Morphometry of the adult human dry hip bone in Kashmiri population

Background: The distinctive morphology of the human hip bone makes it of interest from anatomical, anthropological and forensic point of view. Thus, by using visual criteria, metric techniques and discriminant function analysis we can estimate the age, sex and race of an individual. Objective was to do the morphometry of 60 dry human hip bones in Kashmiri population in order to evaluate the various parameters of the hip bone.Methods: The study was done on 60 randomly collected Kashmiri adult unpaired hip bones of unknown sex to analyse and evaluate the weight, length, width and the Coxal index of hip bone. All the hip bones selected were dry, complete and showed normal anatomical features. Specimens showing osteoarthritic changes, evidence of any previous trauma or skeletal disorders was excluded from the study.Results: The raw data obtained was statistically analysed. Range, mean, standard deviation and standard error of mean were determined for each parameter. All values were compared with series of other workers to draw the conclusions.Conclusions: From this study, it was concluded that right hip bone has larger parameters and greater strength of skeletal elements. The difference seen between the values of present study and that of other workers could be explained on the basis of ethnic and racial variations.

Improvement of semen quality after treatment with folic acid and zinc in subfertile men in a tertiary hospital

Background: The 50% of all male infertility is idiopathic, and there is currently no recognized treatment. The effectiveness of a nonprescription nutraceutical comprising eight nutrients on sperm quality in males with idiopathic infertility was studied. The aim of the study was to evaluate improvement of semen quality after treatment with folic acid and zinc in subfertile men. Methods: This prospective observational study was carried out in the infertility unit, department of obstetrics and gynaecology, Bangabandhu Sheikh Mujib medical university (BSMMU), Dhaka, Bangladesh from January 2018 to June 2020. Approval from local ethics committee was obtained for this study.Results: One hundred and twenty-five male subfertile patients were included in this study. Most men, 99 (79.2%) belong to more than 30 years, followed by 26 (20.8%) less than 30 years, range was 25 to 50 years. Mean ± SD age was 35.3±5.1 years. Rapid linear (RL) before treatment were 16.06±14.46 (mean ± SD) and after treatment were 22.82±13.40 (mean ± SD). Slow linear (SL) before treatment were 17.56±12.06 (mean ± SD) and after treatment were 19.75±9.25 (mean ± SD). Non progressive (NP) before treatment were 10.82±8.95 (mean ± SD) and after treatment were 10.12±7.34 (mean ± SD). Morphology of the sperm before treatment were 19.43±15.48 (mean ± SD) and after treatment were 30.18±19.12 (mean ± SD).Conclusions:  Our research findings fully correspond to the above research results, so it can be said that treatment of subfertile men with micronutrients like folic acid and zinc sulfate causes increase of semen quality and thus plays a key role in treatment of male subfertility

Enhanced Production of Invertase from Thermoltolerant Yeast Through Black Strap Molasses a Waste Prodcut of Sugar Industry

Abstract: The current study shows an improved mutant of S. cerevisiae selected for the production of Fructofuranosidase (Ffase) from different substrates of industrial waste products in a semi commercial scale digitally controlled bioreactor. Fermentation parameters, such as carbon sources and their concentrations (12-15%), nitrogen sources (0.2%), air flow rate (0.2 vvm), agitational intensity (300 rpm), additives (NaF) were optimized.This gamma ray-induced mutation has given a stable and viable mutant for hyper-production of invertase Ffase.The productivity is >2.0-fold improved over the parental strain on an industrial waste molasses-based medium for extracellular and intracellular Ffase production using semi commercial production conditions. This enhancement occurred due to increase in gene copy number and improvement in gene expression or both or improvement in transport system of the cells. The mechanism underlying this hyper-secretion is of paramount significance and needs further study. The mutant of S. cerevisiae has obvious advantage of hyper production of Ffase and may serve as a starting strain for further genetic improvement. It is concluded that this organism may be exploited for bulk production of invertase using molasses an inexpensive and abundant

Substantial and sustained reduction in under-5 mortality, diarrhea, and pneumonia in Oshikhandass, Pakistan : Evidence from two longitudinal cohort studies 15 years apart

Funding Information: Study 1 was funded through the Applied Diarrheal Disease Research Program at Harvard Institute for International Development with a grant from USAID (Project 936–5952, Cooperative Agreement # DPE-5952-A-00-5073-00), and the Aga Khan Health Service, Northern Areas and Chitral, Pakistan. Study 2 was funded by the Pakistan US S&T Cooperative Agreement between the Pakistan Higher Education Commission (HEC) (No.4–421/PAK-US/HEC/2010/955, grant to the Karakoram International University) and US National Academies of Science (Grant Number PGA-P211012 from NAS to the Fogarty International Center). The funding bodies had no role in the design of the study, data collection, analysis, interpretation, or writing of the manuscript. Publisher Copyright: © 2020 The Author(s).Peer reviewedPublisher PD

