Research on the Application of Value Creation of Big Data in Smart Tourism

Against the background of the new era, the rapid progress of information science and technology represented by big data, cloud computing and Internet of things promotes the intelligent transformation of tourism industry. Based on the technical support of big data, it integrates tourism resources to generate value creation and apply it in smart tourism, and promotes the optimization and innovation of tourism at the level of marketing, service and management. In the context of informatization, the implementation of smart tourism has become the only way for the development of the tourism industry (Dai, P. ,2015). However, the application of big data in smart tourism also faces such problems as dense and miscellaneous information data, uneven level of information technology, lack of smart tourism big data professionals, and privacy data security (Yang, X.,2015). This paper discusses the development status and future direction of smart tourism in the context of big data, so as to boost the steady development of smart tourism relying on big data platform

Design of GPS Information Processing System Based on Single Chip Microcomputer

With the rapid development of science and technology in the 21st century, the Global Positioning System (GPS) has become one of the representatives of the development achievements of this era. The system not only has high precision and good performance, but also has a wide range of application. It has been widely used in land, ocean, space and other fields, with a very high market share. In response to a surge in demand for satellite-positioning and navigation applications, In this paper, the GPS information processing system is constructed with hardware modules such as GPS receiving module and LCD module as the main structure, single chip microcomputer as the core controller, supplemented by necessary peripheral circuits. The success of GPS information processing system based on single chip microcomputer solves the problem of high price of GPS devices in the market. In general, the design structure is not only modular and easy to carry, the most important is the human nature, cost-effective, and has great practical value

Research and Industrial Application of a Process for Direct Reduction of Molten High-Lead Smelting Slag

© 2016, The Minerals, Metals & Materials Society. A pyrometallurgical process for the direct reduction of molten high-lead smelting slag obtained by the Shuikoushan (SKS) method was reported in this article using solid anthracite as the fuel and reductant. The chemical composition, the lead phase composition, and the physical properties of the molten high-lead slag were examined. The effects of the process parameters on the recovery rate of valued metals were investigated in the laboratory. According to the experimental results, a new efficient bottom blow reduction furnace was employed in the pilot-scale test for high-lead slag reduction. The results showed the average recovery rate of lead was more than 96.0% with lower Pb and high Zn content of the reducing slag under the condition of reduction temperature 1100–1200°C, coal ratio 5.5–7.5%, reduction time 90–150 min, CaO/SiO2 ratio 0.35–0.45, and FeO/SiO2 ratio 1.4–1.55. Moreover, nearly 250 kg of standard coal per ton of crude Pb output was reduced compared with the blast furnace reduction process

Preparation of smart glass with superhydrophobic and thermochromic properties

The practical application of VO2 smart glass is usually restricted by poor thermochromic property and contaminant. In this study, the VOx/SiO2 composite films were fabricated using magnetron sputtering and sol-gel preparations. Compared with VOx-based films, the VOx/SiO2 composite films showed the superhydrophobic property, and its water contact angle was up to 165 degrees. At the same time, the VOx/SiO2 composite films retained the original excellent thermochromic property with solar regulation of 13.95%, luminous transmittance of 37.34% and the low phase transition temperature around 38 degrees C. This study provided guidance for the combined application of VO2 smart glass and superhydrophobic coating

Histological and Pathological Assessment of miR-204 and SOX4 Levels in Gastric Cancer Patients

Gastric cancer is one of the most common cancers and the efficient therapeutic methods are limited. Further study of the exact molecular mechanism of gastric cancer to develop novel targeted therapies is necessary and urgent. We herein systematically examined that miR-204 suppressed both proliferation and metastasis of gastric cancer AGS cells. miR-204 directly targeted SOX4. In clinical tissue research, we determined that miR-204 was expressed much lower and SOX4 expressed much higher in gastric cancer tissues compared with normal gastric tissues. Associated analysis with clinicopathological parameters in gastric cancer patients showed miR-204 was associated with no lymph node metastasis and early tumor stages whereas SOX4 was associated with lymph node metastasis and advanced tumor stages. In addition, miR-204 and SOX4 were negatively correlated in tissues from gastric cancer patients. Our findings examined the important role of miR-204 and SOX4 played in gastric cancer, and they could be used as candidate therapeutic targets for gastric cancer therapy

Long non-coding RNA DANCR promotes malignant phenotypes of bladder cancer cells by modulating the miR-149/MSI2 axis as a ceRNA

Abstract Background Accumulating evidences have indicated that long non-coding RNAs (lncRNAs) are potential biomarkers that play key roles in tumor development and progression. Differentiation antagonizing non-protein noding RNA (DANCR) is a novel lncRNA that acts as a potential biomarker and is involved in the development of cancers. However, the clinical significance and molecular mechanism of DANCR in bladder cancer is still unknown. Methods The relative expression level of DANCR was determined by Real-Time qPCR in a total of 106 patients with urothelial bladder cancer and in different bladder cancer cell lines. Loss-of-function experiments were performed to investigate the biological roles of DANCR on bladder cancer cell proliferation, migration, invasion and tumorigenicity. Comprehensive transcriptional analysis, RNA-FISH, dual-luciferase reporter assay and western blot were performed to explore the molecular mechanisms underlying the functions of DANCR. Results In this study, we found that DANCR was significantly up-regulated in bladder cancer. Moreover, increased DANCR expression was positively correlated with higher histological grade and advanced TNM stage. Further experiments demonstrated that knockdown of DANCR inhibited malignant phenotypes and epithelial-mesenchymal transition (EMT) of bladder cancer cells. Mechanistically, we found that DANCR was distributed mostly in the cytoplasm and DANCR functioned as a miRNA sponge to positively regulate the expression of musashi RNA binding protein 2 (MSI2) through sponging miR-149 and subsequently promoted malignant phenotypes of bladder cancer cells, thus playing an oncogenic role in bladder cancer pathogenesis. Conclusion This study is the first to demonstrate that DANCR plays a critical regulatory role in bladder cancer cell and DANCR may serve as a potential diagnostic biomarker and therapeutic target of bladder cancer

