The comparative study of the streptococcinum, Hepar sulfur, Rosmarinus officinalis and erythromycin effects on cultured rainbow trout (Oncorhynchus mykiss) with experimental streptococcusis.

The comparative study of the streptococcinum, Hepar sulfur, Rosmarinus officinalis and erythromycin effects on cultured rainbow trout (Oncorhynchus mykiss) with experimental streptococcosis Homeopathy is one of alternative medicines that is very useful for soul and body diseases with accurate prescription. The goal of this study was “survey of the effects of homeopathic remedies. There is not any more research about homeopathy on aquatics in the world especially in Iran, thus Some research about the effects of homeopathy on aquatics is needed. In this study, the effects of streptococcinum, Hepar sulfure, Rosmarinus officinalis(homeopathic remedies) and erythromycin in cultured rainbow trout, with experimental streptococcosis, also the mortality, were compared. There was 6 treatment and 2 reviews in 300 liter tanks that each of treatment contained 40 juvenile rainbow trout with 25±5 gr arrange weight. Treatment 1: contained of erythromycin. Treatment 2: Streptococcinum C30. Treatment 3: Rosmarinus officinalis Q. Treatment 4: Hepar sulfur C30 . Treatment 5:(control treatment )without any injection and any therapy. Treatment 6: (positive control treatment) with injection but without any therapy. Daily estimation of the water temperature, oxygen, pH and salinity and some other chemical factors. Tretment 1 had significance with the other treatments. Survival percent in treatments and their analysis showed that treatment 4(Hep-s) had significance (p<0.05) with treatment 3(Ros-off) and its survival percent is more than the other homeopathic remedies. Erythromycin is chemical drug and has many side effects but Hep-s has not any side effect and is an natural remedy for Streptococcosis in homeopathy. Thus we offer the Hep-s to cure the streptococcosis but some research with disk diffusion test about the different doses of Hep-s is needed. Daily survey of clinical symptoms such as hemorrhages in the external organs, Under eyes, under skin, under fins and gills, hemorrhages and exophthalmos, were the most symptoms. Important pathological symptoms were: necrosis, hyperplasia and melanosis in branches, liver and kidneys, hemorrhages in heart, kidneys and in visceral tissues. According to the survival results, there was significant difference between the treatment 1 and the other treatments (p<0.05). Also there was significant difference between treatment 3, treatment 4 and treatment 2(p<0.05), this difference is due to the high dose(Q) of R.officinalis, while the two other homeopathic remedies were in a moderated dose (C30), 30× 100 diluted dose. Survival percent of treatment 4(Hep-s) was more than the other homeopathic remedies and was related to erythromycin. Erythromycin is chemical medicine and has many side effects, while Hepar sulfur has not any side effects if the prescription would be accurate. Hep-s is suggested with disk diffusion tests for relief the symptoms of streptococcosis

Derivative UV/Vis spectroelectrochemistry in a thin-layer regime: deconvolution and simultaneous quantification of ascorbic acid, dopamine and uric acid

In this work, UV/Vis spectroelectrochemistry (SEC), in a thin-layer regime and parallel configuration, is selected to solve a complex mixture that contains dopamine (DA), ascorbic acid (AA) and uric acid (UA). These molecules, like many other biological compounds, are assuming a highly important place in analytical and biomedical fields due to the fundamental role that they play in human metabolism. In addition, low or high levels of these compounds are associated with diseases such as Parkinson’s disease. For this reason, the quantification of these biomolecules is becoming increasingly critical. However, some drawbacks must be overcome, because the three molecules coexist in the human body, and the species are subject to mutual interference. In fact, they are all oxidized at similar potentials, and their UV/Vis absorption bands overlap, greatly complicating their quantification. For this reason, derivative SEC together with suitable chemometric tools such as PARAFAC are proposed to solve this complex matrix. This technique allows us to separate the contribution of each of these molecules present in a sample and to quantify all of them, achieving high resolution and reproducibility. Besides, detection limits at the micromolar level are achieved for DA, AA and UA in mixture solutions. This work thus demonstrates the great potential for derivative potentiodynamic SEC combined with the appropriate chemometric tools in solving complex mixtures, a field where SEC is still taking the first steps.Ministerio de Economía y Competitividad (Grants CTQ2017-83935-RAEI/ FEDER, UE), Junta de Castilla y León (Grant BU297P18) and Ministerio de Ciencia, Innovación y Universidades (RED2018-102412- T). F.O. is grateful for the contract funded by Junta de Castilla y León, the European Social Fund and the Youth Employment Initiative. J.G.R. thanks theMinisterio de Economía y Competitividad for his postdoctoral contract (CTQ2017-83935-R AEI/FEDER, UE)

