Chiral metallohelices enantioselectively target hybrid human telomeric G-quadruplex DNA

The design and synthesis of metal complexes that can specifically target DNA secondary structure has attracted considerable attention. Chiral metallosupramolecular complexes (e.g. helicates) in particular display unique DNA-binding behavior, however until recently few examples which are both water-compatible and enantiomerically pure have been reported. Herein we report that one metallohelix enantiomer , available from a diastereoselective synthesis with no need for resolution, can enantioselectively stabilize human telomeric hybrid G-quadruplex and strongly inhibit telomerase activity with IC 50 of 600 nM. In contrast, no such a preference is observed for the mirror image complex . More intriguingly, neither of the two enantiomers binds specifically to human telomeric antiparallel G-quadruplex. To the best of our knowledge, this is the first example of one pair of enantiomers with contrasting selectivity for human telomeric hybrid G-quadruplex. Further studies show that can discriminate human telomeric G-quadruplex from other telomeric G-quadruplexes

Mirror-image dependence : targeting enantiomeric G-quadruplex DNA using triplex metallohelices

Natural d‐DNA and l‐DNA are mirror‐image counterparts. However, because of the inherent flexibility and conformation diversity of DNA, it is still not clear how enantiomeric compounds recognize d‐DNA and l‐DNA. Herein, taking G‐quadruplex (G4) DNA as an example that has diverse conformations and distinct biofunctions, the binding of ten pairs of iron triplex metallohelices to d‐ and l‐G4 DNA were evaluated. The Δ‐enantiomer binds to d‐DNA and the Λ‐enantiomer binds to l‐DNA, exhibiting almost the same stabilization effect and binding affinity. The binding affinity of the Δ‐metallohelix with d‐G4 is nearly 70‐fold higher than that of Λ‐metallohelix binding d‐G4. Δ‐Metallohelix binding to d‐G4 follows a two‐step binding process driven by a favorable enthalpy contribution to compensate for the associated unfavorable entropy

Let Storytelling Tell Vivid Stories: An Expressive and Fluent Multimodal Storyteller

Storytelling aims to generate reasonable and vivid narratives based on an ordered image stream. The fidelity to the image story theme and the divergence of story plots attract readers to keep reading. Previous works iteratively improved the alignment of multiple modalities but ultimately resulted in the generation of simplistic storylines for image streams. In this work, we propose a new pipeline, termed LLaMS, to generate multimodal human-level stories that are embodied in expressiveness and consistency. Specifically, by fully exploiting the commonsense knowledge within the LLM, we first employ a sequence data auto-enhancement strategy to enhance factual content expression and leverage a textual reasoning architecture for expressive story generation and prediction. Secondly, we propose SQ-Adatpter module for story illustration generation which can maintain sequence consistency. Numerical results are conducted through human evaluation to verify the superiority of proposed LLaMS. Evaluations show that LLaMS achieves state-of-the-art storytelling performance and 86% correlation and 100% consistency win rate as compared with previous SOTA methods. Furthermore, ablation experiments are conducted to verify the effectiveness of proposed sequence data enhancement and SQ-Adapter

CharacterChat: Learning towards Conversational AI with Personalized Social Support

In our modern, fast-paced, and interconnected world, the importance of mental well-being has grown into a matter of great urgency. However, traditional methods such as Emotional Support Conversations (ESC) face challenges in effectively addressing a diverse range of individual personalities. In response, we introduce the Social Support Conversation (S2Conv) framework. It comprises a series of support agents and the interpersonal matching mechanism, linking individuals with persona-compatible virtual supporters. Utilizing persona decomposition based on the MBTI (Myers-Briggs Type Indicator), we have created the MBTI-1024 Bank, a group that of virtual characters with distinct profiles. Through improved role-playing prompts with behavior preset and dynamic memory, we facilitate the development of the MBTI-S2Conv dataset, which contains conversations between the characters in the MBTI-1024 Bank. Building upon these foundations, we present CharacterChat, a comprehensive S2Conv system, which includes a conversational model driven by personas and memories, along with an interpersonal matching plugin model that dispatches the optimal supporters from the MBTI-1024 Bank for individuals with specific personas. Empirical results indicate the remarkable efficacy of CharacterChat in providing personalized social support and highlight the substantial advantages derived from interpersonal matching. The source code is available in \url{https://github.com/morecry/CharacterChat}.Comment: 10 pages, 6 figures, 5 table

Thermal performance of cold thermal energy storage system with fin and fin–foam structures

The heat transfer performance of most cold thermal energy storage (CTES) devices is limited by the low thermal conductivity of phase change materials (PCMs) and the increase in the thickness of PCMs. A comparative work was performed to explore the heat transfer performance of CTES systems with a fin structure (Fin-CTES) and a fin–foam structure (Fin–foam-CTES). The heat transfer performance, temperature distribution, and thermal effectiveness of Fin-CTES and Fin–foam-CTES at different inlet temperatures and volume flow rates of heat transfer fluid were investigated and compared. Results demonstrated that the overall heat transfer performance of Fin–foam-CTES is better than that of Fin-CTES. However, compared with the PCM in Fin-CTES, that in Fin–foam-CTES has a greater degree of supercooling, reaching 4.35 °C at the maximum. In the discharging (melting) process, Fin-CTES and Fin–foam-CTES have almost similar heat transfer effectiveness, in which the maximum difference is only 0.0107. That is, the enhanced heat transfer effect of the natural convection of the liquid PCM and the metal foam is basically the same during the discharging process.</p

