16 research outputs found
Automated Three-Dimensional Reconstruction of the Left Ventricle From Multiple-Axis Echocardiography
Production performance analysis of sheep MSTN gene C2361T locus
The myostatin (MSTN) gene exhibits significant nucleotide sequence variations in sheep, impacting growth characteristics and muscular traits of the body. However, its influence on specific growth traits in some sheep remains to be further elucidated. This study utilized single nucleotide polymorphism sequence analysis to investigate the role of the MSTN gene in meat production performance across four sheep breeds: Charolais sheep, Australian White sheep, crossbreeds of Australian White and Small-tailed Han, and crossbreeds of Charolais and Small-tailed Han. At a SNP locus of the MSTN gene, the C2361T site was identified, with three genotypes detected: CC, CT, and TT, among which CC predominated. Gene substitution effect analysis revealed that replacing C with T could elevate the phenotypic value. Comparative analysis of data from different genotypes within the same breed highlighted the superiority of CC and TT genotypes in phenotypic values, underscoring the significance of specific genotypes in influencing key traits. Contrasting the performance of different genotypes across breeds, Charolais sheep and Charolais Han hybrids demonstrated superiority across multiple indicators, offering valuable insights for breeding new sheep varieties. Analysis of gender effects on growth characteristics indicated that ewes exhibited significantly wider chest, waist, and hip widths compared to rams, while rams displayed better skeletal growth and muscle development. Additionally, the MSTN gene also exerted certain effects on lamb growth characteristics, with the CC genotype closely associated with weight. These findings not only contribute crucial insights for sheep breeding but also pave the way for future research exploring the interaction of this gene with others
Wearable PerovskiteâBased Shadow Recognition Sensor for Ambient and Nonobtrusive HumanâComputer Interaction
Driven by the Internet of Everything, one of the main goals in humanâcomputer interaction is to achieve intuitive, effortless, and easyâtoâlearn communication. Thus, senseless optoelectronic devices with high response performance under ambient environment have an extensive application space in improving the interfacing between users and computers. Herein, a concept of wearable perovskiteâbased shadow recognition sensor is demonstrated for ambient and nonobtrusive humanâcomputer interaction. The multidimensional ordered nucleation and growth of perovskite crystals are promoted by introducing the selfâdriving effect of liquid crystal (LC) oligomers. The resulted LCâdoped perovskite film (LCâPVK) with micrometerâsized grains can output relatively high photocurrent under indoor ambient light (â500âlux). The LCâbased device exhibits over a hundred times of onâoff ratio and fast response of millisecond level even after storage for more than 1200âh. The device also shows an ultratrace Pb2+ leakage of 1.02âÎŒgâLâ1 in water, and still retains more than 90% of the photocurrent intensity after thousands of bending strains. Accordingly, a novel humanâcomputer interaction is achieved by identifying external action commands with the recognition of shadows, which can provide a âhapticâ perception for robots
All-printed point-of-care immunosensing biochip for one drop blood diagnostics
Designing and preparing a fast and easy-to-use immunosensing biochip are of great significance for clinical diagnosis and biomedical research. In particular, sensitive, specific, and early detection of biomarkers in trace samples promotes the application of point-of-care testing (POCT). Here, we demonstrate an all-printed immunosensing biochip with the characteristics of hydrodynamic enrichment and photonic crystal-enhanced fluorescence. Direct quantitative detection of cardiac biomarkers via one drop of blood is achieved in 10 min. After simulating the hydrodynamic behavior of one droplet serum on the printed assay, creatine kinase-MB (CK-MB) has been recognized and located on the photonic crystal arrays. Benefiting from the fluorescence enhancement effect, quantitative detection of CK-MB has been demonstrated from 0.01 ng ml(-1) to 100 ng ml(-1), which is superior to the conventional enzyme-linked immunosorbent assay (ELISA). This strategy provides a general and easy-to-use approach for fast quantitative detection of biomarkers, which would be improved further for portable clinical diagnostics and home medical monitoring.ISSN:1473-0197ISSN:1473-018
Lateral Heterostructured VisâNIR Photodetectors with Multimodal Detection for Rapid and Precise Classification of Glioma
Precise
diagnosis of the boundary and grade of tumors
is especially
important for surgical dissection. Recently, visible and near-infrared
(VisâNIR) absorption differences of tumors are demonstrated
for a precise tumor diagnosis. Here, a template-assisted sequential
printing strategy is investigated to construct lateral heterostructured
VisâNIR photodetectors, relying on the up-conversion nanoparticles
(UCNPs)/perovskite arrays. Under the sequential printing process,
the synergistic effect and co-confinement are demonstrated to induce
the UCNPs to cover both sides of the perovskite microwire. The side-wrapped
lateral heterogeneous UCNPs/perovskite structure exhibits more satisfactory
responsiveness to VisâNIR light than the common fully wrapped
structure, due to sufficient visible-light-harvesting ability. The
VisâNIR photodetectors with R reaching 150
mA Wâ1 at 980 nm and 1084 A Wâ1 at 450 nm are employed for the rapid classification of glioma. The
detection accuracy rate of 99.3% is achieved through a multimodal
analysis covering the VisâNIR light, which provides a reliable
basis for glioma grade diagnosis. This work provides a concrete example
for the application of photodetectors in tumor detection and surgical
diagnosis
Lateral Heterostructured VisâNIR Photodetectors with Multimodal Detection for Rapid and Precise Classification of Glioma
Precise
diagnosis of the boundary and grade of tumors
is especially
important for surgical dissection. Recently, visible and near-infrared
(VisâNIR) absorption differences of tumors are demonstrated
for a precise tumor diagnosis. Here, a template-assisted sequential
printing strategy is investigated to construct lateral heterostructured
VisâNIR photodetectors, relying on the up-conversion nanoparticles
(UCNPs)/perovskite arrays. Under the sequential printing process,
the synergistic effect and co-confinement are demonstrated to induce
the UCNPs to cover both sides of the perovskite microwire. The side-wrapped
lateral heterogeneous UCNPs/perovskite structure exhibits more satisfactory
responsiveness to VisâNIR light than the common fully wrapped
structure, due to sufficient visible-light-harvesting ability. The
VisâNIR photodetectors with R reaching 150
mA Wâ1 at 980 nm and 1084 A Wâ1 at 450 nm are employed for the rapid classification of glioma. The
detection accuracy rate of 99.3% is achieved through a multimodal
analysis covering the VisâNIR light, which provides a reliable
basis for glioma grade diagnosis. This work provides a concrete example
for the application of photodetectors in tumor detection and surgical
diagnosis