Changes in the Expression of Cyclooxygenase-2 in Polycystic Ovary Syndrome in Wistar Rats

Background: Cyclooxygenase 2 is a key enzyme which converts arachidonic acid into prostaglandins. Cyclooxygenase 2 is triggered by inflammatory stimuli, such as cytokines. Its expression increases in tumors and Alzheimer's disease and ovarian hyperstimulation syndrome. Polycystic ovarian syndrome is a heterogeneous disease characterized by pathological angiogenesis and chronic anovulation. In the present study, the probable role of cyclooxygenase 2 in Wistar rats with polycystic ovarian syndrome was investigated.Methods: Thirty female Wistar rats (170-200 gr) were equally divided into three groups: 2 mg estradiol valerate was intramuscularly administered to each rat in the experiment group or group 1; the rats in group 2 were regarded as the sham group and received sesame oil injections and group 3 or the control group received no injections. After 60 days of treatment, animals were anaesthetized with chloroform and killed by decapitation. Ovaries were collected for histological and immunohistochemical evaluations. All the experiments were repeated three times.Results: Morphologically, ovaries from the control group exhibited follicles in various stages of development and many fresh corpus luteum. In estradiol valerate group small follicles in early development were observed in addition to follicles showing evidence of atresia and many large cysts with thickened theca cell layer. Corpus luteum was rare or absent in group 2. The immunohistochemical analysis for cyclooxygenase 2 expression showed an increased expression of cyclooxygenase 2 enzyme in group 1.Conclusion: The results suggested the involvement of cyclooxygenase 2 in the progression to polycystic ovarian syndrome in a rat model

Prediction of blast-produced ground vibration using particle swarm optimization

Blasting operation is an inseparable operation of the rock fragmentation process in the surface mines and tunneling projects. Ground vibration is one of the most undesirable effects induced by blasting operation which can cause damage to the surrounding residents and structures. So, the ability to make precise predictions of ground vibration is very important to reduce the environmental side effects caused by mine blasting. The aim of this paper is to develop a simple, accurate, and applicable model based on particle swarm optimization (PSO) approach for predicting the ground vibration induced by blasting operations in Shur River dam region, Iran. In this regard, two forms of PSO models, linear and power, were developed. For this work, a database including 80 data sets was collected, and the values of the maximum charge weight used per delay (W), distance between blast-point and monitoring station (D) and peak particle velocity (PPV) were measured. To develop the PSO models, PPV was used as output parameter, while W and D were used as input parameters. To check the performance of the proposed PSO models, multiple linear regression (MLR) model and United States Bureau of Mines (USBM) equation were also developed. Accuracy of models established was evaluated using statistical criteria, i.e., coefficient of correlation (R2) and root mean square error (RMSE), variance absolute relative error (VARE) and Nash & Sutcliffe (NS). Finally, it was found that the PSO power form provided more accurate predictions in comparison with PSO linear form, MLR and USBM models

The effect of monolaurin in combination with Mentha pulegium L. and Mentha spicata L. essential oils on Bacillus cereus and E. coli O157:H7: in vitro study

Monolaurin, pennyroyal (Mentha pulegium L., Labiatae) and spearmint (Mentha spicata L.) essential oils have various antibacterial activities on microorganisms. Enhancement of antibacterial activity and detection of their combined effects on B.cereus ATCC 11778 and E. coli O157:H7 were the purpose of this investigation. Monolaurin preparation, spearmint and pennyroyal essential oils preparation and analysis of their chemical composition with GC-MS method, bacterial inoculums preparation, antimicrobial susceptibility testing using broth micro dilution MIC testing and finally statistic analysis of results with SPSS software package were the material and methods used in this research. MIC (minimum inhibitory concentration) of pennyroyal oil, spearmint oil, monolaurin, monolaurin-pennyroyal oil combination and monolaurin-spearmint oil combination on B.cereus and E. coli O157:H7 were significant (

SemEval-2022 Task 8: multilingual news article similarity

Thousands of new news articles appear daily in outlets in different languages. Understanding which articles refer to the same story can not only improve applications like news aggregation but enable cross-linguistic analysis of media consumption and attention. However, assessing the similarity of stories in news articles is challenging due to the different dimensions in which a story might vary, e.g., two articles may have substantial textual overlap but describe similar events that happened years apart. To address this challenge, we introduce a new dataset of nearly 10,000 news article pairs spanning 18 language combinations annotated for seven dimensions of similarity as SemEval 2022 Task 8. Here, we present an overview of the task, the best performing submissions, and the frontiers and challenges for measuring multilingual news article similarity. While the participants of this SemEval task contributed very strong models, achieving up to 0.818 correlation with gold standard labels across languages, human annotators are capable of reaching higher correlations, suggesting space for further progress