Additional file 2 of Lactiplantibacillus plantarum enables blood urate control in mice through degradation of nucleosides in gastrointestinal tract

Additional file 2: Figure S1. Changes in metabolic parameters due to high nucleosides diet and L. plantarum supplementation in mice. Supplementary Fig. 2. Changes in gut microbiota due to high nucleosides diet and L. plantarum supplementation in mice. Supplementary Fig. 3. L. plantarum affecting the gut metabolites. Supplementary Fig. 4. Metagenomic functional annotation and classification of L. plantarum in KEGG (A) and in COG (B). Supplementary Fig. 5. Identification of production of inosine hydrolyzed by L. plantarum. Supplementary Fig. 6. Established Caco-2 cell monolayer for nucleosides and nucleobases transport. Supplementary Fig. 7. Gene sequences alignment of RihA–C from L. plantarum with other organisms

Additional file 1 of Lactiplantibacillus plantarum enables blood urate control in mice through degradation of nucleosides in gastrointestinal tract

Additional file 1: Table S1. Primer sequence of genes in this work. Table S2. Fifteen differential genera in mice supplemented L. plantarum when compared with HNS mice. Table S3. Taxonomy of six microbes using NCBI Nucleotide BLAST analysis tool. Table S4. Three genes involved with nucleoside degradation in L. plantarum. Table S5. Annotated genes contributed to the nucleotide and nucleoside metabolism, which showed that no enzyme in L. plantarum enable to catalyze the transformation of guanine and hypoxanthine into xanthine and resultant urate. Table S6. Genes involved with purine permeation in L. plantarum. Table S7. Permeation for nucleobases in L. plantarum within 2 hours. Table S8. Solubility of nucleosides and nucleobases in water. Table S9. Nodes information in multi-omic network analysis given by Fig. 2A. Table S10. Edges information in multi-omic network analysis given by Fig. 2A. Table S11. Nodes information in multi-omic network analysis given by Fig. S3C. Table S12. Edges information in multi-omic network analysis given by Fig. 3C