158 research outputs found
X-ray diffraction study of crystallite size-distribution and strain in carbon blacks
The crystallite size and size-distribution in the presence of strain is determined in carbon
blacks by a recently developed procedure of X-ray diffraction peak profile analysis. The Fourier
coefficients of the measured physical profiles are fitted by Fourier coefficients of well
established ab initio functions of size and strain peak profiles. Strain anisotropy is accounted for
by the dislocation model of the mean square strain in terms of average dislocation contrast
factors. Crystallite shape anisotropy is modelled by ellipsoids incorporated into the size profile
function. The Fourier transforme of the size profile is given as an explicite formula making the
fitting procedure fast. The method is applied to carbon balcks terated at different preassures and
temperatures. The microstructure is characterised in terms of crystallite size-distribution,
dislocation density and crystallite shape anisotropy
Properties of nanostructured diamond-silicon carbide composites sintered by high pressure infiltration technique
A high-pressure silicon infiltration technique was applied to sinter diamond–SiC composites with different diamond crystal sizes. Composite samples were sintered at pressure 8 GPa and temperature 2170 K. The structure of composites was studied by evaluating x-ray diffraction peak profiles using Fourier coefficients of ab initio theoretical size and strain profiles. The composite samples have pronounced nanocrystalline structure: the volume-weighted mean crystallite size is 41–106 nm for the diamond phase and 17–37 nm for the SiC phase. The decrease of diamond crystal size leads to increased dislocation density in the diamond phase, lowers average crystallite sizes in both phases, decreases composite hardness, and improves fracture toughness
Microstructure of nanocrystalline diamond powders studied by powder diffractometry
High resolution x-ray diffraction peaks of diamond nanosize powders of nominal sizes ranging from 5 to 250 nm were analyzed and provided information on grain structure, average size of crystallites, and concentration of dislocations. Selected samples were heat treated at 1670 K at pressures 2.0 and 5.5 GPa or had surface modified by outgassing, heat treatment at vacuum conditions, and by controlled adsorption of gases. The apparent lattice parameter method was applied to characterize the structure of a shell-core model of nanosize particles. The multiple whole profile fitting provided information on crystallite sizes and density of dislocations. Population of dislocations increased with applied pressure, while strain and interplanar distances in the surface layers decreased. Adsorption of foreign gases on the grain surface modified the structure of the surface layers but did not affect dislocations near the center of the grains
Dislocation density and graphitization of diamond crystals
Two sets of diamond specimens compressed at 2 GPa at temperatures varying between 1060 K and 1760 K were prepared; one in which graphitization was promoted by the presence of water and another in which graphitization of diamond was practically absent. X-ray diffraction peak profiles of both sets were analyzed for the microstructure by using the modified Williamson-Hall method and by fitting the Fourier coefficients of the measured profiles by theoretical functions for crystallite size and lattice strain. The procedures determined mean size and size distribution of crystallites as well as the density and the character of the dislocations. The same experimental conditions resulted in different microstructures for the two sets of samples. They were explained in terms of hydrostatic conditions present in the graphitized samples
GPU-based ultra fast dose calculation using a finite pencil beam model
Online adaptive radiation therapy (ART) is an attractive concept that
promises the ability to deliver an optimal treatment in response to the
inter-fraction variability in patient anatomy. However, it has yet to be
realized due to technical limitations. Fast dose deposit coefficient
calculation is a critical component of the online planning process that is
required for plan optimization of intensity modulated radiation therapy (IMRT).
Computer graphics processing units (GPUs) are well-suited to provide the
requisite fast performance for the data-parallel nature of dose calculation. In
this work, we develop a dose calculation engine based on a finite-size pencil
beam (FSPB) algorithm and a GPU parallel computing framework. The developed
framework can accommodate any FSPB model. We test our implementation on a case
of a water phantom and a case of a prostate cancer patient with varying beamlet
and voxel sizes. All testing scenarios achieved speedup ranging from 200~400
times when using a NVIDIA Tesla C1060 card in comparison with a 2.27GHz Intel
Xeon CPU. The computational time for calculating dose deposition coefficients
for a 9-field prostate IMRT plan with this new framework is less than 1 second.
