15 research outputs found
Photoproduction of pions and properties of baryon resonances from a Bonn-Gatchina partial wave analysis
Masses, widths and photocouplings of baryon resonances are determined in a
coupled-channel partial wave analysis of a large variety of data. The
Bonn-Gatchina partial wave formalism is extended to include a decomposition of
t- and u-exchange amplitudes into individual partial waves. The multipole
transition amplitudes for and are
given and compared to results from other analyses.Comment: 18 pages, 14 figure
P-wave excited baryons from pion- and photo-induced hyperon production
We report evidence for , , ,
, , and , and find
indications that might have a companion state at 1970\,MeV. The
controversial is not seen. The evidence is derived from a
study of data on pion- and photo-induced hyperon production, but other data are
included as well. Most of the resonances reported here were found in the
Karlsruhe-Helsinki (KH84) and the Carnegie-Mellon (CM) analyses but were
challenged recently by the Data Analysis Center at GWU. Our analysis is
constrained by the energy independent scattering amplitudes from either
KH84 or GWU. The two amplitudes from KH84 or GWU, respectively, lead to
slightly different branching ratios of contributing resonances but the
debated resonances are required in both series of fits.Comment: 22 pages, 28 figures. Some additional sets of data are adde
Ajuba is required for Rac activation and maintenance of E-cadherin adhesion
A Rac–PAK1–Ajuba feedback loop stabilizes cadherin complexes via coordination of spatiotemporal signaling with actin remodeling at cell–cell contacts
Properties of baryon resonances from a multichannel partial wave analysis
Properties of nucleon and resonances are derived from a multichannel
partial wave analysis. The statistical significance of pion and photo-induced
inelastic reactions off protons are studied in a multichannel partial-wave
analysis.Comment: 12 pages, 8 Table
Rho GTPases in collective cell migration
The family of Rho GTPases are intracellular signal transducers that link cell surface signals to multiple intracellular responses. They are best known for their role in regulating actin dynamics required for cell migration, but in addition control cell-cell adhesion, polarization, vesicle trafficking, and the cell cycle. The roles of Rho GTPases in single mesenchymal cell migration are well established and rely on Cdc42- and Rac-dependent cell protrusion of a leading edge, coupled to Rho-dependent contractility required to move the cell body forward. In cells migrating collectively, cell-cell junctions are maintained, and migrating leader cells are mechanically coupled to, and coordinate, migration with follower cells. Recent evidence suggests that Rho GTPases provide multifunctional input to collective cell polarization, cell-cell interaction, and migration. Here, we discuss the role of Rho GTPases in initiating and maintaining front-rear, apical-basal cell polarization, mechanotransduction, and cell-cell junction stability between leader and follower cells, and how these roles are integrated in collective migration. Thereby, spatiotemporal fine-tuning of Rho GTPases within the same cell and among cells in the cell group are crucial in controlling potentially conflicting, divergent cell adhesion and cytoskeletal functions to achieve supracellular coordination and mechanocoupling
Gesunde Persönlichkeitsentwicklung und Sportengagement bei salvadorianischen und deutschen Jugendlichen
Collective cell migration results from the establishment and maintenance of collective polarization, mechanocoupling, and cytoskeletal kinetics. The guidance of collective cell migration depends on a reciprocal process between cell-intrinsic multicellular organization with leader-follower cell behavior and results in mechanosensory integration of extracellular guidance cues. Important guidance mechanisms include chemotaxis, haptotaxis, durotaxis, and strain-induced mechanosensing to move cell groups along interfaces and paths of least resistance. Additional guidance mechanisms steering cell groups during specialized conditions comprise electrotaxis and passive drift. To form higher-order cell and tissue structures during morphogenesis and cancer invasion, these guidance principles act in parallel and are integrated for collective adaptation to and shaping of varying tissue environments. We review mechanochemical and electrical inputs and multiparameter signal integration underlying collective guidance, decision making, and outcome
Differential expression of p120-catenin 1 and 3 isoforms in epithelial tissues
Contains fulltext :
201031.pdf (publisher's version ) (Open Access
Burnout, resilience and work engagement among Dutch intensivists in the aftermath of the COVID-19 crisis: A nationwide survey
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232385.pdf (Publisher’s version ) (Closed access)PURPOSE: The COVID-19 crisis put a strain on intensive care resources everywhere in the world increasing the risk of burnout. Previously, the prevalence of burnout among Dutch intensivists was found to be low. Engagement and resilience among intensivists have not previously been studied quantitatively, however, both are related to burnout and provide a possible way to mitigate burnout. Our objective was to study burnout and its association with work engagement and resilience among Dutch intensivists in the aftermath of the COVID-19 crisis. METHODS: An online questionnaire was sent to all Dutch intensivists. The questionnaire consisted of questions on personal and work-related characteristics and validated questionnaires: the Maslach Burnout Inventory, the Utrecht Work Engagement Scale, and the Resilience Evaluation Scale. RESULTS: The response rate was 27.2% with 162 evaluable responses. Thirteen respondents (8.0%) were classified as having burnout, 63 (38.9%) respondents were reporting high work engagement. Burnout was found to be negatively associated with both work engagement and resilience. CONCLUSION: In the aftermath of the 2020 COVID-19 crisis, we found a raised prevalence of burnout among intensivists, however this is still low in international comparisons. Intensivists with burnout scored low on resilience and low on work engagement
P120 Catenin Isoforms Differentially Associate with Breast Cancer Invasion and Metastasis
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208685.pdf (publisher's version ) (Open Access)Tumor metastasis is the endpoint of tumor progression and depends on the ability of tumor cells to locally invade tissue, transit through the bloodstream and ultimately to colonize secondary organs at distant sites. P120 catenin (P120) has been implicated as an important regulator of metastatic dissemination because of its roles in cell-cell junctional stability, cytoskeletal dynamics, growth and survival. However, conflicting roles for P120 in different tumor models and steps of metastasis have been reported, and the understanding of P120 functions is confounded by the differential expression of P120 isoforms, which differ in N-terminal length, tissue localization and, likely, function. Here, we used in silico exon expression analyses, in vitro invasion assays and both RT-PCR and immunofluorescence of human tumors. We show that alternative exon usage favors expression of short isoform P120-3 in 1098 breast tumors and correlates with poor prognosis. P120-3 is upregulated at the invasive front of breast cancer cells migrating as collective groups in vitro. Furthermore, we demonstrate in histological sections of 54 human breast cancer patients that P120-3 expression is maintained throughout the metastatic cascade, whereas P120-1 is differentially expressed and diminished during invasion and in metastases. These data suggest specific regulation and functions of P120-3 in breast cancer invasion and metastasis