The mechanism of the polarization dependence of the optical transmission in subwavelength metal hole arrays

We investigate the mechanism of extraordinary optical transmission in subwave-length metal hole arrays. Experimental results for the arrays consisting of square or rectangle holes are well explained about the dependence of transmission strength on the polarization direction of the incident light. This polarization dependence occurs in each single-hole. For a hole array, there is in addition an interplay between the adjacent holes which is caused by the transverse magnetic field of surface plasmon polariton on the metal film surfaces. Based on the detailed study of a single-hole and two-hole structures, a simple method to calculate the total tranmissivity of hole arrays is proposed.Comment: 34 pages, 7 figure

Mesenchymal stem cells-derived exosomal miR-653-5p suppresses laryngeal papilloma progression by inhibiting BZW2

Objectives: Although miR-653-5p has been validated to participate in the progression of multiple types of cancer, the functional role of exosomal miR-653-5p derived from Mesenchymal Stem Cells (MSCs) in Laryngeal Papilloma (LP) has still remained elusive. Hence, this study aimed to investigate the role of MSCs-derived exosomal miR-653-5p in LP. Methods: LP tissues (n = 15) and adjacent normal tissues (n = 10) were collected to examine the expression level of miR-653-5p. The expression level of miR-653-5p in LP cells and normal cells was also detected. Then, miR-653-5p was overexpressed or silenced to explore its effects on the proliferation, migration, invasion, and apoptosis of LP cells. Thereafter, the effects of exosomal miR-653-5p derived from MSCs on LP cell progression and the potential regulatory mechanism of miR-653-5p were assessed. Results: It was revealed that the expression level of miR-653-5p was downregulated in LP tissues and cells. In addition, miR-653-5p suppressed the proliferation, migration, invasion, and apoptosis of LP cells. Exosomes derived from MSCs played a suppressive role in LP development and mediated the transmission of miR-653-5p to LP cells. Further exploration identified Basic leucine Zipper and W2 domains 2 (BZW2) as the target of miR-653-5p. More importantly, the rescue experiments revealed that MSCs-secreted exosomal miR-653-5p efficiently inhibited the aggressive phenotypes of LP cells, which could be significantly reversed by BZW2 overexpression in LP cells. Conclusion: MSCs-derived exosomal miR-653-5p exerted inhibitory effects on LP progression through targeting BZW2, which provided a novel idea for the therapy of LP. Clinical Trial registration number: chictr-ior-17011021

Chaos signatures of current phase transition in a toroidal trap

In this work we demonstrate how the directed motion of atomic Bose-Einstein condensates in a toroidal trap can be controlled by applying a zero-mean oscillatory driving field. We show that due to the self-trapping effect in momentum space, the oscillatory amplitude of the current can be significantly suppressed and a nearly constant directed current can be obtained preserving the initial current values, by decreasing the driving amplitude, even when the atomic interactions are relatively small. We also reveal numerically the mean-field chaos can serve as an indicator of a quantum phase transition between the vanishing current regime and nonvanishing current regime. Our results are corroborated by an effective three-mode model, which provides an excellent account of the ratchet dynamics of the system.Comment: 7 pages, 9 figure

Gene and Pathway-Based Analysis: Second Wave of Genome-wide Association Studies

Despite great success of GWAS in identification of common genetic variants associated with complex diseases, the current GWAS have focused on single SNP analysis. However, single SNP analysis often identifies a number of the most significant SNPs that account for only a small proportion of the genetic variants and offers limited understanding of complex diseases. To overcome these limitations, we propose gene and pathway-based association analysis as a new paradigm for GWAS. As a proof of concept, we performed a comprehensive gene and pathway-based association analysis for thirteen published GWAS. Our results showed that the proposed new paradigm for GWAS not only identified the genes that include significant SNPs found by single SNP analysis, but also detected new genes in which each single SNP conferred small disease risk, but their joint actions were implicated in the development of diseases. The results also demonstrated that the new paradigm for GWAS was able to identify biologically meaningful pathways associated with the diseases which were confirmed by gene-set rich analysis using gene expression data

Analytical results for the superflow of spin-orbit-coupled Bose-Einstein condensates in optical lattices

In this paper, we show that for sufficiently strong atomic interactions, there exist analytical solutions of current-carrying nonlinear Bloch states at the Brillouin zone edge to the model of spin-orbit-coupled Bose-Einstein condensates (BECs) with symmetric spin interaction loaded into optical lattices. These simple but generic exact solutions provide an analytical demonstration of some intriguing properties which have neither an analog in the regular BEC lattice systems nor in the uniform spin-orbit-coupled BEC systems. It is an analytical example for understanding the superfluid and other related properties of the spin-orbit-coupled BEC lattice systems.Comment: 9 pages, 6 figure

Ferroelectric memristor based on Pt/BiFeO3/Nb-doped SrTiO3 heterostructure

We report a continuously tunable resistive switching behavior in Pt/BiFeO₃/Nb-doped SrTiO₃ heterostructure for ferroelectric memristor application. The resistance of this memristor can be tuned up to 5 × 10⁵% by applying voltage pulses at room temperature, which exhibits excellent retention and anti-fatigue characteristics. The observed memristive behavior is attributed to the modulation effect of the ferroelectric polarization reversal on the width of depletion region and the height of potential barrier of the p-n junction formed at the BiFeO₃/Nb-doped SrTiO₃ interface.This work was supported by the National Natural Science Foundation of China (Grant Nos. 11074193 and 51132001). Q.L. and Y.L. acknowledge the support of the Australian Research Council (ARC) in the form of ARC Discovery Grants