteins found elevated in MEC include proteins involved in autophagy and the heparan sulfate proteoglycans, glypicans 1 and 5, the latter closely related to the primary defect. The level of secondary accumulations was associated with elevation of glypican, as seen by comparing brains of mice at different ages or with different mucopolysaccharide storage diseases. The MEC of an MPS IIIA mouse had the same intense immunostaining for glypican 1 and other markers as MPS IIIB, while MEC of MPS I and MPS II mice had weak staining, and MEC of an MPS VI mouse had no staining at all for the same proteins. A considerable amount of glypican was found in MEC of MPS IIIB mice outside of lysosomes. We propose that it is the extralysosomal glypican that would be harmful to neurons, because its heparan sulfate branches could potentiate the formation of Ptau and beta amyloid aggregates, which would be toxic as well as difficult to degrade

Characterization of four-qubit states via Bell inequalities

A set of Bell inequalities classifying the quantum entanglement of four-qubit states is presented. These inequalities involve only two measurement settings per observer and can characterize fully separable, bi-separable and tri-separable quantum states. In addition, a quadratic inequality of the Bell operators for four-qubit systems is derived

A quantum secret sharing scheme with verifiable function

In the $\left( {t,n} \right)$ threshold quantum secret sharing scheme, it is difficult to ensure that internal participants are honest. In this paper, a verifiable $\left( {t,n} \right)$ threshold quantum secret sharing scheme is designed combined with classical secret sharing scheme. First of all, the distributor uses the asymmetric binary polynomials to generate the shares and sends them to each participant. Secondly, the distributor sends the initial quantum state with the secret to the first participant, and each participant performs unitary operation that using the mutually unbiased bases on the obtained $d$ dimension single bit quantum state ($d$ is a large odd prime number). In this process, distributor can randomly check the participants, and find out the internal fraudsters by unitary inverse operation gradually upward. Then the secret is reconstructed after all other participants simultaneously public transmission. Security analysis show that this scheme can resist both external and internal attacks

Design and Synthesis of Novel Anticancer Peptide Nanoparticles

Cancer has now become a common disease affecting human health. Existing cancer treatment drugs can no longer meet the growing needs of cancer patients, and the emergence of anticancer drug resistance has exacerbated this phenomenon. By designing and synthesizing new anticancer peptide nanoparticles and studying their anticancer effects, new strategies for cancer treatment may be obtained. Novel anticancer peptides are synthesized by adding basic amino acids and solid-phase synthesis technology, and their structural information is determined by mass spectrometry. Nanoparticles of anticancer peptide were synthesized by nano-self-assembly technology. Two novel anticancer peptides exhibited anticancer activity, one of which was assembled into nanoparticles. The theoretical isoelectric points of the modified SZG3 and SZG5 are all greater than physiological pH, and will be positively charged under physiological conditions. The estimated half-life of SZG3 and SZG5 is significantly extended (30h), which is beneficial to increase the efficacy and reduce toxic and side effects. SZG3 and SZG5 have a good inhibitory effect on tumor cells and have low toxicity to normal cells. Keywords: anticancer peptide, study, design, cancer, nanoparticles&nbsp

Microstructure and Continuous Phase Transition of the Gauss-Bonnet AdS Black Hole

The phase transition of the Gauss-Bonnet AdS black hole has the similar property with the van der Waals thermodynamic system. However, it is determined by the Gauss-Bonnet coefficient {\alpha}, not only the horizon radius. Furthermore, the phase transition is not the pure one between a big black hole and a small black hole. With this issue, we introduce a new order parameter to investigate the critical phenomenonand to give the microstructure explanation of the Gauss-Bonnet AdS black hole phase transition. And the critical exponents are also obtained. At the critical pointof the Gauss-Bonnet AdS black hole, we reveal the microstructure of the black hole by investigating the thermodynamic geometry. These results perhaps provide some certain help to deeply explore the black hole microscopic structure and to build the quantum gravity.Comment: 19 pages, 11figure