Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation

Cardiovascular disease (CVD) causes an unparalleled proportion of the global burden of disease and will remain the main cause of mortality for the near future. Oxidative stress plays a major role in the pathophysiology of cardiac disorders. Several studies have highlighted the cardinal role played by the overproduction of reactive oxygen or nitrogen species in the pathogenesis of ischemic myocardial damage and consequent cardiac dysfunction. Isothiocyanates (ITC) are sulfur-containing compounds that are broadly distributed among cruciferous vegetables. Sulforaphane (SFN) is an ITC shown to possess anticancer activities by both in vivo and epidemiological studies. Recent data have indicated that the beneficial effects of SFN in CVD are due to its antioxidant and anti-inflammatory properties. SFN activates NF-E2-related factor 2 (Nrf2), a basic leucine zipper transcription factor that serves as a defense mechanism against oxidative stress and electrophilic toxicants by inducing more than a hundred cytoprotective proteins, including antioxidants and phase II detoxifying enzymes. This review will summarize the evidence from clinical studies and animal experiments relating to the potential mechanisms by which SFN modulates Nrf2 activation and protects against CVD

Cellular immunotherapy as maintenance therapy prolongs the survival of the patients with small cell lung cancer in extensive stage

AbstractBackgroundSmall cell lung cancer (SCLC) is the most devastating type of human lung cancer. Patients usually present with disseminated disease to many organs (extensive stage). This study was to investigate the efficacy and safety of cellular immunotherapy (CIT) with autologous natural killer (NK), γδT, and cytokine-induced killer (CIK) cells as maintenance therapy for extensive-stage SCLC (ES-SCLC) patients.MethodsA pilot prospective cohort study was conducted with ES-SCLC patients who had responded to initial chemotherapy. Patients received either CIT as maintenance therapy (CIT group), or no treatment (control group). Progression-free survival (PFS), overall survival (OS), and adverse effects were compared.ResultsForty-nine patients were recruited in this study, with 19 patients in the CIT group and 30 patients in the control group. The patient characteristics of the 2 groups were comparable except for age, as patients in the CIT group were older than those in the control group (P < 0.05). PFS in the CIT group was superior to the control group (5 vs. 3.1 months, P = 0.020; HR, 0.489, 95% CI, 0.264–0.909, P = 0.024). OS of the CIT group was also longer than that of the control group (13.3 vs. 8.2 months, P = 0.044; HR, 0.528, 95% CI, 0.280–0.996, P = 0.048, respectively). No significant adverse reactions occurred in patients undergoing CIT.ConclusionsCIT maintenance therapy in ES-SCLC prolonged survival with only minimal side effects. Integrating CIT into the current treatment may be a novel strategy for ES-SCLC patients, although further multi-center randomized trials are needed

Lapsed El Niño impact on Atlantic and Northwest Pacific tropical cyclone activity in 2023

The El Niño-Southern Oscillation (ENSO) is a major factor modulating interannual variability of tropical cyclone (TC) activity, typically resulting in the suppressed TC genesis frequency (TCGF) over the North Atlantic (NA) and a distinct northwest-southeast dipole pattern in TCGF anomaly over the western North Pacific (WNP) during El Niño years. However, the TC season of 2023, a year of strong El Niño, presented an intriguing departure from this norm, as the NA experienced an unexpectedly active season with 20 TCs, while the WNP witnessed a decrease in the basin count with only 13 TCs.</p

Demo for the 2023 tropical cyclone research

Tropical cyclones.</p

Gamma-delta (γδ) T cells: friend or foe in cancer development?

Abstract Background γδ T cells are a distinct subgroup of T cells containing T cell receptors (TCRs) γ and TCR δ chains with diverse structural and functional heterogeneity. As a bridge between the innate and adaptive immune systems, γδ T cells participate in various immune responses during cancer progression. Because of their direct/indirect antitumor cytotoxicity and strong cytokine production ability, the use of γδ T cells in cancer immunotherapy has received a lot of attention over the past decade. Main text Despite the promising potential of γδ T cells, the efficacy of γδ T cell immunotherapy is limited, with an average response ratio of only 21%. In addition, research over the past 2 years has shown that γδ T cells could also promote cancer progression by inhibiting antitumor responses, and enhancing cancer angiogenesis. As a result, γδ T cells have a dual effect and can therefore be considered as being both “friends” and “foes” of cancer. In order to solve the sub-optimal efficiency problem of γδ T cell immunotherapy, we review recent observations regarding the antitumor and protumor activities of major structural and functional subsets of human γδ T cells, describing how these subsets are activated and polarized, and how these events relate to subsequent effects in cancer immunity. A mixture of both antitumor or protumor γδ T cells used in adoptive immunotherapy, coupled with the fact that γδ T cells can be polarized from antitumor cells to protumor cells appear to be the likely reasons for the mild efficacy seen with γδ T cells. Conclusion The future holds the promise of depleting the specific protumor γδ T cell subgroup before therapy, choosing multi-immunocyte adoptive therapy, modifying the cytokine balance in the cancer microenvironment, and using a combination of γδ T cells adoptive immunotherapy with immune checkpoint inhibitors

Correction to: Gamma-delta (γδ) T cells: friend or foe in cancer development?

Following publication of the original article [1], the authors reported that they omitted to state that parts of Fig. 2 were adapted from Van Acker et al. [2] published by Taylor & Francis Ltd (www.tandfonline.com). The authors apologise for this omission. Figure 2 and its corrected caption are given below

Global warming hiatus contributed to the increased occurrence of intense tropical cyclones in the coastal regions along East Asia

Abstract The recent global warming hiatus (GWH) was characterized by a La Niña–like cooling in the tropical Eastern Pacific accompanied with the Indian Ocean and the tropical Atlantic Ocean warming. Here we show that the recent GWH contributed significantly to the increased occurrence of intense tropical cyclones in the coastal regions along East Asia since 1998. The GWH associated sea surface temperature anomalies triggered a pair of anomalous cyclonic and anticyclonic circulations and equatorial easterly anomalies over the Northwest Pacific, which favored TC genesis and intensification over the western Northwest Pacific but suppressed TC genesis and intensification over the southeastern Northwest Pacific due to increased vertical wind shear and anticyclonic circulation anomalies. Results from atmospheric general circulation model experiments demonstrate that the Pacific La Niña–like cooling dominated the Indian Ocean and the tropical Atlantic Ocean warming in contributing to the observed GWH-related anomalous atmospheric circulation over the Northwest Pacific

ENSO-driven abrupt phase shift in North Atlantic oscillation in early January

Abstract El Niño-Southern Oscillation (ENSO) teleconnections exhibit a strong dependency on seasonally and intraseasonally varying mean states, leading to impactful short-term variations in regional climate. The North Atlantic Oscillation (NAO)-ENSO relation is a typical example, in that its phase relationship reverses systematically between the early and late winter. Here based on observations and an ensemble of atmosphere-only climate model simulations, we reveal that this NAO phase reversal occurs synchronously in early January, showing strong abruptness. We demonstrate that this abrupt NAO phase reversal is caused by the change in ENSO-induced Rossby wave-propagating direction from northeastward to southeastward over the northeastern North American region, which is largely governed by a climatological alteration of the local jet meridional shear. We also provide evidence that the North Atlantic intrinsic eddy–low-frequency flow feedback further amplifies the NAO responses. This ENSO-related abrupt NAO change offers an avenue for intraseasonal climate forecasting in the Euro-Atlantic region