The looping probability of random heteropolymers helps to understand the scaling properties of biopolymers

Random heteropolymers are a minimal description of biopolymers and can provide a theoretical framework to the investigate the formation of loops in biophysical experiments. A two--state model provides a consistent and robust way to study the scaling properties of loop formation in polymers of the size of typical biological systems. Combining it with self--adjusting simulated--tempering simulations, we can calculate numerically the looping properties of several realizations of the random interactions within the chain. Differently from homopolymers, random heteropolymers display at different temperatures a continuous set of scaling exponents. The necessity of using self--averaging quantities makes finite--size effects dominant at low temperatures even for long polymers, shadowing the length--independent character of looping probability expected in analogy with homopolymeric globules. This could provide a simple explanation for the small scaling exponents found in experiments, for example in chromosome folding

Orthogonal learning particle swarm optimization

Particle swarm optimization (PSO) relies on its learning strategy to guide its search direction. Traditionally, each particle utilizes its historical best experience and its neighborhood’s best experience through linear summation. Such a learning strategy is easy to use, but is inefficient when searching in complex problem spaces. Hence, designing learning strategies that can utilize previous search information (experience) more efficiently has become one of the most salient and active PSO research topics. In this paper, we proposes an orthogonal learning (OL) strategy for PSO to discover more useful information that lies in the above two experiences via orthogonal experimental design. We name this PSO as orthogonal learning particle swarm optimization (OLPSO). The OL strategy can guide particles to fly in better directions by constructing a much promising and efficient exemplar. The OL strategy can be applied to PSO with any topological structure. In this paper, it is applied to both global and local versions of PSO, yielding the OLPSO-G and OLPSOL algorithms, respectively. This new learning strategy and the new algorithms are tested on a set of 16 benchmark functions, and are compared with other PSO algorithms and some state of the art evolutionary algorithms. The experimental results illustrate the effectiveness and efficiency of the proposed learning strategy and algorithms. The comparisons show that OLPSO significantly improves the performance of PSO, offering faster global convergence, higher solution quality, and stronger robustness

Compressed Air Energy Storage-Part I: An Accurate Bi-linear Cavern Model

Compressed air energy storage (CAES) is suitable for large-scale energy storage and can help to increase the penetration of wind power in power systems. A CAES plant consists of compressors, expanders, caverns, and a motor/generator set. Currently used cavern models for CAES are either accurate but highly non-linear or linear but inaccurate. Highly non-linear cavern models cannot be directly utilized in power system optimization problems. In this regard, an accurate bi-linear cavern model for CAES is proposed in this first paper of a two-part series. The charging and discharging processes in a cavern are divided into several virtual states and then the first law of thermodynamics and ideal gas law are used to derive a cavern model, i.e., model for the variation of temperature and pressure in these processes. Thereafter, the heat transfer between the air in the cavern and the cavern wall is considered and integrated into the cavern model. By subsequently eliminating several negligible terms, the cavern model reduces to a bi-linear (linear) model for CAES with multiple (single) time steps. The accuracy of the proposed cavern model is verified via comparison with an accurate non-linear model.Comment: 8 page

Theta frequency prefrontal–hippocampal driving relationship during free exploration in mice

AbstractInter-connected brain areas coordinate to process information and synchronized neural activities engage in learning and memory processes. Recent electrophysiological studies in rodents have implicated hippocampal–prefrontal connectivity in anxiety, spatial learning and memory-related tasks. In human patients with schizophrenia and autism, robust reduced connectivity between the hippocampus (HPC) and prefrontal cortex (PFC) has been reported. However little is known about the directionality of these oscillations and their roles during active behaviors remain unclear. Here the directional information processing in mice was measured by Granger causality, a mathematical tool that has been used in neuroscience to quantify the oscillatory driving relationship between the ventral HPC (vHPC) and the PFC in two anxiety tests and between the dorsal HPC (dHPC) and the PFC in social interaction test. In the open field test, stronger vHPC driving to the PFC was found in the center compartment than in the wall area. In the light–dark box test, PFC to vHPC causality was higher than vHPC to PFC causality although no difference was found between the light and dark areas for the causality in both directions. In the social interaction test using Cx3cr1 knockout mice which model for deficient microglia-dependent synaptic pruning, higher PFC driving to the dHPC was found than driving from the dHPC to the PFC in both knockout mice and wild-type mice. Cx3cr1 knockout mice showed reduced baseline PFC driving to the dHPC compared to their wild-type littermates. PFC to dHPC causality could predict the actual time spent interacting with the social stimuli. The current findings indicate that directed oscillatory activities between the PFC and the HPC have task-dependent roles during exploration in the anxiety test and in the social interaction test

