Language Contact with Crew of Rykyu\u27s Drifting Ships in the Qing Dynasty

The communication between Ryukyu・Okinawa and China has a long history. It has been said that the history has begun even at Ming Dynasty Ryukyu Dynasty were canonized by Chinese king even after Satsuma clan (now Kagoshima Prefecture)\u27s invasion in the beginning of 17 century. The tributary relations between Ryukyu and China had last for 5 centuries until Ryukyu became Okinawa Prefecture by Meiji Japanese government in 1872. The relationship between China and Ryukyu basic were tributary relations. However, the main transportation mean in Ryukyu were by ship，and lots of ship encountered typhoon, lost control of their ship，and finally were drifted to China continent. You can refer to these historical documentation in the book「Selected documentation of China-Ryukyurelations in Qing Dynasty」which was public by China First Historical Archives. Lots of ship-drift cases are written in this book from Qianlong era to Guangxu era of Qing Dynasty. Various forms of transportation can be found form those cases. This paper will not focus on tributary ships from Ryukyu, but on the part of rescue and aid from Qing government to those who were drifted from Ryukyu．文部科学省グローバルCOEプログラム 関西大学文化交渉学教育研究拠点東アジアの歴史と動

Effects of a hydrogen sulfide donor on spontaneous contractile activity of rat stomach and jejunum

We studied the effect of sodium hydrosulfite (NaHS), a donor of hydrogen sulfide (H2S), on spontaneous contractive activity of isolated preparations of rat stomach and jejunum under isometric conditions. NaHS in concentrations of 10-200 μM reduced the amplitude, tonic tension, and frequency of contractions of the preparations. Blockade of K+ channels with a non-specific antagonist tetraethylammonium (10 mM) increased contraction amplitude in the stomach strip and jejunum segment. The effects of NaHS on all parameters of contractile activity of the stomach and jejunum were fully preserved against the background of tetraethylammonium application. These data suggest that H2S in physiologically relevant concentrations inhibited spontaneous contractile activity of smooth muscle cells in rat stomach and jejunum by reducing the amplitude and frequency of contractions and decreased tonic tension without affecting the function of voltage- and calcium-dependent K+ channels. © 2014 Springer Science+Business Media

Effect of I<inf>Ca,L</inf> blockade on adrenergic stimulation in developing heart

© 2016 Springer Science+Business Media New York.The effect of verapamil-induced blockade of L-type calcium ionic currents (ICa,L) on the action of non-selective adrenergic cardiac stimulation by norepinephrine was examined during different periods of early postnatal ontogeny. In 1-week-old rats, intravenous norepinephrine induced a short-term tachycardia both with and without preliminary injected verapamil. In 3-week-old rats, norepinephrine alone produced no chronotropic effect; in contrast, it induced a biphasic tachycardia in verapamil-treated rats. In 6- and 20-month-old rats, norepinephrine induced a short-term tachycardia, which could be prevented by verapamil. The age-related peculiarities of chronotropic action of non-selective adrenergic stimulation are indicative of the role of L-type calcium ionic channels in the development of sympathetic control over the heart

Effect of NO Synthase Blockade on NO Production in Rat Heart under Conditions of Hypokinesia

© 2014, Springer Science+Business Media New York. Electron paramagnetic (EPR) spectroscopy study showed that 90-day hypokinesia in rats is accompanied by an increase in NO production in the heart. A nonselective NO synthase inhibitor L-NAME decreased the content of NO in the heart atria and ventricles of hypokinetic rats by 67-70%. A selective inhibitor of inducible NO synthase, aminoguanidine, also decreased the level of NO in the heart atria and ventricles of hypokinetic rats by 60-65%. Our results indicate that the increase in NO production during hypokinesia is associated with activation of NO synthases

Effect of NO Synthase Blockade on Myocardial Contractility of Hypokinetic Rats during Stimulation of β-Adrenoreceptors

