Small Nuclear RNAs Encoded by Herpesvirus saimiri Upregulate the Expression of Genes Linked to T Cell Activation in Virally Transformed T Cells

SummarySeven small nuclear RNAs of the Sm class are encoded by Herpesvirus saimiri (HVS), a γ Herpesvirus that causes aggressive T cell leukemias and lymphomas in New World primates and efficiently transforms T cells in vitro [1–4]. The Herpesvirus saimiri U RNAs (HSURs) are the most abundant viral transcripts in HVS-transformed, latently infected T cells but are not required for viral replication or transformation in vitro [5]. We have compared marmoset T cells transformed with wild-type or a mutant HVS lacking the most highly conserved HSURs, HSURs 1 and 2. Microarray and Northern analyses reveal that HSUR 1 and 2 expression correlates with significant increases in a small number of host mRNAs, including the T cell-receptor β and γ chains, the T cell and natural killer (NK) cell-surface receptors CD52 and DAP10, and intracellular proteins—SKAP55, granulysin, and NKG7—linked to T cell and NK cell activation. Upregulation of three of these transcripts was rescued after transduction of deletion-mutant-HVS-transformed cells with a lentiviral vector carrying HSURs 1 and 2. These changes indicate an unexpected role for the HSURs in regulating a remarkably defined and physiologically relevant set of host targets involved in the activation of virally transformed T cells during latency

Corrigendum to "A modelling study to evaluate the costs and effects of lowering the starting age of population breast cancer screening" [Maturitas 109 (2018) 81-88].

The authors regret that the name Alicja M. Daszczuck, has been misspelled and should be Alicja M. Daszczuk. The authors would like to apologise for any inconvenience caused

Corrigendum to “A modelling study to evaluate the costs and effects of lowering the starting age of population breast cancer screening” [Maturitas 109 (2018) 81–88] (S0378512217305431) (10.1016/j.maturitas.2017.12.009))

The authors regret that the name Alicja M. Daszczuck, has been misspelled and should be Alicja M. Daszczuk. The authors would like to apologise for any inconvenience caused