1 research outputs found
Acetal-Linked Hyperbranched Polyphosphoester Nanocarriers Loaded with Chlorin e6 for pH-Activatable Photodynamic Therapy
Nanocarrier-mediated
photodynamic therapy (PDT), which involves the systemic delivery of
photosensitizers (PSs) into tumor tissue and tumor cells, has emerged
as an attractive treatment for cancer. However, insufficient PS release
limits intracellular cytotoxic reactive oxygen species (ROS) generation,
which has become a major obstacle to improving the PDT therapeutic
efficacy. Herein, a novel hyperbranched polyphosphoester (hbPPE) containing
numerous acetal bonds (S-hbPPE/Ce6) was explored as a chlorin e6 (Ce6)
nanocarrier for PDT. S-hbPPE/Ce6 with a branched topological structure
efficiently encapsulated Ce6 and then significantly enhanced its internalization
by tumor cells. Subsequently, the endo-/lysosomal acid microenvironment
rapidly cleaved the acetal linkage of S-hbPPE and destroyed the nanostructure
of S-hbPPE/Ce6, resulting in increased Ce6 release and obviously elevated
the intracellular ROS generation under illumination. Therefore, treatment
with S-hbPPE/Ce6 noticeably enhanced the PDT therapeutic efficacy,
indicating that such a pH-sensitive hbPPE nanocarrier has great potential
to improve the PDT therapeutic efficacy for cancer therapy