Aharonov-Bohm oscillations in the local density of topological surface states

We study Aharonov-Bohm (AB) oscillations in the local density of states (LDOS) for topological insulator (TI) and conventional metal Au(111) surfaces with spin-orbit interaction, which can be probed by spin-polarized scanning tunneling microscopy. We show that the spacial AB oscillatory period in the total LDOS is a flux quantum $\Phi_{0}\mathtt{=}hc/e$ (weak localization) in both systems. Remarkably, an analogous weak antilocalization with $\Phi_{0}/2$ periodic spacial AB oscillations in spin components of LDOS for TI surface is observed, while it is absent in Au(111).Comment: 4 APL pages, 3 figure

On design of robust fault detection filter in finite-frequency domain with regional pole assignment

This brief is concerned with the fault detection (FD) filter design problem for an uncertain linear discrete-time system in the finite-frequency domain with regional pole assignment. An optimized FD filter is designed such that: 1) the FD dynamics is quadratically D-stable; 2) the effect from the exogenous disturbance on the residual is attenuated with respect to a minimized H∞-norm; and 3) the sensitivity of the residual to the fault is enhanced by means of a maximized H--norm. With the aid of the generalized Kalman-Yakubovich-Popov lemma, the mixed H--/H∞ performance and the D-stability requirement are guaranteed by solving a convex optimization problem. An iterative algorithm for designing the desired FD filter is proposed by evaluating the threshold on the generated residual function. A simulation result is exploited to illustrate the effectiveness of the proposed design technique.This work was supported in part by the Deanship of Scientific Research (DSR) at King Abdulaziz University in Saudi Arabia under Grant 16-135- 35-HiCi, the National Natural Science Foundation of China under Grants 61134009 and 61203139, the Royal Society of the U.K., and the Alexander von Humboldt Foundation of Germany

Munc13-1 MUN domain and Munc18-1 cooperatively chaperone SNARE assembly through a tetrameric complex

Munc13-1 is a large multifunctional protein essential for synaptic vesicle fusion and neurotransmitter release. Its dysfunction has been linked to many neurological disorders. Evidence suggests that the MUN domain of Munc13-1 collaborates with Munc18-1 to initiate SNARE assembly, thereby priming vesicles for fast calcium-triggered vesicle fusion. The underlying molecular mechanism, however, is poorly understood. Recently, it was found that Munc18-1 catalyzes neuronal SNARE assembly through an obligate template complex intermediate containing Munc18-1 and 2 SNARE proteins—syntaxin 1 and VAMP2. Here, using single-molecule force spectroscopy, we discovered that the MUN domain of Munc13-1 stabilizes the template complex by ∼2.1 kBT. The MUN-bound template complex enhances SNAP-25 binding to the templated SNAREs and subsequent full SNARE assembly. Mutational studies suggest that the MUN-bound template complex is functionally important for SNARE assembly and neurotransmitter release. Taken together, our observations provide a potential molecular mechanism by which Munc13-1 and Munc18-1 cooperatively chaperone SNARE folding and assembly, thereby regulating synaptic vesicle fusion

Recovery of the orbital parameters and pulse evolution of V0332+53 during a huge outburst

The high mass X-ray binary (HMXB) V0332+53 became active at the end of 2004 and the outburst was observed at hard X-rays by RXTE and INTEGRAL. Based on these hard X-ray observations, the orbital parameters are measured through fitting the Doppler-shifted spin periods. The derived orbital period and eccentricity are consistent with those of Stella et al. (1985) obtained from EXOSAT observations, whereas the projected semimajor axis and the periastron longitude are found to have changed from 48$\pm$4 to 86$^{+6}_{-10}$ lt-s and from 313$^{\circ}$$\pm$10 to 283$^{\circ}$$\pm$14, respectively. This would indicate an angular speed of $\geq$ 1.5$^{\circ}$$\pm$0.8 yr$^{-1}$ for rotation of the orbit over the past 21 years. The periastron passage time of MJD 53367$\pm$1 is just around the time when the intensity reached maximum and an orbital period earlier is the time when the outburst started. This correlation resembles the behavior of a Type I outburst. During outburst the source spun up with a rate of 8.01$^{+1.00}_{-1.14}$$\times10^{-6}$ s day$^{-1}$. The evolution of pulse profile is highly intensity dependent. The separation of double pulses remained almost constant ($\sim$ 0.47) when the source was bright, and dropped to 0.37 within $\leq$ 3 days as the source became weaker. The pulse evolution of V0332+53 may correlate to the change in dominance of the emission between fan-beam and pencil-beam mechanisms.Comment: 13 pages, 3 figures, accepted for publication in ApJ

SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D To Facilitate Viral Replication.

