Determination of The Relationship Between Hopelessness-Depression Frequency and Socio- Demographic Features in Students of School of Medicine, Suleyman Demirel University

Aim:Depression and hopelessness, cause impairment in the quality of life and leads to the loss of one's efficiency are important problems. The purpose of this study is to search the frequency of depression and hopelessness and its relations with socio-demographic characteristics among medical students.Materials and Methods:This is a cross sectional analytical study. It was conducted 2-4 March 2009 between. 1st, 2nd, and 3rd year students from the Faculty of Medicine, Suleyman Demirel University were included in the study. 236 of a total 330 students (68.5 %) participated in the study. A questionnaire which aims to determine the students’ socio-demographic characteristics, Beck depression inventory and Beck hopelessness scale were applied under observation to the participants. According to the Beck depression inventory, those who scored 17 and over were classified as possible depressive. Data were evaluated statistically.Results:The average score of the students according to Beck hopelessness scale was found 5.3±4.6. According to Beck depression inventory 64 of the students (28.3%) were found to be possible depressive. The average Beck hopelessness scale score was higher for possible depressive students compared to the others (p=0.00). Depression scores was higher among the first year students compared to the others (p=0.03), higher among the females compared the males (p=0.02) and higher among dwelling in dorm compared to not dwelling in dorm (p=0.001). When the age of students, monthly income of family, the educational status of the parents were compared with hopelessness and depression rates there was no statistically significant relation.Conclusion:As a result, depression rates were high in basic medical students, furthermore hopelessness scores were found high among possible depressive students. Medical students should be given guidance and counseling service. Effective monitoring and prevention programs should be developed in order to lower the possible effects of depression and hopelessness on their future professional lives

Determination of The Relationship Between Hopelessness-Depression Frequency and SocioDemographic Features in Students of School of Medicine, Suleyman Demirel University

Amaç Depresyon ve umutsuzluk kişinin verimliliğini kaybetmesine, yaşam kalitesinin bozulmasına neden olan önemli problemlerdir. Bu çalışmanın amacı tıp fakültesi öğrencilerinde depresyon ve umutsuzluk sıklığını ve sosyodemografik özelliklerle arasındaki ilişkiyi araştırmaktır. Materyal ve Metod Kesitsel-analitik tipte olan bu çalışma 02–04 Mart 2009 tarihleri arasında yürütüldü. Süleyman Demirel Üniversitesi Tıp Fakültesi birinci, ikinci ve üçüncü sınıf öğrencileri çalışmaya dahil edildi. Çalışmaya 330 öğrenciden 226’sı (% 68,5) katıldı. Öğrencilere, sosyodemografik özelliklerini saptamaya yönelik anket formu, Beck Depresyon Ölçeği, Beck Umutsuzluk Ölçeği gözlem altında uygulandı. Beck depresyon ölçeğine göre 17 ve üzeri puan alanlar olası depresif olarak sınıflandırıldı. Veriler istatistiksel olarak değerlendirildi. Bulgular Öğrencilerin Beck umutsuzluk ölçeği puan ortalamaları 5,3±4,6 bulundu. Beck depresyon ölçeğine göre 64’ü (%28,3) olası depresif bulundu. Olası depresif olanlarda Beck umutsuzluk ölçeği puan ortalaması normal olanlara göre daha yüksekti (p=0.00). Birinci sınıf öğrencilerinde diğer sınıflardaki öğrencilere göre (p=0.03), kızlarda erkeklere göre (p=0.02), yurtta kalan öğrencilerde ise yurtta kalmayanlara göre (p=0.001) depresyon puanları daha yüksek bulundu. Öğrencilerin yaşları, ailenin aylık gelir düzeyleri, ebeveynlerinin öğrenim durumları ile umutsuzluk ve depresyon oranları karşılaştırıldığında aralarında istatistiksel olarak anlamlı bir ilişki bulunmadı. Sonuç Sonuç olarak, temel tıp öğrencilerinde depresyon oranı yüksek olmakla birlikte, olası depresif öğrencilerde umutsuzluk puanları da yüksek bulunmuştur. Tıp öğrencilerine rehberlik ve danışmanlık hizmetlerinin verilmesi, mezuniyet sonrası depresyon ve umutsuzluğun mesleki yaşantılarına olabilecek etkilerini azaltmaya yönelik etkili önleme ve izleme programlarının geliştirilmesi uygun olacaktır.Aim Depression and hopelessness, cause impairment in the quality of life and leads to the loss of one's efficiency are important problems. The purpose of this study is to search the frequency of depression and hopelessness and its relations with socio-demographic characteristics among medical students. Materials and Methods This is a cross sectional analytical study. It was conducted 2-4 March 2009 between. 1st, 2nd, and 3rd year students from the Faculty of Medicine, Suleyman Demirel University were included in the study. 236 of a total 330 students (68.5 %) participated in the study. A questionnaire which aims to determine the students’ socio-demographic characteristics, Beck depression inventory and Beck hopelessness scale were applied under observation to the participants. According to the Beck depression inventory, those who scored 17 and over were classified as possible depressive. Data were evaluated statistically. Results The average score of the students according to Beck hopelessness scale was found 5.3±4.6. According to Beck depression inventory 64 of the students (28.3%) were found to be possible depressive. The average Beck hopelessness scale score was higher for possible depressive students compared to the others (p=0.00). Depression scores was higher among the first year students compared to the others (p=0.03), higher among the females compared the males (p=0.02) and higher among dwelling in dorm compared to not dwelling in dorm (p=0.001). When the age of students, monthly income of family, the educational status of the parents were compared with hopelessness and depression rates there was no statistically significant relation. Conclusion As a result, depression rates were high in basic medical students, furthermore hopelessness scores were found high among possible depressive students. Medical students should be given guidance and counseling service. Effective monitoring and prevention programs should be developed in order to lower the possible effects of depression and hopelessness on their future professional lives