Compressed Air Energy Storage-Part II: Application to Power System Unit Commitment

Unit commitment (UC) is one of the most important power system operation problems. To integrate higher penetration of wind power into power systems, more compressed air energy storage (CAES) plants are being built. Existing cavern models for the CAES used in power system optimization problems are not accurate, which may lead to infeasible solutions, e.g., the air pressure in the cavern is outside its operating range. In this regard, an accurate CAES model is proposed for the UC problem based on the accurate bi-linear cavern model proposed in the first paper of this two-part series. The minimum switch time between the charging and discharging processes of CAES is considered. The whole model, i.e., the UC model with an accurate CAES model, is a large-scale mixed integer bi-linear programming problem. To reduce the complexity of the whole model, three strategies are proposed to reduce the number of bi-linear terms without sacrificing accuracy. McCormick relaxation and piecewise linearization are then used to linearize the whole model. To decrease the solution time, a method to obtain an initial solution of the linearized model is proposed. A modified RTS-79 system is used to verify the effectiveness of the whole model and the solution methodology.Comment: 8 page

Optimal Attack against Cyber-Physical Control Systems with Reactive Attack Mitigation

This paper studies the performance and resilience of a cyber-physical control system (CPCS) with attack detection and reactive attack mitigation. It addresses the problem of deriving an optimal sequence of false data injection attacks that maximizes the state estimation error of the system. The results provide basic understanding about the limit of the attack impact. The design of the optimal attack is based on a Markov decision process (MDP) formulation, which is solved efficiently using the value iteration method. Using the proposed framework, we quantify the effect of false positives and mis-detections on the system performance, which can help the joint design of the attack detection and mitigation. To demonstrate the use of the proposed framework in a real-world CPCS, we consider the voltage control system of power grids, and run extensive simulations using PowerWorld, a high-fidelity power system simulator, to validate our analysis. The results show that by carefully designing the attack sequence using our proposed approach, the attacker can cause a large deviation of the bus voltages from the desired setpoint. Further, the results verify the optimality of the derived attack sequence and show that, to cause maximum impact, the attacker must carefully craft his attack to strike a balance between the attack magnitude and stealthiness, due to the simultaneous presence of attack detection and mitigation

Modeling and Detecting False Data Injection Attacks against Railway Traction Power Systems

Modern urban railways extensively use computerized sensing and control technologies to achieve safe, reliable, and well-timed operations. However, the use of these technologies may provide a convenient leverage to cyber-attackers who have bypassed the air gaps and aim at causing safety incidents and service disruptions. In this paper, we study false data injection (FDI) attacks against railways' traction power systems (TPSes). Specifically, we analyze two types of FDI attacks on the train-borne voltage, current, and position sensor measurements - which we call efficiency attack and safety attack -- that (i) maximize the system's total power consumption and (ii) mislead trains' local voltages to exceed given safety-critical thresholds, respectively. To counteract, we develop a global attack detection (GAD) system that serializes a bad data detector and a novel secondary attack detector designed based on unique TPS characteristics. With intact position data of trains, our detection system can effectively detect the FDI attacks on trains' voltage and current measurements even if the attacker has full and accurate knowledge of the TPS, attack detection, and real-time system state. In particular, the GAD system features an adaptive mechanism that ensures low false positive and negative rates in detecting the attacks under noisy system measurements. Extensive simulations driven by realistic running profiles of trains verify that a TPS setup is vulnerable to the FDI attacks, but these attacks can be detected effectively by the proposed GAD while ensuring a low false positive rate.Comment: IEEE/IFIP DSN-2016 and ACM Trans. on Cyber-Physical System

Rotor field orientation speed and torque control of BDFM with adaptive second order sliding mode

This paper presents two cascaded second order sliding mode controllers (SOSMCs) for brushless doubly fed motor (BDFM) adjustable speed system, which regulate the speed and torque. And an adaptive super twisting algorithm is incorporated into the SOSMCs to adaptively regulate the law of SOSMC. The proposed controllers for BDFM eliminate the average chattering encountered by most sliding mode control (SMC) schemes, and also possess the robustness and excellent static and dynamic performances of SMC. Simulation results show that the proposed control strategy is feasible, proper and effective. © 2013 IEEE