The Seismic Acquisition Method Researching for the Complex Mountainous Terrain in YXL Area Qaidam Basin

YXL area is the concentration area of exploration activity with classic complicate surface feature in Qaidam Basin. So, its interference wave is development and the seismic data is in low signal-to-noise ratio (SNR) in the area. Through multiple seismic exploration collecting means, Acquisition techniques has obtained great breakthrough, and array technique has showed great affection. The geological tasks and seismic exploration difficulties of target area is aimed in the paper. The remained problems in the past seismic exploration is dissected, studying the noise interference feature and the effects for the array noise attenuation. And the positive roles of the stack response for the noise attenuation is discussed and to supply the high quality and the high precision data for the seismic in this area.Key words: Shot-receiving array; Stack array response; Geometry; Direction effect; Array weighted average effect; Signal-to-noise rati

Distribution of unsteady pressure in volute type axial flow pump

In order to study the distribution of unsteady pressure in volute type axial flow pump, the k-ε turbulence model was applied, and ANSYS CFX was provided for numerical simulation calculation. Experiments of external characteristics and pressure fluctuation have been done to verify the results of numerical simulation. The results show that under the design operating condition, the main fluctuation frequencies in the volute, at the inlet and outlet of the impeller are the blade passing frequency. The amplitudes of fluctuation at the inlet of the impeller decrease gradually from the rim to the hub, while those at the export decrease firstly and then increase, the amplitudes at the tongue are much higher than that at other sections of the volute. Under the off-design operating conditions, the main fluctuation frequency at the inlet and outlet of the impeller is still the blade passing frequency, while that at the tongue is between the twice shaft frequency and the blade passing frequency, fluctuation amplitudes are both larger than those under the design operating condition. Under the design operating condition, the radial force on the impeller is the minimum, however, the axial force increases with the increase of flow rate. The distributions of unsteady pressure in volute type axial flow pump are different with general centrifugal or axial flow pump

HiPSC-derived cardiac tissue for disease modeling and drug discovery

Li, J.; Hua, Y.; Miyagawa, S.; Zhang, J.; Li, L.; Liu, L.; Sawa, Y. hiPSC-Derived Cardiac Tissue for Disease Modeling and Drug Discovery. Int. J. Mol. Sci. 2020, 21, 8893

Mapping the potential distribution of major tick species in China

Ticks are known as the vectors of various zoonotic diseases such as Lyme borreliosis and tick-borne encephalitis. Though their occurrences are increasingly reported in some parts of China, our understanding of the pattern and determinants of ticks’ potential distribution over the country remain limited. In this study, we took advantage of the recently compiled spatial dataset of distribution and diversity of ticks in China, analyzed the environmental determinants of ten frequently reported tick species and mapped the spatial distribution of these species over the country using the MaxEnt model. We found that presence of urban fabric, cropland, and forest in a place are key determents of tick occurrence, suggesting ticks were likely inhabited close to where people live. Besides, precipitation in the driest month was found to have a relatively high contribution in mapping tick distribution. The model projected that theses ticks could be widely distributed in the Northwest, Central North, Northeast, and South China. Our results added new evidence on the potential distribution of a variety of major tick species in China and pinpointed areas with a high potential risk of tick bites and tick-borne diseases for raising public health awareness and prevention response

Angiotensin II upregulates the expression of placental growth factor in human vascular endothelial cells and smooth muscle cells

<p>Abstract</p> <p>Background</p> <p>Atherosclerosis is now recognized as a chronic inflammatory disease. Angiotensin II (Ang II) is a critical factor in inflammatory responses, which promotes the pathogenesis of atherosclerosis. Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family cytokines and is associated with inflammatory progress of atherosclerosis. However, the potential link between PlGF and Ang II has not been investigated. In the current study, whether Ang II could regulate PlGF expression, and the effect of PlGF on cell proliferation, was investigated in human vascular endothelial cells (VECs) and smooth muscle cells (VSMCs).</p> <p>Results</p> <p>In growth-arrested human VECs and VSMCs, Ang II induced PlGF mRNA expression after 4 hour treatment, and peaked at 24 hours. 10^-6mol/L Ang II increased PlGF protein production after 8 hour treatment, and peaked at 24 hours. Stimulation with Ang II also induced mRNA expression of VEGF receptor-1 and -2(VEGFR-1 and -2) in these cells. The Ang II type I receptor (AT₁R) antagonist blocked Ang II-induced PlGF gene expression and protein production. Several intracellular signals elicited by Ang II were involved in PlGF synthesis, including activation of protein kinase C, extracellular signal-regulated kinase 1/2 (ERK1/2) and PI3-kinase. A neutralizing antibody against PlGF partially inhibited the Ang II-induced proliferation of VECs and VSMCs. However, this antibody showed little effect on the basal proliferation in these cells, whereas blocking antibody of VEGF could suppress both basal and Ang II-induced proliferation in VECs and VSMCs.</p> <p>Conclusion</p> <p>Our results showed for the first time that Ang II could induce the gene expression and protein production of PlGF in VECs and VSMCs, which might play an important role in the pathogenesis of vascular inflammation and atherosclerosis.</p

