THE ESTABLISHMENT OF MATHEMATICAL MODEL OF THE TAKE-OFF SPEED OF AERIALS OF FREESTYLE SKIING

The take-off speed of freestyle skiing aerials is one of the key factors which can decide the success. However, the take-off speed depends on snow quality, circumstance condition, in-run slope angle, in-run distance, air resistance and skiers’ action. By using sports biomechanics, mathematical model and numerical simulation method and combining theory with experiment, this study sets up a mathematical model of outside circumstance and skiers’ self-adjustment, simulates the changes of inside and outside stress in each stage of sliding, calculates the parameters intuitively and then forms into speed values. The setup of this model can provide scientific guidance for ensuring necessary take-off speed for specific actions

Single nucleotide polymorphisms in thymic stromal lymphopoietin gene are not associated with allergic rhinitis susceptibility in Chinese subjects

BACKGROUND: Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine, implicated in the development and progression of allergic diseases. Recent studies have demonstrated significantly increased expression and synthesis of TSLPin nasal mucosa of patients with allergic rhinitis (AR), compared with nonallergic control subjects. Also, there is significant correlation between the level of TSLP mRNA and symptom severity in AR patients. In this study, we investigated whether polymorphisms in the TSLP gene were associated with increased risk of AR in the Chinese population. METHODS: In a candidate gene association study, we tested 11 single nucleotide polymorphisms (SNPs) in the TSLP gene in 368 AR and 325 control adult Han Chinese subjects from Beijing. The 11 SNPs were selected from the Chinese HapMap genotyping dataset to ensure complete genetic coverage. AR was established by questionnaire and clinical examination, and blood was drawn from all subjects for DNA extraction. The PLINK software package was used to perform statistical testing. RESULTS: In the single-locus analysis of AR risk, no significant differences in allele and genotype frequencies were found between AR and control subjects. Further logistic regression analyses adjusted for age and gender also failed to reveal significant associations between AR and the selected SNPs. Similarly, analysis stratified by gender, and haplotype or diplotype did not reveal any association with AR risk. CONCLUSION: Although TSLP presents itself as a good candidate for contributing to allergy, this study failed to find an association between specific SNPs in the TSLP gene and AR susceptibility in the Han Chinese population

PAWR (PRKC apoptosis WT1 regulator protein; Prostate apoptosis response-4, Par-4)

Review on PAWR, with data on DNA, on the protein encoded, and where the gene is implicated

Zeeman effect in centrosymmetric antiferromagnets controlled by an electric field

Centrosymmetric antiferromagnetic semiconductors, although abundant in nature, seem less promising than ferromagnets and ferroelectrics for practical applications in semiconductor spintronics. As a matter of fact, the lack of spontaneous polarization and magnetization hinders the efficient utilization of electronic spin in these materials. Here, we propose a paradigm to harness electronic spin in centrosymmetric antiferromagnets via Zeeman spin splittings of electronic energy levels -- termed as spin Zeeman effect -- which is controlled by electric field.By symmetry analysis, we identify twenty-one centrosymmetric antiferromagnetic point groups that accommodate such a spin Zeeman effect. We further predict by first-principles that two antiferromagnetic semiconductors, Fe$_2$TeO$_6$ and SrFe$_2$S$_2$O, are excellent candidates showcasing Zeeman splittings as large as $\sim$55 and $\sim$30 meV, respectively, induced by an electric field of 6 MV/cm. Moreover, the electronic spin magnetization associated to the splitting energy levels can be switched by reversing the electric field. Our work thus sheds light on the electric-field control of electronic spin in antiferromagnets, which broadens the scope of application of centrosymmetric antiferromagnetic semiconductors

