1,335 research outputs found
Microbial decomposition processes and vulnerable arctic soil organic carbon in the 21st century
Various levels of representations of biogeochemical processes in current
biogeochemistry models contribute to a large uncertainty in carbon budget
quantification. Here, we present an uncertainty analysis with a process-based
biogeochemistry model, the Terrestrial Ecosystem Model (TEM), into which detailed microbial mechanisms were incorporated. Ensemble regional simulations with
the new model (MIC-TEM) estimated that the carbon budget of the arctic
ecosystems is 76.0±114.8 Pg C during the 20th century, i.e., −3.1±61.7 Pg C under the RCP 2.6 scenario and 94.7±46 Pg C under the RCP
8.5 scenario during the 21st century. Positive values indicate the regional
carbon sink while negative values are a source to the atmosphere. Compared to
the estimates using a simpler soil decomposition algorithm in TEM, the new
model estimated that the arctic terrestrial ecosystems stored 12 Pg less
carbon over the 20th century, i.e., 19 and 30 Pg C less under the RCP 8.5
and RCP 2.6 scenarios, respectively, during the 21st century. When soil
carbon within depths of 30, 100, and 300 cm was considered as initial carbon
in the 21st century simulations, the region was estimated to accumulate 65.4,
88.6, and 109.8 Pg C, respectively, under the RCP 8.5 scenario. In
contrast, under the RCP 2.6 scenario, the region lost 0.7, 2.2, and 3 Pg C,
respectively, to the atmosphere. We conclude that the future regional carbon
budget evaluation largely depends on whether or not adequate microbial
activities are represented in earth system models and on the sizes of soil
carbon considered in model simulations.</p
KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation.
KDM2B (also known as FBXL10) controls stem cell self-renewal, somatic cell reprogramming and senescence, and tumorigenesis. KDM2B contains multiple functional domains, including a JmjC domain that catalyzes H3K36 demethylation and a CxxC zinc-finger that recognizes CpG islands and recruits the polycomb repressive complex 1. Here, we report that KDM2B, via its F-box domain, functions as a subunit of the CUL1-RING ubiquitin ligase (CRL1/SCF(KDM2B)) complex. KDM2B targets c-Fos for polyubiquitylation and regulates c-Fos protein levels. Unlike the phosphorylation of other SCF (SKP1-CUL1-F-box)/CRL1 substrates that promotes substrates binding to F-box, epidermal growth factor (EGF)-induced c-Fos S374 phosphorylation dissociates c-Fos from KDM2B and stabilizes c-Fos protein. Non-phosphorylatable and phosphomimetic mutations at S374 result in c-Fos protein which cannot be induced by EGF or accumulates constitutively and lead to decreased or increased cell proliferation, respectively. Multiple tumor-derived KDM2B mutations impaired the function of KDM2B to target c-Fos degradation and to suppress cell proliferation. These results reveal a novel function of KDM2B in the negative regulation of cell proliferation by assembling an E3 ligase to targeting c-Fos protein degradation that is antagonized by mitogenic stimulations
Superconducting Order Parameter in Bi-Layer Cuprates: Occurrence of Phase Shifts in Corner Junctions
We study the order parameter symmetry in bi-layer cuprates such as YBaCuO,
where interesting phase shifts have been observed in Josephson junctions.
Taking models which represent the measured spin fluctuation spectra of this
cuprate, as well as more general models of Coulomb correlation effects, we
classify the allowed symmetries and determine their associated physical
properties. phase shifts are shown to be a general consequence of
repulsive interactions, independent of whether a magnetic mechanism is
operative. While it is known to occur in d-states, this behavior can also be
associated with (orthorhombic) s-symmetry when the two sub-band gaps have
opposite phase. Implications for the magnitude of are discussed.Comment: 5 pages, RevTeX 3.0, 9 figures (available upon request
Comparison of spin dynamics in YBa2Cu3O7-δ and La2-xSrxCuO4: Effects of Fermi-surface geometry
Neutron experiments have indicated that the structure factor S(q,ω) for the two cuprates YBa2Cu3O7-δ and La2-xSrxCuO4 has a different q dependence. Commensurate peaks at (π/a,π/a) are observed in the former case, whereas clearly incommensurate peaks are seen in the latter, for metallic hole concentrations. We attribute this contrasting q dependence to differences in the Fermi-surface geometry, obtained in band-structure approaches, and (for the YBaCuO system) also corroborated by photoemission experiments. Using a large Coulomb-U, Fermi-liquid-based scheme, we present results for the q,ω and temperature dependence of the neutron cross section as well as for the temperature dependence of the NMR relaxation, in both cuprate families at various hole concentrations. When antiferromagnetic quasiparticle interactions of moderate strength are included, these calculations compare favorably with experiment. It should be stressed that the Fermi-surface shape must be accurately represented in both systems in order to produce this good agreement with the neutron data. We conclude that the close correspondence found, thus far, between band-structure-derived spin dynamics and the detailed fermiology of both cuprates provides support for Fermi-liquid-based schemes. Furthermore, this correspondence suggests important constraints which should be included in theoretical schemes ranging from the marginal and nearly antiferromagnetic Fermi liquid to more exotic scenarios for the normal state. Within this context, it is extremely important to determine the characteristic energy scales of the Fermi liquid. Comparison of our calculations with the measured energy scales of the spin dynamics indicates that these are sufficiently low so that one can reconcile deviations from canonical behavior above Tc with a Fermi-liquid ground state. Explicit effects of these low-energy scales are discussed in the context of the quasiparticle lifetime as a function of frequency and temperature. Our detailed studies also yield predictions for future experiments which will help to test futher the validity of this approach
