Revisited and innovative perspectives of oral ulcer: from biological specificity to local treatment

Mouth ulcers, a highly prevalent ailment affecting the oral mucosa, leading to pain and discomfort, significantly impacting the patient’s daily life. The development of innovative approaches for oral ulcer treatment is of great importance. Moreover, a deeper and more comprehensive understanding of mouth ulcers will facilitate the development of innovative therapeutic strategies. The oral environment possesses distinct traits as it serves as the gateway to the digestive and respiratory systems. The permeability of various epithelial layers can influence drug absorption. Moreover, oral mucosal injuries exhibit distinct healing patterns compared to cutaneous lesions, influenced by various inherent and extrinsic factors. Furthermore, the moist and dynamic oral environment, influenced by saliva and daily physiological functions like chewing and speaking, presents additional challenges in local therapy. Also, suitable mucosal adhesion materials are crucial to alleviate pain and promote healing process. To this end, the review comprehensively examines the anatomical and structural aspects of the oral cavity, elucidates the healing mechanisms of oral ulcers, explores the factors contributing to scar-free healing in the oral mucosa, and investigates the application of mucosal adhesive materials as drug delivery systems. This endeavor seeks to offer novel insights and perspectives for the treatment of oral ulcers

Population genomics of an icefish reveals mechanisms of glacier-driven adaptive radiation in Antarctic notothenioids

Background Antarctica harbors the bulk of the species diversity of the dominant teleost fish suborder—Notothenioidei. However, the forces that shape their evolution are still under debate. Results We sequenced the genome of an icefish, Chionodraco hamatus, and used population genomics and demographic modelling of sequenced genomes of 52 C. hamatus individuals collected mainly from two East Antarctic regions to investigate the factors driving speciation. Results revealed four icefish populations with clear reproduction separation were established 15 to 50 kya (kilo years ago) during the last glacial maxima (LGM). Selection sweeps in genes involving immune responses, cardiovascular development, and photoperception occurred differentially among the populations and were correlated with population-specific microbial communities and acquisition of distinct morphological features in the icefish taxa. Population and species-specific antifreeze glycoprotein gene expansion and glacial cycle-paced duplication/degeneration of the zona pellucida protein gene families indicated fluctuating thermal environments and periodic influence of glacial cycles on notothenioid divergence. Conclusions We revealed a series of genomic evidence indicating differential adaptation of C. hamatus populations and notothenioid species divergence in the extreme and unique marine environment. We conclude that geographic separation and adaptation to heterogeneous pathogen, oxygen, and light conditions of local habitats, periodically shaped by the glacial cycles, were the key drivers propelling species diversity in Antarctica.info:eu-repo/semantics/publishedVersio

Measurement of Interfacial Characteristics of Horizontal and Inclined Oil–Water Flows by Using Wire-Mesh Sensor

Oil–water flows are widely encountered in petroleum, chemical, nuclear reactors, and other crucial industrial processes. Due to gravity and interaction between phases, horizontal and inclined oil–water two-phase flows are characterized by remarkable multi-scale structure characteristics, such as large-scale stratified interface and small-scale droplets entrainment. Moreover, a slight change in the pipe inclination will lead to significant changes in the local oil–water flow structures, which results in great challenges in the measurement of the interface structures. In this study, we design a 10 × 10 conductance wire-mesh sensor (WMS) to detect the interfacial characteristics of horizontal and inclined oil–water flows. Firstly, we carry out horizontal and inclined oil–water flow experiments. The influence of pipe inclinations on the flow transition boundary is analyzed. The three-dimensional (3D) structures of oil–water flows are visualized based on the WMS measurement response. Then, edge detection is implemented to process the two-dimensional (2D) flow images visualized by the WMS. The influence of complexly distributed droplets is effectively removed by using binary image morphological transformation and watershed algorithm, and thus, oil–water interface structures are accurately extracted. Finally, the influence of the oil–water flow conditions and pipe inclinations on the configuration, height, and length of the stratified interface are investigated

Research on the Enhancement of Laser Radar Range Image Recognition Using a Super-Resolution Algorithm

This work introduces a super-resolution (SR) algorithm for range images on the basis of self-guided joint filtering (SGJF), adding the range information of the range image as a coefficient of the filter to reduce the influence of the intensity image texture on the super-resolved image. A range image SR recognition system is constructed to study the effect of four SR algorithms including the SGJF algorithm on the recognition of the laser radar (ladar) range image. The effects of different model library sizes, SR algorithms, SR factors and noise conditions on the recognition are tested via experiments. Results demonstrate that all tested SR algorithms can improve the recognition rate of low-resolution (low-res) range images to varying degrees and the proposed SGJF algorithm has a very good comprehensive recognition performance. Finally, suggestions for the use of SR algorithms in actual scene recognition are proposed on the basis of the experimental results