Controllable Textual Inversion for Personalized Text-to-Image Generation

The recent large-scale generative modeling has attained unprecedented performance especially in producing high-fidelity images driven by text prompts. Text inversion (TI), alongside the text-to-image model backbones, is proposed as an effective technique in personalizing the generation when the prompts contain user-defined, unseen or long-tail concept tokens. Despite that, we find and show that the deployment of TI remains full of "dark-magics" -- to name a few, the harsh requirement of additional datasets, arduous human efforts in the loop and lack of robustness. In this work, we propose a much-enhanced version of TI, dubbed Controllable Textual Inversion (COTI), in resolving all the aforementioned problems and in turn delivering a robust, data-efficient and easy-to-use framework. The core to COTI is a theoretically-guided loss objective instantiated with a comprehensive and novel weighted scoring mechanism, encapsulated by an active-learning paradigm. The extensive results show that COTI significantly outperforms the prior TI-related approaches with a 26.05 decrease in the FID score and a 23.00% boost in the R-precision.Comment: 10 pages, 6 figures, 2 tables. Project Page: https://github.com/jnzju/COT

Engineering ferroelectricity in monoclinic hafnia

Ferroelectricity in the complementary metal-oxide semiconductor (CMOS)-compatible hafnia (HfO$_2$) is crucial for the fabrication of high-integration nonvolatile memory devices. However, the capture of ferroelectricity in HfO$_2$ requires the stabilization of thermodynamically-metastable orthorhombic or rhombohedral phases, which entails the introduction of defects (e.g., dopants and vacancies) and pays the price of crystal imperfections, causing unpleasant wake-up and fatigue effects. Here, we report a theoretical strategy on the realization of robust ferroelectricity in HfO$_2$-based ferroelectrics by designing a series of epitaxial (HfO$_2$)$_1$/(CeO$_2$)$_1$ superlattices. The advantages of the designated ferroelectric superlattices are defects free, and most importantly, on the base of the thermodynamically stable monoclinic phase of HfO$_2$. Consequently, this allows the creation of superior ferroelectric properties with an electric polarization $>$25 $\mu$C/cm$^2$ and an ultralow polarization-switching energy barrier at $\sim$2.5 meV/atom. Our work may open an entirely new route towards the fabrication of high-performance HfO$_2$ based ferroelectric devices

Temporal and spatial variations in body mass and thermogenic capacity associated with alterations in the gut microbiota and host transcriptome in mammalian herbivores

Acknowledgements This work was supported by the Second Tibetan Plateau Scientific Expedition and Research Program (No. 2019QZKK0501), the Joint Grant from Chinese Academy of Sciences–People's Government of Qinghai Province on Sanjiangyuan National Park (LHZX-2020-01), the prevention and control techniques and demonstration of rodent pest in degraded alpine degraded grassland of Plateau pasture (2023YFD1400101), and the project of western light for interdisciplinary teams.Peer reviewedPublisher PD

Redox-Modulated Phenomena and Radiation Therapy: The Central Role of Superoxide Dismutases

SIGNIFICANCE: Ionizing radiation is a vital component in the oncologist\u27s arsenal for the treatment of cancer. Approximately 50% of all cancer patients will receive some form of radiation therapy as part of their treatment regimen. DNA is considered the major cellular target of ionizing radiation and can be damaged directly by radiation or indirectly through reactive oxygen species (ROS) formed from the radiolysis of water, enzyme-mediated ROS production, and ROS resulting from altered aerobic metabolism. RECENT ADVANCES: ROS are produced as a byproduct of oxygen metabolism, and superoxide dismutases (SODs) are the chief scavengers. ROS contribute to the radioresponsiveness of normal and tumor tissues, and SODs modulate the radioresponsiveness of tissues, thus affecting the efficacy of radiotherapy. CRITICAL ISSUES: Despite its prevalent use, radiation therapy suffers from certain limitations that diminish its effectiveness, including tumor hypoxia and normal tissue damage. Oxygen is important for the stabilization of radiation-induced DNA damage, and tumor hypoxia dramatically decreases radiation efficacy. Therefore, auxiliary therapies are needed to increase the effectiveness of radiation therapy against tumor tissues while minimizing normal tissue injury. FUTURE DIRECTIONS: Because of the importance of ROS in the response of normal and cancer tissues to ionizing radiation, methods that differentially modulate the ROS scavenging ability of cells may prove to be an important method to increase the radiation response in cancer tissues and simultaneously mitigate the damaging effects of ionizing radiation on normal tissues. Altering the expression or activity of SODs may prove valuable in maximizing the overall effectiveness of ionizing radiation