Dynamics of drug sustainability Mycobacterium tuberculosis in the Belgorod region for the period of 2008-2017

To assess and compare the structure and dynamics of Mycobacterium tuberculosis drug resistance to anti-tuberculosis drugs, including multiple and broad, in the Belgorod region in newly diagnosed patients and patients with relapses of tuberculosi

The prevalence of m. tuberculosis strains of various genetic families in Belgorod region

To estimate the prevalence and association with multiple drug resistance of strains of M. tuberculosis of various genetic families in the Belgorod region, to reveal the contribution of strains of the genetic family Beijing to the epidemic process of tuberculosis; evaluate the role of strains of M. tuberculosis of various genetic families in the formation of "rural foci of tuberculosis" in the regio

Measurement of the e+e−→K+K−π+π−e^+e^- \to K^+K^-\pi^+\pi^- cross section with the CMD-3 detector at the VEPP-2000 collider

The process $e^+e^- \to K^+K^-\pi^+\pi^-$ has been studied in the center-of-mass energy range from 1500 to 2000\,MeV using a data sample of 23 pb$^{-1}$ collected with the CMD-3 detector at the VEPP-2000 $e^+e^-$ collider. Using about 24000 selected events, the $e^+e^- \to K^+K^-\pi^+\pi^-$ cross section has been measured with a systematic uncertainty decreasing from 11.7\% at 1500-1600\,MeV to 6.1\% above 1800\,MeV. A preliminary study of $K^+K^-\pi^+\pi^-$ production dynamics has been performed

КОМПЛЕКСНЫЙ АНАЛИЗ ФАКТОРОВ ПРОГНОЗА У БОЛЬНЫХ ЛОКАЛИЗОВАННЫМ И МЕСТНО-РАСПРОСТРАНЕННЫМ РАКОМ ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ

Objective: to study the likelihood of tumor extracapsular invasion (EI) and lymphogenous metastasis (N+) in patients with prostate cancer(PC) after radical prostatectomy (RPE) on the basis of prognostic factors.Subjects and methods. Fifty hundred patients who had undergone RPE in 1999-2008 were enrolled in the study. The patients' age was63.2±6.2 (range 46-78) years; median prostate-specific antigen (PSA) was 11.0 ng/ml (interquartile range 7.4-19.5 ng/ml). According topreoperative findings, 418 (78.9%) and 112 (21.1%) patients were diagnosed as having advanced and locally advanced PC, respectively.According to Gleason tumor grades, the patients were distributed as follows: 2-4 scores in 94 (17.7%) patients; 5-6 scores in 266 (50.2%);7 scores in 103 (19.4%); 8-10 scores in 26 (4.9%). Planned histological studies revealed no tumor in 1.5% of cases; advanced and locallyadvanced PC was diagnosed in 54.5 and 45.5% of cases, respectively; of them N+ was in 32.9%.Results. A correlation of prognostic factors and expected outcomes was analyzed, the results of which were used to select the most importantpredictors of the extension of a tumor process (percent of positive biopsy specimens, sum of Gleason scores, PSA level, clinical process stage,presence of EI from preoperative data). Regression models were created considering the results of the logistic regression analysis. To evalu-ate efficiency, the area under the AUC-ROC curve was calculated for each model. For evaluation of the comparative effectiveness, the AUC-ROC curve was also estimated for each outcome, by applying the Partin tables.Conclusions. The developed models of predicting the presence of tumor EI and metastatic spread to the lymph nodes make it possible to havea good agreement of the predicted likelihood of an outcome and the results of a histological study. These models show a higher prognosticeffectiveness than do the Partin tables.  Комплексный анализ факторов прогноза у больных локализованным и местно-распространенным раком предстательной железы