КОМПЛЕКСНЫЙ АНАЛИЗ ФАКТОРОВ ПРОГНОЗА У БОЛЬНЫХ ЛОКАЛИЗОВАННЫМ И МЕСТНО-РАСПРОСТРАНЕННЫМ РАКОМ ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ

Objective: to study the likelihood of tumor extracapsular invasion (EI) and lymphogenous metastasis (N+) in patients with prostate cancer(PC) after radical prostatectomy (RPE) on the basis of prognostic factors.Subjects and methods. Fifty hundred patients who had undergone RPE in 1999-2008 were enrolled in the study. The patients' age was63.2±6.2 (range 46-78) years; median prostate-specific antigen (PSA) was 11.0 ng/ml (interquartile range 7.4-19.5 ng/ml). According topreoperative findings, 418 (78.9%) and 112 (21.1%) patients were diagnosed as having advanced and locally advanced PC, respectively.According to Gleason tumor grades, the patients were distributed as follows: 2-4 scores in 94 (17.7%) patients; 5-6 scores in 266 (50.2%);7 scores in 103 (19.4%); 8-10 scores in 26 (4.9%). Planned histological studies revealed no tumor in 1.5% of cases; advanced and locallyadvanced PC was diagnosed in 54.5 and 45.5% of cases, respectively; of them N+ was in 32.9%.Results. A correlation of prognostic factors and expected outcomes was analyzed, the results of which were used to select the most importantpredictors of the extension of a tumor process (percent of positive biopsy specimens, sum of Gleason scores, PSA level, clinical process stage,presence of EI from preoperative data). Regression models were created considering the results of the logistic regression analysis. To evalu-ate efficiency, the area under the AUC-ROC curve was calculated for each model. For evaluation of the comparative effectiveness, the AUC-ROC curve was also estimated for each outcome, by applying the Partin tables.Conclusions. The developed models of predicting the presence of tumor EI and metastatic spread to the lymph nodes make it possible to havea good agreement of the predicted likelihood of an outcome and the results of a histological study. These models show a higher prognosticeffectiveness than do the Partin tables.  Комплексный анализ факторов прогноза у больных локализованным и местно-распространенным раком предстательной железы

Study of the process e+e−→ηγ→7γe^+e^-\to\eta\gamma\to 7\gamma in the energy range s\sqrt{s} = 1.07 -- 2 GeV

The $e^+e^-\to\eta\gamma$ cross section is measured in the center-of-mass energy range from 1.07 to 2.00 GeV in the decay channel $\eta\to 3\pi^0$, $\pi^0\to\gamma\gamma$. The data set with an integrated luminosity of 242 pb$^{-1}$ accumulated in the experiment with the SND detector at the VEPP-2000 $e^+e^-$ collider is analyzed.Comment: 12 pages, 3 figures

Study of the process e+e−→ωπ0→π+π−π0π0e^+e^- \to \omega\pi^0 \to \pi^+\pi^-\pi^0\pi^0 in the energy range 1.05−2.001.05-2.00 GeV with SND

The process $e^+e^- \to \omega\pi^0 \to \pi^+\pi^-\pi^0\pi^0$ is studied in the center-of-mass energy region $1.05-2.00$ GeV using data with an integral luminosity of about 35 pb$^{-1}$ collected with the SND detector at the VEPP-2000 $e^+e^-$ collider. In the energy range under study, the value of the measured Born cross section varies from 0.7 to 18 nb. The statistical uncertainty of the cross section is $2-23$%, while the systematic uncertainty is in the range of $3.0-14.2$%. The results are consistent with previous measurements but have better accuracy.Comment: 13 pages, 11 figure