Observations of SN 2017ein Reveal Shock Breakout Emission and A Massive Progenitor Star for a Type Ic Supernova

We present optical and ultraviolet observations of nearby type Ic supernova SN 2017ein as well as detailed analysis of its progenitor properties from both the early-time observations and the prediscovery Hubble Space Telescope (HST) images. The optical light curves started from within one day to $\sim$275 days after explosion, and optical spectra range from $\sim$2 days to $\sim$90 days after explosion. Compared to other normal SNe Ic like SN 2007gr and SN 2013ge, \mbox{SN 2017ein} seems to have more prominent C{\footnotesize II} absorption and higher expansion velocities in early phases, suggestive of relatively lower ejecta mass. The earliest photometry obtained for \mbox{SN 2017ein} show indications of shock cooling. The best-fit obtained by including a shock cooling component gives an estimate of the envelope mass as $\sim$0.02 M$_{\odot}$ and stellar radius as 8$\pm$4 R$_{\odot}$. Examining the pre-explosion images taken with the HST WFPC2, we find that the SN position coincides with a luminous and blue point-like source, with an extinction-corrected absolute magnitude of M$_V$$\sim$$-$8.2 mag and M$_I$$\sim$$-$7.7 mag.Comparisons of the observations to the theoretical models indicate that the counterpart source was either a single WR star or a binary with whose members had high initial masses, or a young compact star cluster. To further distinguish between different scenarios requires revisiting the site of the progenitor with HST after the SN fades away.Comment: 28 pages, 19 figures; accepted for publication in The Astrophysical Journa

Direct and negative regulation of the sycO-ypkA-ypoJ operon by cyclic AMP receptor protein (CRP) in Yersinia pestis

<p>Abstract</p> <p>Background</p> <p>Pathogenic yersiniae, including <it>Y. pestis</it>, share a type III secretion system (T3SS) that is composed of a secretion machinery, a set of translocation proteins, a control system, and six Yop effector proteins including YpkA and YopJ. The cyclic AMP receptor protein (CRP), a global regulator, was recently found to regulate the laterally acquired genes (<it>pla </it>and <it>pst</it>) in <it>Y. pestis</it>. The regulation of T3SS components by CRP is unknown.</p> <p>Results</p> <p>The <it>sycO</it>, <it>ypkA </it>and <it>yopJ </it>genes constitute a single operon in <it>Y. pestis</it>. CRP specifically binds to the promoter-proximate region of <it>sycO</it>, and represses the expression of the <it>sycO-ypkA-yopJ </it>operon. A single CRP-dependent promoter is employed for the <it>sycO-ypkA-yopJ </it>operon, but two CRP binding sites (site 1 and site 2) are detected within the promoter region. A CRP box homologue is found in site 1 other than site 2. The determination of CRP-binding sites, transcription start site and core promoter element (-10 and -35 regions) promotes us to depict the structural organization of CRP-dependent promoter, giving a map of CRP-promoter DNA interaction for <it>sycO-ypkA-yopJ</it>.</p> <p>Conclusion</p> <p>The <it>sycO-ypkA-yopJ </it>operon is under the direct and negative regulation of CRP in <it>Y. pestis</it>. The <it>sycO-ypkA-yopJ </it>promoter-proximate regions are extremely conserved in <it>Y. pestis</it>, <it>Y. pseudotuberculosis </it>and <it>Y. enterocolitica</it>. Therefore, data presented here can be generally applied to the above three pathogenic yersiniae.</p