33 research outputs found

    Influence of contouring the lithium metal/solid electrolyte interface on the critical current for dendrites

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    Contouring or structuring of the lithium/ceramic electrolyte interface and therefore increasing its surface area has been considered as a possible strategy to increase the charging current in solid-state batteries without lithium dendrite formation and short-circuit. By coupling together lithium deposition kinetics and the me chanics of lithium creep within calculations of the current distribution at the interface, and leveraging a model for lithium dendrite growth, we show that efforts to avoid dendrites on charging by increasing the interfacial surface area come with significant limitations associated with the topography of rough surfaces. These limitations are sufficiently severe such that it is very unlikely contouring could increase charging currents while avoiding dendrites and short-circuit to the levels required. For example, we show a sinusoidal surface topography can only raise the charging current before dendrites occur by approx. 50% over a flat interface

    Influence of contouring the lithium metal/solid electrolyte interface on the critical current for dendrites

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    Contouring or structuring of the lithium/ceramic electrolyte interface and therefore increasing its surface area has been considered as a possible strategy to increase the charging current in solid-state batteries without lithium dendrite formation and short-circuit. By coupling together lithium deposition kinetics and the me chanics of lithium creep within calculations of the current distribution at the interface, and leveraging a model for lithium dendrite growth, we show that efforts to avoid dendrites on charging by increasing the interfacial surface area come with significant limitations associated with the topography of rough surfaces. These limitations are sufficiently severe such that it is very unlikely contouring could increase charging currents while avoiding dendrites and short-circuit to the levels required. For example, we show a sinusoidal surface topography can only raise the charging current before dendrites occur by approx. 50% over a flat interface

    A Single-Cell Atlas of Bovine Skeletal Muscle Reveals Mechanisms Regulating Intramuscular Adipogenesis and Fibrogenesis

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    Background Intramuscular fat (IMF) and intramuscular connective tissue (IMC) are often seen in human myopathies and are central to beef quality. The mechanisms regulating their accumulation remain poorly understood. Here, we explored the possibility of using beef cattle as a novel model for mechanistic studies of intramuscular adipogenesis and fibrogenesis. Methods Skeletal muscle single-cell RNAseq was performed on three cattle breeds, including Wagyu (high IMF), Brahman (abundant IMC but scarce IMF), and Wagyu/Brahman cross. Sophisticated bioinformatics analyses, including clustering analysis, gene set enrichment analyses, gene regulatory network construction, RNA velocity, pseudotime analysis, and cell-cell communication analysis, were performed to elucidate heterogeneities and differentiation processes of individual cell types and differences between cattle breeds. Experiments were conducted to validate the function and specificity of identified key regulatory and marker genes. Integrated analysis with multiple published human and non-human primate datasets was performed to identify common mechanisms. Results A total of 32 708 cells and 21 clusters were identified, including fibro/adipogenic progenitor (FAP) and other resident and infiltrating cell types. We identified an endomysial adipogenic FAP subpopulation enriched for COL4A1 and CFD (log2FC = 3.19 and 1.92, respectively; P \u3c 0.0001) and a perimysial fibrogenic FAP subpopulation enriched for COL1A1 and POSTN (log2FC = 1.83 and 0.87, respectively; P \u3c 0.0001), both of which were likely derived from an unspecified subpopulation. Further analysis revealed more progressed adipogenic programming of Wagyu FAPs and more advanced fibrogenic programming of Brahman FAPs. Mechanistically, NAB2 drives CFD expression, which in turn promotes adipogenesis. CFD expression in FAPs of young cattle before the onset of intramuscular adipogenesis was predictive of IMF contents in adulthood (R2 = 0.885, P \u3c 0.01). Similar adipogenic and fibrogenic FAPs were identified in humans and monkeys. In aged humans with metabolic syndrome and progressed Duchenne muscular dystrophy (DMD) patients, increased CFD expression was observed (P \u3c 0.05 and P \u3c 0.0001, respectively), which was positively correlated with adipogenic marker expression, including ADIPOQ (R2 = 0.303, P \u3c 0.01; and R2 = 0.348, P \u3c 0.01, respectively). The specificity of Postn/POSTN as a fibrogenic FAP marker was validated using a lineage-tracing mouse line. POSTN expression was elevated in Brahman FAPs (P \u3c 0.0001) and DMD patients (P \u3c 0.01) but not in aged humans. Strong interactions between vascular cells and FAPs were also identified. Conclusions Our study demonstrates the feasibility of beef cattle as a model for studying IMF and IMC. We illustrate the FAP programming during intramuscular adipogenesis and fibrogenesis and reveal the reliability of CFD as a predictor and biomarker of IMF accumulation in cattle and humans