Examination of the specific clinical symptoms and laboratory findings of Crimean-Congo hemorrhagic fever

Background & objectives: Crimean-Congo hemorrhagic fever (CCHF) is a fatal disease, caused by a tick-borne virus (Nairovirus), having a high mortality rate. The study was aimed to evaluate the risk factors, the presenting symptoms and findings of the patients with prediagnosis of CCHF disease, and to compare these variables between the CCHF-positive and CCHF-negative patients. It was also aimed to develop a scoring formula for the diagnosis of CCHF. Methods: In total, 281 patients who were admitted to the Sabuncuoglu Serafeddin Training and Research Hospital, Amasya, Turkey between 2011 and 2015 and were prediagnosed with CCHF based on the clinical symptoms, laboratory findings and risk factors were included in the study. The definitive laboratory diagnosis of patients with prediagnosis of CCHF was ensured via molecular and serological methods. In addition, a mathematical diagnostic scoring formula was developed for enhancing the laboratory results of CCHF. Results: The ratio of certain clinical symptoms such as fever (p<0.001), headache (p<0.001), widespread body pain (p<0.001), fatigue (p = 0.001), nausea and vomiting (p = 0.013) in CCHF-positive patients were found to be significantly higher compared to the ratio in CCHF-negative patients. In terms of laboratory findings such as presence of leucopenia (p<0.001), creatine kinase (CK) elevation (p<0.001), thrombocytopenia (p<0.001), aspartate aminotransferase/alanine aminotransferase (AST/ALT) elevation (p<0.001), lactate dehydrogenase (LDH) levels (p = 0.002), absence of abnormal findings on chest radiograph (p = 0.042), and the absence of anaemia (p = 0.007), the CCHF-positive patients had higher rates in comparison to CCHF-negative ones. Interpretation & conclusion: It was inferred that certain clinical symptoms and laboratory findings such as fever, headache, widespread body pain, fatigue, leucopenia, nausea, vomiting, high CK levels, thrombocytopenia, AST/ ALT elevation and elevated LDH levels are highly specific and are required to be considered in the definitive diagnosis of CCHF, particularly in regions where this infection is observed as endemic

Effects of Laparoscopic Gastric Band Applications on Plasma and Fundic Acylated Ghrelin Levels in Morbidly Obese Patients

It has been proposed that laparoscopic adjustable gastric banding (LAGB) procedure might play a role in modulation of fundic ghrelin production. To test this hypothesis, we examined plasma and tissue concentrations of acylated ghrelin in morbidly obese patients before and 6 months after LAGB. Baseline levels of acylated ghrelin in morbidly obese patients were also compared with those in age-matched, healthy, non-obese controls

The effects on oxidative DNA damage of laparoscopic gastric band applications in morbidly obese patients

Background: Obesity may induce oxidative stress, causing oxidative damage of DNA. We examined associations between decreasing serum and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels and weight loss in morbidly obese patients before and 6 months after laparoscopic adjustable gastric banding (LAGB). Methods: We compared patients who had surgery for morbid obesity with healthy, nonobese controls. Urine and fasting blood samples were collected once from the controls and from the morbidly obese patients before and 6 months after the LAGB. The serum and urinary 8-OHdG levels were evaluated in these groups using an enzyme-linked immunosorbent assay kit. Results: We included 20 patients who had surgery for morbid obesity (8 men, 12 women, mean body mass index [BMI] 46.82 +/- 4.47) and 20 healthy, nonobese people (10 men, 10 women, mean BMI 22.52 +/- 2.08) in our study. There was no significant difference in serum 8-OHdG levels between the groups, whereas urinary 8-OHdG levels were significantly higher in morbidly obese patients than in controls. Weight, BMI and serum and urinary 8-OHdG levels were significantly decreased in morbidly obese patients 6 months after LAGB. Conclusion: The LAGB provides efficient weight loss in patients with morbid obesity. The systemic oxidative DNA damage was increased by the morbid obesity, but this increase was not related to weight gain, and it was more evident in serum than urine samples. After LAGB for morbid obesity, the oxidative DNA damage declined both in serum and urine.Research Fund of Istanbul UniversityIstanbul University [3133]This work was supported by The Research Fund of Istanbul University (project number: 3133).WOS:0003377489000162-s2.0-84904367089PubMed: 2486961

Investigation of zinc and copper levels in methimazole-induced hypothyroidism: Relation with the oxidant-antioxidant status

Thyroid hormones are associated with the oxidative and antioxidative status of the organism. Depression of metabolism by hypothyroidism has been reported to decrease oxidant production and thus protect tissues against oxidant damage. The purpose of the present study was to investigate Zn and Cu levels in MMI-induced hypothyroidism and to show whether there is a connection between these trace elements and the oxidant-antioxidant status in experimental hypothyroidism. 3-Nitrotyrosine was measured as a marker of nitro-oxidative stress. In order to examine the antioxidant status of MMI-induced hypothyroidism in rats, GSH and SOD levels were determined as well. Significantly decreased 3-nitrotyrosine, Cu and Zn levels were observed in our experimental model when compared with the controls. On the other hand, GSH and SOD levels remained constant. It may be suggested that Cu and Zn serve as antioxidant molecules and exert their effects in an indirect manner to reduce oxidative stress in experimental hypothyroidism