Audit on incidents and knowledge of nurses regarding chemotherapy extravasations at day care oncology of a tertiary care hospital in Karachi, Pakistan

Purpose: Extravasations of cytotoxic agents after intravenous administration results in serious damage to the tissues leading to local injury and tissue necrosis. Worldwide incidence of extravasation ranges from 0.1% – 6%. Patient education, early identification and management can reduce morbidity associated with chemotherapy extravasation.Method: This audit was conducted at day care oncology of Aga Khan University Hospital to assess the knowledge of nursing staff regarding identification, management and teaching to the patients about of chemotherapy extravasations before and after teaching (intervention) sessions. These sessions were conducted monthly, for a year (July 2016 till June 2017). We also recorded incidents of extravasation reported before (February till June 2016) and after (July till November 2017) intervention.Results: A total of twelve nurses were audited before and after the intervention. Their mean age was 36.08 years ±3.35 (range 32-42 years). They had median 5 years’ (range 1-13 years) experience at Daycare Oncology. Overall, 63% and 96% had demonstrated and answered the steps of identification and management correctly in audit before and after intervention respectively (P\u3c0.001). Incidence of chemotherapy extravasation was 0.128% (7/5461) and 0.054% (3/5546) before and after intervention. In total, vinorelbine was the most common drug associated with such incidence (50%). Most had grade II reaction (50%) and history of chemotherapy (70%) was the most common risk factor.Conclusion: Our hospital based incidence of chemotherapy extravasation is comparable to international data. This may be reduced further by improving knowledge of nurses regarding prevention, prompt identification, management and education of patients

Raw Materials, Technology, Healthcare Applications, Patent Repository and Clinical Trials on 4D Printing Technology: An Updated Review

After the successful commercial exploitation of 3D printing technology, the advanced version of additive manufacturing, i.e., 4D printing, has been a new buzz in the technology-driven industries since 2013. It is a judicious combination of 3D printing technologies and smart materials (stimuli responsive), where time is the fourth dimension. Materials such as liquid crystal elastomer (LCE), shape memory polymers, alloys and composites exhibiting properties such as self–assembling and self-healing are used in the development/manufacturing of these products, which respond to external stimuli such as solvent, temperature, light, etc. The technologies being used are direct ink writing (DIW), fused filament fabrication (FFF), etc. It offers several advantages over 3D printing and has been exploited in different sectors such as healthcare, textiles, etc. Some remarkable applications of 4D printing technology in healthcare are self-adjusting stents, artificial muscle and drug delivery applications. Potential of applications call for further research into more responsive materials and technologies in this field. The given review is an attempt to collate all the information pertaining to techniques employed, raw materials, applications, clinical trials, recent patents and publications specific to healthcare products. The technology has also been evaluated in terms of regulatory perspectives. The data garnered is expected to make a strong contribution to the field of technology for human welfare and healthcare

DABCO–PEG ionic liquid-based synthesis of acridine analogous and its inhibitory activity on alkaline phosphatase

<p>In world, many people struggle with viral, parasitic, bacterial, cancer, and other diseases. Therefore, numerous chemists seek to develop less toxic, more selective, and effective medicines. Most therapeutic medicines are based on inhibition of specific enzymes. Acridines are interesting heterocyclic structures that are much sought after targets attributed to their wide biological activities and feature to display potent enzymes inhibitory effects. Their approach of action is owing to DNA interaction and subsequent effects on the biological functions linked to DNA and associated enzymes. In this regards, we synthesized acridine analogous through 1,4-diazabicyclo[2.2.2]octane (DABCO)–polyethylene glycol-400 (PEG-400) mediated ionic liquid approach. DABCO–PEG-400-mediated IL was prepared through the DABCO alkylation using 1-bromopentane followed by mixing with PEG-400. The synthesized analogous were investigated as inhibitors of alkaline phosphatase, which is a nonspecific phosphomonoester hydrolase that catalyzes the hydrolysis of broad spectrum of organic monophosphates. Analogue viz. 3,3,6,6-tetramethyl-9-(4-nitrophenyl)-2,3,4,5,6,7,9,10-octahydroacridine-1,8-dione was found to be potent alkaline phosphatase inhibitor.</p