© 2016, Springer Science+Business Media New York.Stimulation of β-adrenoreceptors with low (10–8 and 10–7 M) or high (10–6 M) doses of isoproterenol in hypokinetic rats treated with L-NAME (a non-selective blocker of NO synthases) decreased or increased myocardial contractility, respectively. In control rats, all examined doses of isoproterenol used under blockade of NO synthases inhibited myocardial contractility

Asymmetrical effects of vagus nerves on functional parameters of rat heart in postnatal ontogeny

Significant age-related peculiarities in the dynamics of stroke volume and parameters of variational pulsogram are revealed in bilaterally vagotomized in rats. Asymmetry in vagal influences on cardiac function appear during puberty. Right-sided vagotomy predominantly affects variability of the cardiac rhythm, while left-sided vagotomy mostly affects the force of heart contractions

Peculiarities of synaptic vesicle recycling in frog and mouse motor nerve terminals

Using electrophysiology and fluorescence microscopy with dye FM 1-43, a comparative study of peculiarities of neurotransmitter secretion, synaptic vesicle exo-endocytosis and recycling has been carried out in nerve terminals (NT) of the skin-sternal muscle of the frog Rana ridibunda and of the white mouse diaphragm muscle during a long-term high-frequency stimulation (20 imp/s). The obtained data have allowed identifying three synaptic vesicle pools and two recycling ways in the motor NT. In the frog NT, the long-term high-frequency stimulation induced consecutive expenditure of the pool ready to release, the mobilizational, and reserve vesicle pools. The exocytosis rate exceeded markedly the endocytosis rate; the slow synaptic vesicle recycling with replenishment of the reserve pool was predominant. In the mouse NT, only the vesicles of the ready to release and the mobilizational pools, which are replenished predominantly by fast recycling, were exocytosed. The exo- and endocytosis occurred practically in parallel, while vesicles of the reserve pool did not participate in the neurotransmitter secretion. It is suggested that evolution of the motor NT from the poikilothermal to homoiothermal animals went by the way of a decrease of the vesicle pool size, the more economic expenditure and the more effective reuse of synaptic vesicles owing to the high rates of endocytosis and recycling. These peculiarities can provide in NT of homoiothermal animals a long maintenance of neurotransmitter secretion at the steady and sufficiently high level to preserve reliability of synaptic transmission in the process of the high-frequency activity. © 2008 Pleiades Publishing, Ltd

Peculiar effects of muscarinic M1, M2, and M3 receptor blockers on cardiac chronotropic function in neonatal rats.

The effects of muscarinic M(1), M(2), and M(3) cholinergic receptor blockade on the regulation of chronotropic function of the heart were studied in vivo in 7-day-old rat pups. Intravenous injection of M(2) receptor blocker gallamine produced no changes in cardiac chronotropy. In contrast, M(1) receptor blocker pirenzepine and M(3) receptor blocker 4DAMP provoked bradycardia. These data attest to the involvement of M(1) and especially M(3) cholinergic receptors in the regulation of cardiac chronotropy in rat pups, which confirms the view on pronounced species-specific and age-related peculiarities in the heart control mechanisms

Blockade of hyperpolarizing currents produces a dose-dependent effect on heart rate

Intravenous injection of ZD 7288, a new specific hyperpolarizing current blocker, dose-dependently reduces heart rate in adult rats. The autonomic nervous system modulates changes in heart rate caused by hyperpolarizing currents

Blockade of different subtypes of α1-adrenoceptors produces opposite effect on heart chronotropy in newborn rats

We compared the effects of blockade of α1A-, α1-, and α1D-subtypes of α1- adrenoceptors on the cardiac rhythm in newborn rats. Different responses of the heart were observed after blockade of several subtypes of α1- adrenoceptors. Administration of WB 4101, a selective blocker of α1A-adrenoceptors, increased heart rate, while blockade of α1AD-adrenoceptors with BMY 7378 decelerated of heart rhythm. Blockade of α1-adrenoceptors with chloroethylclonidine produced no significant effects on heart chronotropy. © 2012 Springer Science+Business Media New York