Novel smart textile with phase change materials encapsulated core-sheath structure fabricated by coaxial electrospinning

The development of rational material structure design for thermo-regulated smart textiles based on phase change materials (PCMs) paraffin wax (PW) is paramount for effectively solving leakage issue in the process of phase change. Here, a material structure with high-performance in overcoming leakage of PW is achieved by coaxial electrospinning technique resulting from core-sheath structured smart textiles with PW as core layer and polyacrylonitrile (PAN) as sheath layer. Additionally, to improve the heat utilization efficiency of solar energy, the hexagonal cesium tungsten bronze (Cs0.32WO3) with excellent near-infrared region (NIR) absorbing ability is incorporated in the textiles. It is noteworthy that the smart textile possesses the high encapsulation efficiency of 54.3% (latent heat of 60.31 J/g) and shows good stability because of almost no change of latent heat for the smart textiles after 500 heating-cooling cycles. Hence, this work provides a meaningful guidance for smart textiles and opens up some opportunities for comfortable wearing

Green nano-encapsulation technique for preparation of phase change nanofibers mats with core-sheath structure

Inspired by the phase change materials (PCMs) based microcapsules, green phase change nanofibers mats with cores-heath structure based on paraffin wax emulsion (PWE) and polyvinyl alcohol (PVA) for thermal energy storage (TES) is obtained by coaxial electrospinning approach. The PWE could be encapsulated by PVA, simultaneously addressing the leakage issue effectively. In addition, the melting enthalpy (Delta H-m) increased from 3.16 J/g to 48.35 J/g as the core speed rate (R-core) increased from 0.1 to 2.0 it/min, indicating higher R-core can induce higher PWE encapsulation efficiency. Finally, the core-sheath structure PWE@PVA nanofibers mats have high Delta H-m of 48.25 J/g and freezing enthalpy (Delta H-c) of -47.75 J/g. Furthermore, only slightly decreasing tendency on the enthalpy can be observed after 500 heating-cooling cycles, demonstrating good TES stability and practicability of the as-prepared PWE@PVA nanofibers mats. Hence, this study offers new idea for the fabrication method of green PCMs

An On-Chip Microscale Vacuum Chamber with High Sealing Performance Using Graphene as Lateral Feedthrough

On-chip microscale vacuum chambers with high sealing performance and electrical feedthroughs are highly desired for microscale vacuum electronic devices and other MEMS devices. In this paper, we report an on-chip microscale vacuum chamber which achieves a high sealing performance by using monolayer graphene as lateral electrical feedthrough. A vacuum chamber with the dimensions of π × 2 mm × 2 mm × 0.5 mm is fabricated by anodically bonding a glass chip with a through-hole between two Si chips in a vacuum, after monolayer graphene electrodes have been transferred to the surface of one of the Si chips. Benefiting from the atomic thickness of monolayer graphene, the leak rate of Si–glass bonding interface with a monolayer graphene feedthrough is measured at less than 2 × 10−11 Pa·m3/s. The monolayer graphene feedthrough exhibits a minor resistance increase from 22.5 Ω to 31 Ω after anodic bonding, showing good electrical conductance. The pressure of the vacuum chamber is estimated to be 185 Pa by measuring the breakdown voltage. Such a vacuum is found to maintain for more than 50 days without obvious degradation, implying a high sealing performance with a leak rate of less than 1.02 × 10−16 Pa·m3/s

Using microRNAs as Novel Predictors of Urologic Cancer Survival: An Integrated AnalysisResearch in Context

Background: MicroRNAs(miRNAs) are involved in the formation, maintenance, and metastasis of urologic cancer. Here, we aim to gather and evaluate all of the evidence regarding the potential role of miRNAs as novel predictors of urologic cancer survival. Methods: A systematic review was performed to identify and score all of the published studies that evaluated the prognostic effects of miRNAs in kidney (KCa), bladder (BCa) or prostate cancer (PCa). Where appropriate, the summary effects of miRNAs on urologic cancer were meta-analysed. The reliability of those results was then further validated by an integrated analysis of the TCGA cohort and miRNA panel. Results: Of 151 datasets, 80 miRNAs were enrolled in this systematic review. A meta-analysis of the prognostic qualities of each miRNA identified an objective association between miRNA and prognosis. miR-21 was identified as an unfavourable miRNA with the overall survival (HR:2.699, 1.76–4.14, P < 0.001) across various prognostic events. Our further meta-analyses, integrating a parallel TCGA analysis, confirmed these partial previous results and further revealed different summary effects, such as the moderate effect of miR-21 in BCa. The refined miRNA panel (KCa-6: miR-27b, −942, −497, −144, −141 and -27a) was more capable of predicting the overall survival than was any single miRNAs included in it (HR: 3.214, 1.971–5.240, P < 0.01). Conclusions: A miRNA panel may be able to determine the prognosis of urologic tumour more effectively and compensate for the unreliability of individual miRNA in estimating prognosis. More large-scale studies are therefore required to evaluate the unbiased prognostic value of miRNAs in urologic cancer effectively. Keywords: miRNAs, Urologic cancer, Prognosis, Biomarker, Bioinformatics analysis, miRNA pane