8 research outputs found
Efficiency of application original preservatives for conservation leukocytes at -40 Β°C
When frozen leukocytes exposed to harmful factors of the complex, due to their complex cellular structure and high metabolism. Cryopreservatives allow to avoid damages, but most of which are toxic. The aim of the present was to compare the efficacy of application of two non-toxic solutions for conservation of leukocytes at -40Β°Π‘ for 1 day. It was show that solution containing cryoprotector mixed action (a derivative of urea) and antihypoxant (sodium fumarate) is most effective in preserving the functional activity of leukocytes
The foraminiferal zonal scale of the DevonianβCarboniferous boundary beds in Russia and Western Kazakhstan and its correlation with ammonoid and conodont scales
This paper reviews the foraminiferal biostratigraphy of the DevonianβCarboniferous (DβC) boundary beds in Russia and Western Kazakhstan. The regional records of the zonal successions of Russia are summarised from sections and boreholes of the Volga-Urals Subregion of the East European Platform (Syzran no. 401 Borehole, Melekesskaya no.1 Borehole); Timan-Pechora Province of the East European Platform (Kamenka Section); South Urals (Sikaza, Zigan, Ryauzyak and Dzerzhinka sections); Middle Urals (Pershino Section); and West Siberia, Vagai-Ishim Basin (Borehole no. 1 Kurgan-Uspenskaya), and the zonal successions of Western Kazakhstan are summarised from the Mugodzhary Mountains. Three foraminiferal biozones can be defined in the interval comprising the latest Devonian and earliest Carboniferous: Quasiendothyra kobeitusana Zone, the Tournayellina pseudobeata β remnant Quasiendothyra Zone, and the Earlandia minima Zone. The DβC boundary interval is situated within the Tournayellina pseudobeataβremnant Quasiendothyra Zone. A correlation with the ammonoid and conodont zonations is proposed, which is useful for correlating deep-water and shallow-water successions
CLINICAL DIAGNOSIS SCALE FOR NEUROENDOCRINE CELL HYPERPLASIA IN INFANTS: INFORMATIVENESS AND DIFFERENTIAL DIAGNOSTIC SIGNIFICANCE
Neuroendocrine cell hyperplasia of infancy (NEHI) is an interstitial lung disease of unknown etiology that develops in the first year of life and manifests itself as persistent tachypnea syndrome. The aim of the study was to determine the diagnostic value of the clinical scale for the diagnosis of NEHI in comparison with computed tomography (CT) data of the chest organs and for differential diagnosis with acute bronchiolitis (AB)/community-acquired pneumonia (CAP). Materials and methods of research: a multicenter case-control study of children aged 21 days of life to 12 months was carried out: β 83 children with NEHI and 83 infants with AB or CAP. To determine the sensitivity and specificity of this scale for differential diagnosis with AB/CAP, the results of the assessment according to the proposed scale were compared in patients with NEHI (study group) and patients with AB/CAP (control group) on the day of treatment and after 3 weeks. Results: the sensitivity of the clinical scale for the diagnosis of NEHI when compared with the CT data of the chest organs was 85.5%. In the differential diagnosis of NEHI with AB/CAP on the day of treatment, the sensitivity of the clinical scale for the diagnosis of NEHI was 85.5%, the specificity was 80.7%; when re-evaluated after 3 weeks, the accuracy of the scale increased from 83.1% to 91.6%, the specificity β from 80.7% to 97.6%. Diagnosis on a scale after 3 weeks reduced the possibility of overdiagnosis of NEHI from 19.3% to 2.4%. Conclusions: the clinical scale for the diagnosis of NEHI has a high diagnostic value in comparison with the results of CT scan of the chest organs and for differential diagnosis with AB/CAP, especially when re-evaluating. Β© 2022, Pediatria Ltd. All rights reserved
