The Molecular Pathogenesis of Pituitary Adenomas: An Update

Pituitary tumors represent the most common intracranial neoplasms accompanying serious morbidity through mass effects and inappropriate secretion of pituitary hormones. Understanding the etiology of pituitary tumorigenesis will facilitate the development of satisfactory treatment for pituitary adenomas. Although the pathogenesis of pituitary adenomas is largely unknown, considerable evidence indicates that the pituitary tumorigenesis is a complex process involving multiple factors, including genetic and epigenetic changes. This review summarized the recent progress in the study of pituitary tumorigenesis, focusing on the role of tumor suppressor genes, oncogenes and microRNAs

Investigation of Stick Propellant Internal Perforation Erosive Burning on Interior Ballistics Performances

In this study, a thorough investigation of a stick propellant internal perforation erosive burning on interior ballistic performances is presented via extending the previous work of author. The stick propellant combustion process and the internal perforation erosive burning are revealed by numerical simulations. Different factors with respect to the stick propellant, including propellant length, internal perforation diameter and loading density are analysed in detail. Stick propellant length and the internal perforation diameter have a significant influence on the ballistic performance, the longer and smaller internal propellant have a greater erosive burning effect to the ballistic performance. Loading density has very weak influence on the ballistic