Realization of Analog Wavelet Filter using Hybrid Genetic Algorithm for On-line Epileptic Event Detection

© 2020 The Author(s). This open access work is licensed under a Creative Commons Attribution 4.0 License. For more information, see http://creativecommons.org/licenses/by/4.0/.As the evolution of traditional electroencephalogram (EEG) monitoring unit for epilepsy diagnosis, wearable ambulatory EEG (WAEEG) system transmits EEG data wirelessly, and can be made miniaturized, discrete and social acceptable. To prolong the battery lifetime, analog wavelet filter is used for epileptic event detection in WAEEG system to achieve on-line data reduction. For mapping continuous wavelet transform to analog filter implementation with low-power consumption and high approximation accuracy, this paper proposes a novel approximation method to construct the wavelet base in analog domain, in which the approximation process in frequency domain is considered as an optimization problem by building a mathematical model with only one term in the numerator. The hybrid genetic algorithm consisting of genetic algorithm and quasi-Newton method is employed to find the globally optimum solution, taking required stability into account. Experiment results show that the proposed method can give a stable analog wavelet base with simple structure and higher approximation accuracy compared with existing method, leading to a better spike detection accuracy. The fourth-order Marr wavelet filter is designed as an example using Gm-C filter structure based on LC ladder simulation, whose power consumption is only 33.4 pW at 2.1Hz. Simulation results show that the design method can be used to facilitate low power and small volume implementation of on-line epileptic event detector.Peer reviewe

Design of Gm-C wavelet filter for on-line epileptic EEG detection

Copyright © 2019 The Institute of Electronics, Information and Communication EngineersAnalog filter implementation of continuous wavelet transform is considered as a promising technique for on-line spike detection applied in wearable electroencephalogram system. This Letter proposes a novel method to construct analog wavelet base for analog wavelet filter design, in which the mathematical approximation model in frequency domain is built as an optimization problem and the genetic algorithm is used to find the global optimum resolution. Also, the Gm-C filter structure based on LC ladder simulation is employed to synthesize the obtained analog wavelet base. The Marr wavelet filter is designed as an example using SMIC 1V 0.35μm CMOS technology. Simulation results show that the proposed method can give a stable analog wavelet filter with higher approximation accuracy and excellent circuit performance, which is well suited for the design of low-frequency low-power spike detector.Peer reviewe

An Analysis on the Development Model of China’s County-level E-commerce

Based on the case studies of e-commerce activities in six counties of China’s eastern, middle and western regions respectively, this paper has probed into the characteristics of e-commerce development of each county, which are then classified into four development models of county-level e-commerce in China, featuring the integration and aggregation of resources endowment and production factors. The paper further analyzes the key factors contributing to the success of county-level e-commerce development, in a bid to provide reference and guidance for other counties in their e-commerce activities

Automatic Implementation of Neural Networks through Reaction Networks -- Part I: Circuit Design and Convergence Analysis

Information processing relying on biochemical interactions in the cellular environment is essential for biological organisms. The implementation of molecular computational systems holds significant interest and potential in the fields of synthetic biology and molecular computation. This two-part article aims to introduce a programmable biochemical reaction network (BCRN) system endowed with mass action kinetics that realizes the fully connected neural network (FCNN) and has the potential to act automatically in vivo. In part I, the feedforward propagation computation, the backpropagation component, and all bridging processes of FCNN are ingeniously designed as specific BCRN modules based on their dynamics. This approach addresses a design gap in the biochemical assignment module and judgment termination module and provides a novel precise and robust realization of bi-molecular reactions for the learning process. Through equilibrium approaching, we demonstrate that the designed BCRN system achieves FCNN functionality with exponential convergence to target computational results, thereby enhancing the theoretical support for such work. Finally, the performance of this construction is further evaluated on two typical logic classification problems

Surprising complexity of the ancestral apoptosis network

A comparative genomics approach revealed that the genes for several components of the apoptosis network with single copies in vertebrates have multiple paralogs in cnidarian-bilaterian ancestors, suggesting a complex evolutionary history for this network

Liver fatty acid composition in mice with or without nonalcoholic fatty liver disease

<p>Abstract</p> <p>Background</p> <p>Nonalcoholic fatty liver disease (NAFLD) is one of the most frequent causes of abnormal liver function. Because fatty acids can damage biological membranes, fatty acid accumulation in the liver may be partially responsible for the functional and morphological changes that are observed in nonalcoholic liver disease. The aim of this study was to use gas chromatography-mass spectrometry to evaluate the fatty acid composition of an experimental mouse model of NAFLD induced by high-fat feed and CCl₄and to assess the association between liver fatty acid accumulation and NAFLD. C57BL/6J mice were given high-fat feed for six consecutive weeks to develop experimental NAFLD. Meanwhile, these mice were given subcutaneous injections of a 40% CCl₄-vegetable oil mixture twice per week.</p> <p>Results</p> <p>A pathological examination found that NAFLD had developed in the C57BL/6J mice. High-fat feed and CCl₄led to significant increases in C14:0, C16:0, C18:0 and C20:3 (P < 0.01), and decreases in C15:0, C18:1, C18:2 and C18:3 (P < 0.01) in the mouse liver. The treatment also led to an increase in SFA and decreases in other fatty acids (UFA, PUFA and MUFA). An increase in the ratio of product/precursor n-6 (C20:4/C18:2) and n-3 ([C20:5+C22:6]/C18:3) and a decrease in the ratio of n-6/n-3 (C20:4/[C20:5+C22:6]) were also observed.</p> <p>Conclusion</p> <p>These data are consistent with the hypothesis that fatty acids are deranged in mice with non-alcoholic fatty liver injury induced by high-fat feed and CCl₄, which may be involved in its pathogenesis and/or progression via an unclear mechanism.</p