Lini0.5mn1.5o4 spinel cathode using room temperature ionic liquid as electrolyte

In this study, LiNi0.5Mn1.5O4 (LNMO) nanoparticles were prepared as a 5 V cathode material via a rheological phase method and annealed at different temperatures: 680 ◦C, 750 ◦C, and 820 ◦C. The sample annealed at 750 ◦C shows the best performance. A room temperature ionic liquid (RTIL) containing 1 M lithium bis(trifluoromethanesulfonyl) imide (LiNTf2) in N-butyl-N-methyl-pyrrolidinium bis(trifluoromethanesulfonyl) imide (C4mpyrNTf2) was used as novel electrolyte in conjunction with the LNMO cathodes and their electrochemical properties have been investigated. The results show that the LNMO using RTIL as electrolyte has better coulombic efficiency and comparable discharge capacities to those of the cells assembled with standard liquid electrolyte (1 M LiPF6 in ethylene carbonate/diethyl carbonate). Electrochemical impedance spectroscopy shows that the RTIL is much more stable as the electrolyte for LiNi0.5Mn1.5O4 than the conventional electrolyte

Effects of adding bile acids to dietary storage japonica brown rice on growth performance, meat quality, and intestinal microbiota of growing–finishing Min pigs

IntroductionThis study investigated the effects of storage japonica brown rice (SJBR) and bile acids (BA) on the growth performance, meat quality, and intestinal microbiota of growing–finishing Min pigs.MethodsA total of 24 healthy Min pigs with a similar body weight of 42.25 ± 2.13 kg were randomly divided into three groups with eight replicates of one pig each. The groups were as follows: CON (50% corn), SJBR (25% corn +25% SJBR), and SJBR + BA (25% corn +25% SJBR +0.025% hyodeoxycholic acid). The experimental period lasted from day 90 (the end of the nursery phase) to day 210 (the end of the finishing phase).ResultsThe results showed the following: (1) Compared with the CON group, there was no significant difference in the average daily gain (ADG) and average daily feed intake (ADFI) of the SJBR and SJBR + BA groups, and the feed conversion ratio (FCR) was significantly decreased (p &lt; 0.05). (2) Compared with the CON group, the total protein (TP) content in the serum was significantly increased, and the blood urea nitrogen (BUN) content was significantly decreased (p &lt; 0.05) in the SJBR and SJBR + BA groups; moreover, HDL-C was significantly higher by 35% (p &lt; 0.05) in the SJBR + BA group. (3) There were no significant differences in carcass weight, carcass length, pH, drip loss, cooking loss, and shear force among the groups; the eye muscle area was significantly increased in the SJBR group compared with the CON group (p &lt; 0.05); back fat thickness was significantly decreased in the SJBR + BA group compared with the SJBR group (p &lt; 0.05); and the addition of SJBR significantly increased the mRNA expression of MyHC I in the longissimus dorsi (LD) muscle of growing–finishing Min pigs (p &lt; 0.05). (4) The cecal bacteria were detected using 16S rDNA, and the proportion of Lactobacillus was increased gradually at the genus level, but there was no significant difference among the different groups.ConclusionIn conclusion, 25% SJBR can improve the growth performance and increase the abundance of intestinal beneficial bacteria, and based on this, adding bile acids can reduce the back fat thickness of growing–finishing Min pigs

Simultaneously achieving high energy density and responsivity in submicron BaTiO3 film capacitors integrated on Si

In the research field of energy storage dielectrics, the “responsivity” parameter, defined as the recyclable/recoverable energy density per unit electric field, has become critically important for a comprehensive evaluation of the energy storage capability of a dielectric. In this work, high recyclable energy density and responsivity, i.e., Wrec = 161.1 J·cm–3 and ξ = 373.8 J·(kV·m2)–1, have been simultaneously achieved in a prototype perovskite dielectric, BaTiO3, which is integrated on Si at 500 ℃ in the form of a submicron thick film. This ferroelectric film features a multi-scale polar structure consisting of ferroelectric grains with different orientations and inner-grain ferroelastic domains. A LaNiO3 buffer layer is used to induce a {001} textured, columnar nanograin microstructure, while an elevated deposition temperature promotes lateral growth of the nanograins (in-plane diameter increases from ~10–20 nm at lower temperatures to ~30 nm). These preferably oriented and periodically regulated nanograins have resulted in a small remnant polarization and a delayed polarization saturation in the film’s P–E behavior, leading to a high recyclable energy density. Meanwhile, an improved polarizability/dielectric constant of the BaTiO3 film has produced a much larger maximum polarization than those deposited at lower temperatures at the same electric field, leading to a record-breaking responsivity for this simple perovskite