This indicates that the GPU-based FSPB algorithm is well-suited for online
re-planning for adaptive radiotherapy.Comment: submitted Physics in Medicine and Biolog
High Performance In Vivo Near-IR (>1 {\mu}m) Imaging and Photothermal Cancer Therapy with Carbon Nanotubes
Short single-walled carbon nanotubes (SWNTs) functionalized by PEGylated
phospholipids are biologically non-toxic and long-circulating nanomaterials
with intrinsic near infrared photoluminescence (NIR PL), characteristic Raman
spectra, and strong optical absorbance in the near infrared (NIR). This work
demonstrates the first dual application of intravenously injected SWNTs as
photoluminescent agents for in vivo tumor imaging in the 1.0-1.4 {\mu}m
emission region and as NIR absorbers and heaters at 808 nm for photothermal
tumor elimination at the lowest injected dose (70 {\mu}g of SWNT/mouse,
equivalent to 3.6 mg/kg) and laser irradiation power (0.6 W/cm2) reported to
date. Ex vivo resonance Raman imaging revealed the SWNT distribution within
tumors at a high spatial resolution. Complete tumor elimination was achieved
for large numbers of photothermally treated mice without any toxic side effects
after more than six months post-treatment. Further, side-by-side experiments
were carried out to compare the performance of SWNTs and gold nanorods (AuNRs)
at an injected dose of 700 {\mu}g of AuNR/mouse (equivalent to 35 mg/kg) in NIR
photothermal ablation of tumors in vivo. Highly effective tumor elimination
with SWNTs was achieved at 10 times lower injected doses and lower irradiation
powers than for AuNRs. These results suggest there are significant benefits of
utilizing the intrinsic properties of biocompatible SWNTs for combined cancer
imaging and therapy.Comment: Nanoresearch, in pres
Implementation and evaluation of various demons deformable image registration algorithms on GPU
Online adaptive radiation therapy (ART) promises the ability to deliver an
optimal treatment in response to daily patient anatomic variation. A major
technical barrier for the clinical implementation of online ART is the
requirement of rapid image segmentation. Deformable image registration (DIR)
has been used as an automated segmentation method to transfer tumor/organ
contours from the planning image to daily images. However, the current
computational time of DIR is insufficient for online ART. In this work, this
issue is addressed by using computer graphics processing units (GPUs). A
grey-scale based DIR algorithm called demons and five of its variants were
implemented on GPUs using the Compute Unified Device Architecture (CUDA)
programming environment. The spatial accuracy of these algorithms was evaluated
over five sets of pulmonary 4DCT images with an average size of 256x256x100 and
more than 1,100 expert-determined landmark point pairs each. For all the
testing scenarios presented in this paper, the GPU-based DIR computation
required around 7 to 11 seconds to yield an average 3D error ranging from 1.5
to 1.8 mm. It is interesting to find out that the original passive force demons
algorithms outperform subsequently proposed variants based on the combination
of accuracy, efficiency, and ease of implementation.Comment: Submitted to Physics in Medicine and Biolog
Optical Drug Monitoring: Photoacoustic Imaging of Nanosensors to Monitor Therapeutic Lithium in Vivo
Personalized medicine could revolutionize how primary care physicians treat chronic disease and how researchers study fundamental biological questions. To realize this goal, we need to develop more robust, modular tools and imaging approaches for in vivo monitoring of analytes. In this report, we demonstrate that synthetic nanosensors can measure physiologic parameters with photoacoustic contrast, and we apply that platform to continuously track lithium levels in vivo. Photoacoustic imaging achieves imaging depths that are unattainable with fluorescence or multiphoton microscopy. We validated the photoacoustic results that illustrate the superior imaging depth and quality of photoacoustic imaging with optical measurements. This powerful combination of techniques will unlock the ability to measure analyte changes in deep tissue and will open up photoacoustic imaging as a diagnostic tool for continuous physiological tracking of a wide range of analytes
A practical guide to photoacoustic tomography in the life sciences
The life sciences can benefit greatly from imaging technologies that connect microscopic discoveries with macroscopic observations. One technology uniquely positioned to provide such benefits is photoacoustic tomography (PAT), a sensitive modality for imaging optical absorption contrast over a range of spatial scales at high speed. In PAT, endogenous contrast reveals a tissue's anatomical, functional, metabolic, and histologic properties, and exogenous contrast provides molecular and cellular specificity. The spatial scale of PAT covers organelles, cells, tissues, organs, and small animals. Consequently, PAT is complementary to other imaging modalities in contrast mechanism, penetration, spatial resolution, and temporal resolution. We review the fundamentals of PAT and provide practical guidelines for matching PAT systems with research needs. We also summarize the most promising biomedical applications of PAT, discuss related challenges, and envision PAT's potential to lead to further breakthroughs
How non-native English-speaking staff are evaluated in linguistically diverse organizations: A sociolinguistic perspective
The aim of this paper is to examine the effects of evaluations of non-native speaking staff?s spoken English in international business settings. We adopt a sociolinguistic perspective on power and inequalities in linguistically diverse organizations in an Anglophone environment. The interpretive qualitative study draws on 54 interviews with non-native English-speaking staff in 19 UK business schools. We analyze, along the dimensions of status, solidarity and dynamism, the ways in which non-native speakers, on the basis of their spoken English, are evaluated by themselves and by listeners. We show how such evaluations refer to issues beyond the speaker?s linguistic fluency, and have consequences for her or his actions. The study contributes to the literature on language and power in international business through offering fine-grained insights into and elucidating how the interconnected evaluative processes impact the formation and perpetuation of organizational power relations and inequalities. It also puts forward implications for managing the officially monolingual, yet linguistically diverse organizations
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