Bluethunder: A 2-level Directional Predictor Based Side-Channel Attack against SGX

Software Guard Extension (SGX) is a hardware-based trusted execution environment (TEE) implemented in recent Intel commodity processors. By isolating the memory of security-critical applications from untrusted software, this mechanism provides users with a strongly shielded environment called enclave for executing programs safely. However, recent studies have demonstrated that SGX enclaves are vulnerable to side-channel attacks. In order to deal with these attacks, several protection techniques have been studied and utilized.In this paper, we explore a new pattern history table (PHT) based side-channel attack against SGX named Bluethunder, which can bypass existing protection techniques and reveal the secret information inside an enclave. Comparing to existing PHT-based attacks (such as Branchscope [ERAG+18]), Bluethunder abuses the 2-level directional predictor in the branch prediction unit, on top of which we develop an exploitation methodology to disclose the input-dependent control flow in an enclave. Since the cost of training the 2-level predictor is pretty low, Bluethunder can achieve a high bandwidth during the attack. We evaluate our attacks on two case studies: extracting the format string information in the vfprintf function in the Intel SGX SDK and attacking the implementation of RSA decryption algorithm in mbed TLS. Both attacks show that Bluethunder can recover fine-grained information inside an enclave with low training overhead, which outperforms the latest PHT-based side channel attack (Branchscope) by 52×. Specifically, in the second attack, Bluethunder can recover the RSA private key with 96.76% accuracy in a single run

The Stabilizing of 1T-MoS₂ for All-Solid-State Lithium-Ion Batteries

All-solid-state batteries (SSBs) are prospective candidates for a range of energy accumulation systems, delivering higher energy densities compared to batteries which use liquid electrolytes. Amongst the numerous solid-state electrolytes (SEs), sulfide-based electrolytes in particular have received more attention given that they have a high ionic conductivity. However, the incompatibility between the electrode and SEs is still an ongoing challenge that leads to poor electrochemical performance. In this work, we focus on 1T-MoS2. It is well known that 1T metallic MoS2 is unstable even at room temperature. However, we showed that 1T-MoS2 can be stabilized at 600 °C for at least 2 h, and the 1T-MoS2-600 interlayer spacing expanded to 0.95 nm. The high crystallinity of the 1T phase is highly compatible with solid electrolytes and coupled with the increased interlayer spacing, so in the all-solid-state lithium-ion battery (ALLLIB), we achieved outstanding cycling performance. At the current density of 0.2 C (1 C = 670 mA g−1), this material delivered a capacity of 406 mA h g−1 after 50 cycles

Oral Proactive Healthcare and Obesity

Oral health is closely related to systemic health. Common chronic oral diseases, periodontitis and periapical inflammation for example, not only affect the health of oral soft and hard tissues including the alveolar bone and gums, but may also cause changes in systemic conditions such as chronic low-grade inflammation, elevated oxidative stress levels, and dysbiosis of the microbiota. These changes in systemic health can exacerbate the progression of obesity. Therefore, through proactive oral health interventions such as maintaining good oral hygiene habits, modifying dietary structures, and undergoing oral examinations, it is possible to effectively prevent and alleviate inflammatory oral diseases, and actively intervene in obesity. This article delves into the impact of inflammatory oral diseases on obesity and their underlying mechanisms, defines the concept of 'oral proactive healthcare', and systematically summarizes their preventive and therapeutic effects on inflammatory oral diseases, thereby demonstrating the potential of improving obesity through proactive oral health strategies

Microporous and stable covalent organic framework for effective gas uptake

Covalent organic frameworks (COFs) are a new class of crystalline porous materials, maintaining porosity, stability, uniform pore channel, and well-designed skeletons. These features trait to be well suited as a platform for effective adsorption and separation of sorbents. Here, we reported microporous and stable COF with high-density N and O atoms that are implanted via the linker and vertex design. The new COF possessed high crystallinity, permanent micropores, excellent thermal and chemical stability, and high-density N and O atoms on the walls. Interestingly, the new COF is able to capture CO2 of 14.2 wt%, and iodine vapor of 456 wt%. These results evolve structural designs of COFs as effective gas uptake scaffolds