21 research outputs found
Interventional Treatment of a Failing Pulmonic and Tricuspid Bioprosthesis in Hedinger Syndrome
Heart failure in adults with congenital heart disease: a narrative review.
The number of adults with congenital heart disease (ACHD) has increased over the last decades due to advancements in medical care, including interventional and surgical therapies. We are therefore more frequently challenged by the long-term consequences of palliative or corrective surgery carried out during childhood. Although patients with ACHD may develop conditions related to general cardiovascular risk factors, such as coronary artery disease, the most common complications leading to morbidity and mortality are arrhythmias, heart failure and thromboembolic events. For the management of arrhythmias, current recommendations regarding ablation and device therapy must be considered, whilst also taking into account the anatomical limitations of their congenital heart defect or surgical pathways. Heart failure treatment in acute and chronic settings must also consider the particular anatomy present, including the nature of the systemic ventricle. Treatments strategies for ACHD are typically extrapolated from the respective guidelines in non-ACHD patients, despite a lack of evidence to support this strategy. Right heart failure can be especially challenging to manage in conditions where either a systemic right ventricle or shunt lesions resulting in volume and/or pressure loading of the right ventricle are present. All physicians and cardiologists in particular should be acquainted with the most common diseases in ACHD, their complications and management regime, especially with regards to heart failure as this is a common reason for acute presentation in the emergency department
The utility of pregnancy-associated plasma protein A for determination of prognosis in a cohort of patients with coronary artery disease
Pregnant women with uncorrected congenital heart disease : Heart failure and mortality
Objectives
The purpose of this work was to study maternal and fetal outcomes of women with uncorrected congenital heart disease (CHD).
Background
Globally, CHD is an important cause of maternal morbidity and mortality in women reaching reproductive stage. Data are lacking from larger cohorts of women with uncorrected CHD.
Methods
The 10-year data from the European Society of Cardiology EORP ROPAC (EURObservational Research Programme Registry of Pregnancy and Cardiac disease) registry of women with uncorrected CHD were analyzed.
Results
Of 5,739 pregnancies in 53 countries, 3,295 women had CHD, 1,059 of which were uncorrected cases. Of these, 41.4% were from emerging countries. There were marked differences between the cardiac defects in uncorrected cases versus those in corrected CHD cases with primary shunt lesions (44.7% vs. 32.4%, respectively), valvular abnormalities (33.5% vs. 12.6%, respectively), and Tetralogy of Fallot and pulmonary atresia (0.8% vs. 20.3%, respectively; p < 0.001). In patients with uncorrected CHD, 6.8% were in modified World Health Organization risk class IV, approximately 10% had pulmonary hypertension (PH), and 3% were cyanotic prior to pregnancy. Maternal mortality and heart failure (HF) in the women with uncorrected CHD were 0.7% and 8.7%, respectively. Eisenmenger syndrome was associated with a very high risk of cardiac events (65.5%), maternal mortality (10.3%), and HF (48.3%). Coming from an emerging country was associated with higher pre-pregnancy signs of HF, PH, and cyanosis (p < 0.001) and worse maternal and fetal outcomes, with a 3-fold higher rate of hospital admissions for cardiac events and intrauterine growth retardation (p < 0.001).
Conclusions
Marked differences between cardiac conditions in pregnant women with uncorrected CHD and those in corrected CHD were found, with a markedly worse outcome, particularly in women with Eisenmenger syndrome and from emerging countries
Hazard Ratio and C-Index for investigated risk factors (adjusted for age and sex) in the overall cohort.
<p>The hazard ratio and the C-Index are for the comparison cardiovascular event vs. no event during follow-up. In these figures creatinine clearance is represented by eGFR.</p
Marfan syndrome versus bicuspid aortic valve disease: comparative analysis of obstetric outcome and pregnancy-associated immediate and long-Term aortic complications
Comparison of the C-Index regarding cardiovascular events vs. no events during follow-up in the overall cohort.
<p>Overall Cohort (N = 3229).</p
Cox proportional hazard regression in the stable angina cohort (N = 2652).
<p>Stable Angina (N = 2652).</p
Comparison of the C-Index regarding cardiovascular events vs. no events during follow-up in the stable angina cohort.
<p>Stable Angina Pectoris Cohort (N = 2652).</p