High-speed rail and tourism expansion in China: a spatial spillover effect perspective

Tourism exerts a great effect on the modern economy and relies largely on the flow of people facilitated by high-quality transportation infrastructure. Applying a spatial econometric method, this paper investigates the effect of high-speed rail (HSR) on tourism expansion in China from the view of the spatial spillover effect. Based on a 276 Chinese cities’ panel dataset over 2005–2019, a positive role of HSR in tourism expansion is observed. Compared with cities unconnected to the HSR network, cities accessible by HSR experienced a 22% increase in tourism revenue and a 38% rise in tourist arrivals. In addition, the connection of a city to the HSR network also exerts a great spatial spillover role in the increase of tourism revenue and arrivals in peripheral cities which are not directly connected by HSR. The research findings offer important insights on the relationship between transportation infrastructure and tourism with significant policy implications regarding tourism development. First published online 6 November 202

The Effects of Ambient Temperature on Lumbar Disc Herniation: A Retrospective Study

PurposeThis article was designed to provide critical evidence into the relationship between ambient temperature and intensity of back pain in people with lumbar disc herniation (LDH).MethodsData concerning patient's age, gender, diagnostic logout, admission time, discharge time, residence area, and work area (residence area and work area were used to ensure research area) from 2017 to 2019 were obtained from the Neck-Shoulder and Lumbocrural Pain Hospital in Jinan, China. A total of 1,450 hospitalization records were collected in total. The distributed lag non-linear model (DLNM) was used to evaluate the relationship between lag–response and exposure to ambient temperature. Stratification was based on age and gender. Days 1, 5, 20, and 28 prior to admission were denoted as lags 0, 5, 20, and 28, respectively.ResultsAn average daily temperature of 15–23°C reduced the risk of hospitalization the most in men. Conversely, temperatures <10°C drastically increased hospitalization in men, particularly in lags 0–5 and lags 20–28. Men aged between 40 and 50 years old showed less effect in pain sensation during ambient temperature.ConclusionHigh or low ambient temperature can increase the hospitalization risk of LDH, and sometimes, the temperature effect is delayed

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site

The sigma-2 receptor, whose gene remains to be cloned, has been validated as a biomarker for tumor cell proliferation. Here we report the use of a novel photoaffinity probe, WC-21, to identify the sigma-2 receptor binding site. WC-21, a sigma-2 ligand containing both a photoactive moiety azide and a fluorescein isothiocyanate group, irreversibly labels sigma-2 receptors in rat liver; the membrane-bound protein was then identified as PGRMC1 (progesterone receptor membrane component-1). Immunocytochemistry reveals that both PGRMC1 and SW120, a fluorescent sigma-2 receptor ligand, colocalizes with molecular markers of the endoplasmic reticulum and mitochondria in HeLa cells. Overexpression and knockdown of the PGRMC1 protein results in an increase and a decrease in binding of a sigma-2 selective radioligand, respectively. Th

The crystal structure of [1-(4-(trifluoromethyl)phenyl)-3,4-dihydroquinolin-2(1H)-one], C16H12F3NO

C16H12F3NO, orthorhombic, P212121 (no. 19), a = 6.9928(6) Å, b = 8.9764(8) Å, c = 21.216(2) Å, V = 1331.7(2) Å3, Z = 2, Rgt(F) = 0.0583, wRref(F2) = 0.1552, T = 298 K