New Model-Based Analysis Method with Multiple Constraints for Integrated Modular Avionics Dynamic Reconfiguration Process

With the development of integrated modular avionics (IMA), the dynamic reconfiguration of IMA not only provides great advantages in resource utilization and aircraft configuration, but also acts as a valid means for resource failure management. It is vital to ensure the correction of the IMA dynamic reconfiguration process. The analysis of the dynamic reconfiguration process is a significant task. The Architecture Analysis & Design Language (AADL) is widely used in complicated real-time embedded systems. The language can describe the system configuration and the execution behaviors, such as configuration changes. Petri net is a widely used tool to conduct simulation analysis in many aspects. In this study, a model-based analyzing method with multiple constraints for the IMA dynamic reconfiguration process was proposed. First, several design constraints on the process were investigated. Second, the dynamic reconfiguration process was modeled based on the AADL. Then, a set of rules for the transition of the model from AADL to Petri net was generated, and the multi-constraints proposed were incorporated into Petri net for analysis. Finally, a simulation multi-constraint analysis with Petri net for the process of IMA dynamic reconfiguration was conducted. Finally, a case study was employed to demonstrate this method. This method is advantageous to the validity of IMA dynamic reconfiguration at the beginning of the system design

Study of Surface Integrity of Titanium Alloy (TC4) by Belt Grinding to Achieve the Same Surface Roughness Range

Titanium alloy materials are used in a variety of engineering applications in the aerospace, aircraft, electronics, and shipbuilding industries, and due to the continuous improvement of the contemporary age, surface integrity needs to be improved for engineering applications. Belt grinding parameters and levels directly affect the surface integrity of titanium alloys (TC4), which further affects the fatigue life of the titanium alloys during service. In order to investigate the surface integrity of titanium alloys at different roughness levels, the surfaces were repeatedly ground with the same type and different models of abrasive belts. The results showed that at roughness Ra levels of 0.4 μm to 0.2 μm, the compressive residual stresses decreased with increasing linear velocity and there were problems with large surface morphological defects. At the roughness Ra of 0.2 μm or less, grinding improves the surface morphology, the compressive residual stress increases with increasing feed rate, and the surface hardness decreases with increasing linear velocity. In addition, the research facilitates the engineering of grinding parameters and levels that affect surface integrity under different roughness conditions, providing a theoretical basis and practical reference

Light Amplification with Low-Gain Material: Harvesting Harmonic Resonance Modes of Surface Plasmon Polaritons on a Magnetic Meta-Surface

We theoretically show that it is feasible to utilize harmonic resonance modes of surface plasmon polaritons on a magnetic meta-surface for light amplification with low-gain material. The required threshold and optimal gain strength for active layer can be substantially reduced to about one-tenth as compared with those utilizing fundamental resonance modes. The findings provide a simple and practical metamaterial approach for light amplification with most of the existing active media

sj-docx-1-taj-10.1177_20406223231189224 – Supplemental material for Comparison of the profiles of first-line PD-1/PD-L1 inhibitors for advanced NSCLC lacking driver gene mutations: a systematic review and Bayesian network meta-analysis

Supplemental material, sj-docx-1-taj-10.1177_20406223231189224 for Comparison of the profiles of first-line PD-1/PD-L1 inhibitors for advanced NSCLC lacking driver gene mutations: a systematic review and Bayesian network meta-analysis by Fu Wenfan, Xu Manman, Shi Xingyuan, Jiang Zeyong, Zhao Jian and Dai Lu in Therapeutic Advances in Chronic Disease</p

MiRNA 17 family regulates cisplatin-resistant and metastasis by targeting TGFbetaR2 in NSCLC.

MicroRNAs (miRNAs) have been proven to play crucial roles in cancer, including tumor chemotherapy resistance and metastasis of non-small-cell lung cancer (NSCLC). TGFβ signal pathway abnormality is widely found in cancer and correlates with tumor proliferation, apoptosis and metastasis. Here, miR-17, 20a, 20b were detected down-regulated in A549/DDP cells (cisplatin resistance) compared with A549 cells (cisplatin sensitive). Over-expression of miR-17, 20a, 20b can not only decrease cisplatin-resistant but also reduce migration by inhibiting epithelial-to-mesenchymal transition (EMT) in A549/DDP cells. These functions of miR-17, 20a, 20b may be caused at least in part via inhibition of TGFβ signal pathway, as miR-17, 20a, 20b are shown to directly target and repress TGF-beta receptor 2 (TGFβR2) which is an important component of TGFβ signal pathway. Consequently, our study suggests that miRNA 17 family (including miR-17, 20a, 20b) can act as TGFβR2 suppressor for reversing cisplatin-resistant and suppressing metastasis in NSCLC