The Interaction between the First Transmembrane Domain and the Thumb of ASIC1a Is Critical for Its N-Glycosylation and Trafficking
Acid-sensing ion channel-1a (ASIC1a), the primary proton receptor in the brain, contributes to multiple diseases including stroke, epilepsy and multiple sclerosis. Thus, a better understanding of its biogenesis will provide important insights into the regulation of ASIC1a in diseases. Interestingly, ASIC1a contains a large, yet well organized ectodomain, which suggests the hypothesis that correct formation of domain-domain interactions at the extracellular side is a key regulatory step for ASIC1a maturation and trafficking. We tested this hypothesis here by focusing on the interaction between the first transmembrane domain (TM1) and the thumb of ASIC1a, an interaction known to be critical in channel gating. We mutated Tyr71 and Trp287, two key residues involved in the TM1-thumb interaction in mouse ASIC1a, and found that both Y71G and W287G decreased synaptic targeting and surface expression of ASIC1a. These defects were likely due to altered folding; both mutants showed increased resistance to tryptic cleavage, suggesting a change in conformation. Moreover, both mutants lacked the maturation of N-linked glycans through mid to late Golgi. These data suggest that disrupting the interaction between TM1 and thumb alters ASIC1a folding, impedes its glycosylation and reduces its trafficking. Moreover, reducing the culture temperature, an approach commonly used to facilitate protein folding, increased ASIC1a glycosylation, surface expression, current density and slowed the rate of desensitization. These results suggest that correct folding of extracellular ectodomain plays a critical role in ASIC1a biogenesis and function
Neutron scattering and superconducting order parameter in YBa2Cu3O7
We discuss the origin of the neutron scattering peak at 41 meV observed in
YBaCuO below . The peak may occur due to spin-flip electron
excitations across the superconducting gap which are enhanced by the
antiferromagnetic interaction between Cu spins. In this picture, the experiment
is most naturally explained if the superconducting order parameter has -wave
symmetry and opposite signs in the bonding and antibonding electron bands
formed within a CuO bilayer.Comment: In this version, only few minor corrections and the update of
references were done in order to make perfect correspondence with the
published version. RevTeX, psfig, 5 pages, and 3 figure
Chemical transformations in monoterpene-derived organic aerosol enhanced by inorganic composition
Secondary organic aerosol (SOA) is known to impact both climate and air quality, yet molecular-level composition measurements remain challenging, hampering our understanding of SOA formation and evolution. Here, we reveal the importance of underestimated reaction pathways for the (trans) formation of SOA from monoterpenes, one of the largest SOA precursors globally. Utilizing mass spectrometric techniques to achieve a comprehensive characterization of molecular-level changes in the SOA, we were able to link the appearance of high-molecular weight (HMW) organic molecules to the concentration and level of neutralization of particulate sulfate. Interestingly, this oligomerization coincided with a decrease of highly oxygenated molecules (HOMs). Our findings highlight the role of particle-phase processing, and the underestimated importance of sulfate aerosol for monoterpene-SOA formation. The observations of these processes directly in the atmosphere reveal the need to account for the formation of HMW oligomers to fully understand the physicochemical properties of organic aerosol.Peer reviewe
The Dynamical Cluster Approximation: Non-Local Dynamics of Correlated Electron Systems
We recently introduced the dynamical cluster approximation(DCA), a new
technique that includes short-ranged dynamical correlations in addition to the
local dynamics of the dynamical mean field approximation while preserving
causality. The technique is based on an iterative self-consistency scheme on a
finite size periodic cluster. The dynamical mean field approximation (exact
result) is obtained by taking the cluster to a single site (the thermodynamic
limit). Here, we provide details of our method, explicitly show that it is
causal, systematic, -derivable, and that it becomes conserving as the
cluster size increases. We demonstrate the DCA by applying it to a Quantum
Monte Carlo and Exact Enumeration study of the two-dimensional Falicov-Kimball
model. The resulting spectral functions preserve causality, and the spectra and
the CDW transition temperature converge quickly and systematically to the
thermodynamic limit as the cluster size increases.Comment: 19 pages, 13 postscript figures, revte
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