2 research outputs found
ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΠΎΡΡΠΈΠ·ΠΎΠ»Π° Π² ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ΅ Ρ Π»ΠΈΠΏΠΎΠΏΡΠΎΡΠ΅ΠΈΠ½Π°ΠΌΠΈ ΠΎΡΠ΅Π½Ρ Π½ΠΈΠ·ΠΊΠΎΠΉ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΠΈ Π½Π° ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ Π³Π΅ΠΏΠ°ΡΠΎΠΌΡ Π½Π°-1 ΠΈ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ ΠΡΠ»ΠΈΡ Π°
Studies were conducted using ascetic HA-1 hepatomas and ascitic Ehrlichβs carcinoma cells. After passage of cells in mice, cell culture containing tumor-associated macrophages was studied. It was shown that the very low-density lipoprotein (VLDL)-cortisol complex significantly inhibited proliferative activity of tumor cells. The obtained constant of cortisol binding to VLDL indicated that the protein component of lipoproteins participated in the complex formation. Tumor-associated macrophages were suggested to play an important role in the formation of this complex. It was found that inhibition of tumor cell growth was related to apoptosis.ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈΡΡ Π½Π° ΠΊΠ»Π΅ΡΠΊΠ°Ρ
Π°ΡΡΠΈΡΠ½ΠΎΠΉ ΠΠ-1 Π³Π΅ΠΏΠ°ΡΠΎΠΌΡ ΠΈ Π°ΡΡΠΈΡΠ½ΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ ΠΡΠ»ΠΈΡ
Π°. ΠΠΎΡΠ»Π΅ ΠΏΠ°ΡΡΠ°ΠΆΠ° ΠΊΠ»Π΅ΡΠΎΠΊ Π½Π° ΠΌΡΡΠ°Ρ
Π²ΡΠ΄Π΅Π»ΡΠ»ΠΈ ΡΠΌΠ΅ΡΠ°Π½Π½ΡΡ ΠΊΡΠ»ΡΡΡΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΡΡ ΠΎΠΏΡΡ
ΠΎΠ»Ρ-Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ ΠΌΠ°ΠΊΡΠΎΡΠ°Π³ΠΈ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π² ΡΠΎΠΊΡΠ»ΡΡΡΡΠ΅ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡ ΠΠΠΠΠβΠΊΠΎΡΡΠΈΠ·ΠΎΠ» Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΏΠΎΠ΄Π°Π²Π»ΡΠ» ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ. ΠΠΎΠ»ΡΡΠ΅Π½Π½Π°Ρ ΠΊΠΎΠ½ΡΡΠ°Π½ΡΠ° ΡΠ²ΡΠ·Ρ- Π²Π°Π½ΠΈΡ ΠΊΠΎΡΡΠΈΠ·ΠΎΠ»Π° Ρ ΠΠΠΠΠ ΡΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π½Π° ΡΠΎ, ΡΡΠΎ Π² ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΡΠΈΠ½ΠΈΠΌΠ°Π΅Ρ ΡΡΠ°ΡΡΠΈΠ΅ Π±Π΅Π»ΠΊΠΎΠ²ΡΠΉ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ Π»ΠΈΠΏΠΎΠΏΡΠΎΡΠ΅ΠΈΠ½ΠΎΠ². ΠΡΠ΅Π΄ΠΏΠΎΠ»Π°Π³Π°Π΅ΡΡΡ, ΡΡΠΎ Π² ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠΈ ΡΠ°ΠΊΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° Π²Π°ΠΆΠ½ΡΡ ΡΠΎΠ»Ρ ΠΈΠ³ΡΠ°ΡΡ ΠΎΠΏΡΡ
ΠΎΠ»Ρ-Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ ΠΌΠ°ΠΊΡΠΎΡΠ°Π³ΠΈ. ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ, ΡΡΠΎ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌ ΠΏΠΎΠ΄Π°Π²Π»Π΅Π½ΠΈΡ ΡΠΎΡΡΠ° ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠ²ΡΠ·Π°Π½ Ρ Π°ΠΏΠΎΠΏΡΠΎΠ·ΠΎ
INFLUENCE OF CORTISOL AND VERY LOW-DENSITY LIPOPROTEINES ON THE DEVELOPMENT OF HA-1HEPATOMA AND EHRLICHβS CARCINOMA
Studies were conducted using ascetic HA-1 hepatomas and ascitic Ehrlichβs carcinoma cells. After passage of cells in mice, cell culture containing tumor-associated macrophages was studied. It was shown that the very low-density lipoprotein (VLDL)-cortisol complex significantly inhibited proliferative activity of tumor cells. The obtained constant of cortisol binding to VLDL indicated that the protein component of lipoproteins participated in the complex formation. Tumor-associated macrophages were suggested to play an important role in the formation of this complex. It was found that inhibition of tumor cell growth was related to apoptosis