The relationship between body-mass index and Helicobacter pylori infection: a case-control study

Objective: Helicobacter pylori infection is one of the most common infections worldwide. There are different opinions in the literature aboutthe relationship between H. pylori and obesity. In this study, we investigated the relationship between body-mass index (BMI) and H. pyloriinfection.Material and Method: A cross-sectional study was conducted among patients who underwent endoscopic examinations at Tekirdağ NamıkKemal University Faculty of Medicine Hospital in 2019. The prevalence of H. pylori infection was examined by biopsy. The relationshipbetween BMI and H. pylori infection was analyzed.Results: 51.8% of the cases in our population were positive for H. pylori infection. On histopathological examination, acute and chronicinflammation findings were higher in H. pylori-positive cases compared to H. pylori-negative cases. The prevalence of H. pylori infectionwas higher in patients with high BMI than those with low BMI. Statistical analysis showed a significant relationship between BMI and theprevalence of H. pylori infection (p<0.001), and there was a positive linear correlation between these two parameters (r=0.542). When therisk factors were examined univariable, BMI was found to be a significant risk factor for H. pylori infection (p=0.008). Multivariable analysisresults revealed that BMI is an independent risk factor for H. pylori infection. (OR=1.32 (1.09-3.46), p=0.025).Conclusion: Our results showed that there is a significant relationship between BMI and H. pylori infection, and high BMI is an independentrisk factor for H. pylori infection

PD-1 and PD-L2 expression predict relapse risk and poor survival in patients with stage III colorectal cancer

Background Immune responses have long been an area of interest in cancer research. In this study, the effects of programmed cell death-1 (PD-1) and its ligand (PD-L2) on the prognosis of colorectal cancer (CRC) were investigated. Methods Primary tumour specimens of stage III CRC patients operated between 2002 and 2013 were assessed for PD-1 and PD-L2 expression and various clinicopathological and prognostic factors. Results We observed a significant relationship between poor prognostic factors and PD-1/PD-L2 expression. These biomarkers were also found to serve as independent risk factors for LIR and MSI. In univariate analysis, relapse-free survival (RFS) and overall survival (OS) rates were found to be poor in PD-1 and PD-L2 positive patients. In multivariate analysis, these biomarkers were found to serve as independent poor prognostic factors for RFS and OS. Conclusions Our data indicate that PD-1 and PD-L2 may serve as independent prognostic survival parameters for CRC patients and may be employed for the design of targeted theapies.Kirikkale Universit

Placental Chorioangioma: A Case Report and Literature Review

When placental masses are discovered during routine conventional sonographic examination, differentiation between chorioangiomas and other lesions is not always possible. Absolute identification should be done prenatally by color flow mapping for every suspected placental mass. Because unidentif ied large chorioangiomas can cause more tragic perinatal complications compared to other placental lesions