    Non-Standard Errors

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    In statistics, samples are drawn from a population in a data-generating process (DGP). Standard errors measure the uncertainty in estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence-generating process (EGP). We claim that EGP variation across researchers adds uncertainty: Non-standard errors (NSEs). We study NSEs by letting 164 teams test the same hypotheses on the same data. NSEs turn out to be sizable, but smaller for better reproducible or higher rated research. Adding peer-review stages reduces NSEs. We further find that this type of uncertainty is underestimated by participants

    Supplementary document for Spectro-temporal evolution of mode-locked lasing in fiber frequency-shifted feedback laser - 6006468.pdf

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    A detailed description of the principle of acquiring laser spectra (for the single and double-pulse states) using the double-beam heterodyne method and the method of demodulation of the relative phases of the double pulses are presented

    Numerical Analysis on the Hydrodynamic Performance of an Artificially Ventilated Surface-Piercing Propeller

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    When operated under large water immersion, surface piercing propellers are prone to be in heavy load conditions. To improve the hydrodynamic performance of the surface piercing propellers, engineers usually artificially ventilate the blades by equipping a vent pipe in front of the propeller disc. In this paper, the influence of artificial ventilation on the hydrodynamic performance of surface piercing propellers under full immersion conditions was investigated using the Computational Fluid Dynamics (CFD) method. The numerical results suggest that the effect of artificial ventilation on the pressure distribution on the blades decreases along the radial direction. And at low advancing speed, the thrust, torque as well as the efficiency of the propeller are smaller than those without ventilation. However, with the increase of the advancing speed, the efficiency of the propeller rapidly increases and can be greater than the without-ventilation case. The numerical results demonstrates the effectiveness of the artificial ventilation approach for improving the hydrodynamic performance of the surface piercing propellers for high speed planning crafts

    Numerical Analysis on the Effect of Artificial Ventilated Pipe Diameter on Hydrodynamic Performance of a Surface-Piercing Propeller

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    Under the condition of large water immersion, surface-piercing propellers are inclined to be heavy loaded. In order to improve the hydrodynamic performance of the surface-piercing propeller, the installation of a vent pipe in front of a propeller disc is more widely used in the propulsion device of high speed planning crafts. Based on computational fluid dynamics (CFD) method, this paper studied the influence of diverse vent pipe diameters on hydrodynamic performance of the surface-piercing propeller under full water immersion conditions. The numerical results show that, with the increase of vent pipe diameters, the thrust and torque of the surface-piercing propeller decrease after ventilation, and the efficiency of the propeller increases rapidly; the low pressure area near the back root of the blade becomes smaller and smaller gradually; and the peak of periodic vibration of thrust and torque can be effectively reduced. The numerical results demonstrate that the installation of artificial vent pipe effectively improves the hydrodynamic performance of surface piercing propeller in the field of high speed crafts, and the increase of artificial vent pipe diameter plays an active role in the propulsion efficiency of the surface-piercing propeller

    A Study on the Motion of Partial Air Cushion Support Catamaran in Regular Head Waves

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    In this paper, the motion of partial air cushion support catamaran (PACSCAT) sailing in regular waves was firstly investigated by the experimental method. The monitored histories of heave, pitch, midship acceleration, and air cushion pressure in towing tests are performed to analyze the influence of air cushion on the periodicity feature of hull body motion. Subsequently, using the finite volume method (FVM)-based CFD software Star-ccm, numerical simulations are carried out for the PACSCAT model with a simplification of the air cushion system. The detailed flow information of wave evolution, pressure, and velocity distribution is investigated. The calculated oscillation characteristics of different motion parameters are compared with those from experiment and show good agreement. The numerical method also has good capacity in the prediction of amplitude response of heave and midship acceleration; however, large error is found when calculating resistance and amplitude response of pitch

    EPI Light Field Depth Estimation Based on a Directional Relationship Model and Multiviewpoint Attention Mechanism

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    Light field (LF) image depth estimation is a critical technique for LF-related applications such as 3D reconstruction, target detection, and tracking. The refocusing property of LF images provide rich information for depth estimations; however, it is still challenging in cases of occlusion regions, edge regions, noise interference, etc. The epipolar plane image (EPI) of LF can effectively deal with the depth estimation because of its characteristics of multidirectionality and pixel consistency—in which the LF depth estimations are converted to calculate the EPI slope. This paper proposed an EPI LF depth estimation algorithm based on a directional relationship model and attention mechanism. Unlike the subaperture LF depth estimation method, the proposed method takes EPIs as input images. Specifically, a directional relationship model was used to extract direction features of the horizontal and vertical EPIs, respectively. Then, a multiviewpoint attention mechanism combining channel attention and spatial attention is used to give more weight to the EPI slope information. Subsequently, multiple residual modules are used to eliminate the redundant features that interfere with the EPI slope information—in which a small stride convolution operation is used to avoid losing key EPI slope information. The experimental results revealed that the proposed algorithm outperformed the compared algorithms in terms of accuracy
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