Accumulating evidence suggests that viruses hijack cellular proteins to circumvent the host immune system. Ubiquitination and SUMOylation are extensively studied posttranslational modifications (PTMs) that play critical roles in diverse biological processes. Cross talk between ubiquitination and SUMOylation of both host and viral proteins has been reported to result in distinct functional consequences. Enterovirus 71 (EV71), an RNA virus belonging to the family Picornaviridae, is a common cause of hand, foot, and mouth disease. Little is known concerning how host PTM systems interact with enteroviruses. Here, we demonstrate that the 3D protein, an RNA-dependent RNA polymerase (RdRp) of EV71, is modified by small ubiquitin-like modifier 1 (SUMO-1) both during infection and in vitro Residues K159 and L150/D151/L152 were responsible for 3D SUMOylation as determined by bioinformatics prediction combined with site-directed mutagenesis. Also, primer-dependent polymerase assays indicated that mutation of SUMOylation sites impaired 3D polymerase activity and virus replication. Moreover, 3D is ubiquitinated in a SUMO-dependent manner, and SUMOylation is crucial for 3D stability, which may be due to the interplay between the two PTMs. Importantly, increasing the level of SUMO-1 in EV71-infected cells augmented the SUMOylation and ubiquitination levels of 3D, leading to enhanced replication of EV71. These results together suggested that SUMO and ubiquitin cooperatively regulated EV71 infection, either by SUMO-ubiquitin hybrid chains or by ubiquitin conjugating to the exposed lysine residue through SUMOylation. Our study provides new insight into how a virus utilizes cellular pathways to facilitate its replication. IMPORTANCE: Infection with enterovirus 71 (EV71) often causes neurological diseases in children, and EV71 is responsible for the majority of fatalities. Based on a better understanding of interplay between virus and host cell, antiviral drugs against enteroviruses may be developed. As a dynamic cellular process of posttranslational modification, SUMOylation regulates global cellular protein localization, interaction, stability, and enzymatic activity. However, little is known concerning how SUMOylation directly influences virus replication by targeting viral polymerase. Here, we found that EV71 polymerase 3D was SUMOylated during EV71 infection and in vitro Moreover, the SUMOylation sites were determined, and in vitro polymerase assays indicated that mutations at SUMOylation sites could impair polymerase synthesis. Importantly, 3D is ubiquitinated in a SUMOylation-dependent manner that enhances the stability of the viral polymerase. Our findings indicate that the two modifications likely cooperatively enhance virus replication. Our study may offer a new therapeutic strategy against virus replication

An ab initio quasi-diabatic potential energy matrix for OH(²Σ) + H₂

A diabatic potential energy matrix for three electronic states of OH₃ has been constructed by interpolation of multi-reference configuration interaction electronic structure data. The reactive, exchange and non-reactive quenching dynamics are investigated using surface hopping classical trajectories. Classical trajectory simulations show good agreement with cross molecular beam data for the OH(²Σ) + D₂ → HOD + D reaction

Density distributions for trapped one-dimensional spinor gases

We numerically evaluate the density distribution of a spin-1 bosonic condensate in its ground state within a modifed Gross-Pitaevskii theory, which is obtained by the combination of the exact solution of the corresponding integrable model with the local density approximation. Our study reveals that atoms in the m_F = 0 state are almost completely suppressed for the anti-ferromagnetic interactions in both weakly and strongly interacting regimes, whereas all three components remain non-vanishing for ferromagnetic interactions. Specially, when the system is in the Tonks-Girardeau (TG) regime, obvious Fermi-like distribution emerges for each component. We also discuss the possible deviation of the spatial distribution from the Fermi-like distribution when the spin-spin interaction is strong enough.Comment: 6 pages, 3 figures, version to be published in Phys. Rev.

Galaxy-galaxy weak-lensing measurement from SDSS: II. host halo properties of galaxy groups

As the second paper of a series on studying galaxy-galaxy lensing signals using the Sloan Digital Sky Survey Data Release 7 (SDSS DR7), we present our measurement and modelling of the lensing signals around groups of galaxies. We divide the groups into four halo mass bins, and measure the signals around four different halo-center tracers: brightest central galaxy (BCG), luminosity-weighted center, number-weighted center and X-ray peak position. For X-ray and SDSS DR7 cross identified groups, we further split the groups into low and high X-ray emission subsamples, both of which are assigned with two halo-center tracers, BCGs and X-ray peak positions. The galaxy-galaxy lensing signals show that BCGs, among the four candidates, are the best halo-center tracers. We model the lensing signals using a combination of four contributions: off-centered NFW host halo profile, sub-halo contribution, stellar contribution, and projected 2-halo term. We sample the posterior of 5 parameters i.e., halo mass, concentration, off-centering distance, sub halo mass, and fraction of subhalos via a MCMC package using the galaxy-galaxy lensing signals. After taking into account the sampling effects (e.g. Eddington bias), we found the best fit halo masses obtained from lensing signals are quite consistent with those obtained in the group catalog based on an abundance matching method, except in the lowest mass bin. Subject headings: (cosmology:) gravitational lensing, galaxies: clusters: generalComment: 12 pages, 7 figures, submitted to Ap