ΠΠΎΠ·ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΡΡΡΠΊΡΡΡΠ° ΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΈΠ½ΡΠ΅ΡΡΡΠΈΡΠΈΠ°Π»ΡΠ½ΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Π»Π΅Π³ΠΊΠΈΡ Ρ Π΄Π΅ΡΠ΅ΠΉ ΠΏΠ΅ΡΠ²ΡΡ 2 Π»Π΅Ρ ΠΆΠΈΠ·Π½ΠΈ: ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΌΠ½ΠΎΠ³ΠΎΡΠ΅Π½ΡΡΠΎΠ²ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ
The article presents data about study included 76 children of the first two years of life with interstitial lung diseases (ILD). According to symptoms of chILD-syndrome, all patients had respiratory signs and interstitial changes on X-ray. 93.4% of patients had respiratory symptoms, hypoxemia was revealed in 68.4% of patients by pulsoximetry. The presence of those symptoms allowed to establish chILD-syndrome in all patients, and, on the basis of clinical and laboratory-instrumental studies, nosological form was refined. Children of our study have forms of IlD such as congenital alveolar-capillary dysplasia (1.3%), pulmonary hypoplasia (17%), Wilson-Mikity syndrome (21.1%), subpleural cysts in patients with Down syndrome (6.6%), neuroendocrine cell hyperplasia of infancy (23.7%), congenital deficiency of surfactant protein B (1.3%), brain-lung-thyroid syndrome (2.6%), bronchiolitis obliterans with organizing pneumonia (10.5%), disorders related to systemic disease processes (Langerhans cell histiocytosis - 14.6%, Niemann-Pick disease - 1.3%). The features of clinical picture, data of laboratory-instrumental methods of investigation, severity of the disease's course, prognosis, predictors of the death outcome in patients with these rare diseases, have been analyzed in all patients including preterm infants.Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΎΠ± ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ, Π² ΠΊΠΎΡΠΎΡΠΎΠ΅ Π²ΠΎΡΠ»ΠΈ 76 Π΄Π΅ΡΠ΅ΠΉ ΠΏΠ΅ΡΠ²ΡΡ
2 Π»Π΅Ρ ΠΆΠΈΠ·Π½ΠΈ Ρ ΠΈΠ½ΡΠ΅ΡΡΡΠΈΡΠΈΠ°Π»ΡΠ½ΡΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ Π»Π΅Π³ΠΊΠΈΡ
(ΠΠΠ). ΠΡΠΈ ΠΎΡΠ΅Π½ΠΊΠ΅ ΡΠΈΠΌΠΏΡΠΎΠΌΠΎΠ², Π²Ρ
ΠΎΠ΄ΡΡΠΈΡ
Π² Π΄Π΅ΡΡΠΊΠΈΠΉ ΠΠΠ-ΡΠΈΠ½Π΄ΡΠΎΠΌ, Ρ Π²ΡΠ΅Ρ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΈΡΡ ΠΎΠ±ΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΈΠΌΠΏΡΠΎΠΌΡ ΠΈ ΠΈΠ½ΡΠ΅ΡΡΡΠΈΡΠΈΠ°Π»ΡΠ½ΡΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΏΠΎ Π΄Π°Π½Π½ΡΠΌ ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ. Π£ 93,4% ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΎΡΠΌΠ΅ΡΠ°Π»ΠΈΡΡ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΡΠ΅ ΡΠΈΠΌΠΏΡΠΎΠΌΡ, Ρ 68,4% ΠΏΠΎ Π΄Π°Π½Π½ΡΠΌ ΠΏΡΠ»ΡΡΠΎΠΊΡΠΈΠΌΠ΅ΡΡΠΈΠΈ Π±ΡΠ»Π° Π²ΡΡΠ²Π»Π΅Π½Π° Π³ΠΈΠΏΠΎΠΊΡΠ΅ΠΌΠΈΡ, ΡΡΠΎ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΎ ΡΡΡΠ°Π½ΠΎΠ²ΠΈΡΡ Π΄Π΅ΡΡΠΊΠΈΠΉ ΠΠΠ-ΡΠΈΠ½Π΄ΡΠΎΠΌ Ρ Π²ΡΠ΅Ρ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², Π° Π½Π° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΡ
ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΠΎ-ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π±ΡΠ»Π° ΡΡΠΎΡΠ½Π΅Π½Π° Π½ΠΎΠ·ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠΎΡΠΌΠ°. ΠΠΠ Ρ Π½Π°Π±Π»ΡΠ΄Π°Π²ΡΠΈΡ
ΡΡ Π΄Π΅ΡΠ΅ΠΉ Π²ΠΊΠ»ΡΡΠ°Π»ΠΈ Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΡΡ Π°Π»ΡΠ²Π΅ΠΎΠ»ΡΡΠ½ΠΎ-ΠΊΠ°ΠΏΠΈΠ»Π»ΡΡΠ½ΡΡ Π΄ΠΈΡΠΏΠ»Π°Π·ΠΈΡ (1,3%), Π»Π΅Π³ΠΎΡΠ½ΡΡ Π³ΠΈΠΏΠΎΠΏΠ»Π°Π·ΠΈΡ (17%), ΡΠΈΠ½Π΄ΡΠΎΠΌ ΠΠΈΠ»ΡΡΠΎΠ½Π°-ΠΠΈΠΊΠΈΡΠΈ (21,1%), ΡΡΠ±ΠΏΠ»Π΅Π²ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΊΠΈΡΡΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠΌ ΠΠ°ΡΠ½Π° (6,6%), Π½Π΅ΠΉΡΠΎΡΠ½Π΄ΠΎΠΊΡΠΈΠ½Π½ΡΡ Π³ΠΈΠΏΠ΅ΡΠΏΠ»Π°Π·ΠΈΡ ΠΌΠ»Π°Π΄Π΅Π½ΡΠ΅Π² (23,7%), Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΡΠΉ Π΄Π΅ΡΠΈΡΠΈΡ ΡΡΡΡΠ°ΠΊΡΠ°Π½ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΠΈΠ½Π° Π (1,3%), ΡΠΈΠ½Π΄ΡΠΎΠΌ Β«ΠΌΠΎΠ·Π³-Π»Π΅Π³ΠΊΠΈΠ΅-ΡΠΈΡΠΎΠ²ΠΈΠ΄Π½Π°Ρ ΠΆΠ΅Π»Π΅Π·Π°Β» (2,6%), ΠΎΠ±Π»ΠΈΡΠ΅ΡΠΈΡΡΡΡΠΈΠΉ Π±ΡΠΎΠ½Ρ
ΠΈΠΎΠ»ΠΈΡ Ρ ΠΎΡΠ³Π°Π½ΠΈΠ·ΡΡΡΠ΅ΠΉΡΡ ΠΏΠ½Π΅Π²ΠΌΠΎΠ½ΠΈΠ΅ΠΉ (10,5%), ΠΈΠ½ΡΠ΅ΡΡΡΠΈΡΠΈΠ°Π»ΡΠ½ΡΠ΅ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ Π»Π΅Π³ΠΊΠΈΡ
ΠΏΡΠΈ ΡΠΈΡΡΠ΅ΠΌΠ½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΡ
(Π³ΠΈΡΡΠΈΠΎΡΠΈΡΠΎΠ· ΠΈΠ· ΠΊΠ»Π΅ΡΠΎΠΊ ΠΠ°Π½Π³Π΅ΡΠ³Π°Π½ΡΠ° - 14,6%, Π±ΠΎΠ»Π΅Π·Π½Ρ ΠΠΈΠΌΠ°Π½Π½Π°-ΠΠΈΠΊΠ° - 1,3%). ΠΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½Ρ, Π΄Π°Π½Π½ΡΠ΅ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΠΎΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ, ΡΡΠΆΠ΅ΡΡΡ ΡΠ΅ΡΠ΅Π½ΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, ΠΏΡΠΎΠ³Π½ΠΎΠ·, Π²ΡΡΠ²Π»Π΅Π½Ρ ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΎΡΡ Π»Π΅ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΡΡ
ΠΎΠ΄Π° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π΄Π°Π½Π½ΡΠΌΠΈ ΡΠ΅Π΄ΠΊΠΈΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ Ρ Π½Π΅Π΄ΠΎΠ½ΠΎΡΠ΅Π½Π½ΡΡ
Π΄Π΅ΡΠ΅ΠΉ
ΠΠΎΠ·ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΡΡΡΠΊΡΡΡΠ° ΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΈΠ½ΡΠ΅ΡΡΡΠΈΡΠΈΠ°Π»ΡΠ½ΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Π»Π΅Π³ΠΊΠΈΡ Ρ Π΄Π΅ΡΠ΅ΠΉ ΠΏΠ΅ΡΠ²ΡΡ 2 Π»Π΅Ρ ΠΆΠΈΠ·Π½ΠΈ: ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΌΠ½ΠΎΠ³ΠΎΡΠ΅Π½ΡΡΠΎΠ²ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ
The article presents data about study included 76 children of the first two years of life with interstitial lung diseases (ILD). According to symptoms of chILD-syndrome, all patients had respiratory signs and interstitial changes on X-ray. 93.4% of patients had respiratory symptoms, hypoxemia was revealed in 68.4% of patients by pulsoximetry. The presence of those symptoms allowed to establish chILD-syndrome in all patients, and, on the basis of clinical and laboratory-instrumental studies, nosological form was refined. Children of our study have forms of IlD such as congenital alveolar-capillary dysplasia (1.3%), pulmonary hypoplasia (17%), Wilson-Mikity syndrome (21.1%), subpleural cysts in patients with Down syndrome (6.6%), neuroendocrine cell hyperplasia of infancy (23.7%), congenital deficiency of surfactant protein B (1.3%), brain-lung-thyroid syndrome (2.6%), bronchiolitis obliterans with organizing pneumonia (10.5%), disorders related to systemic disease processes (Langerhans cell histiocytosis - 14.6%, Niemann-Pick disease - 1.3%). The features of clinical picture, data of laboratory-instrumental methods of investigation, severity of the disease's course, prognosis, predictors of the death outcome in patients with these rare diseases, have been analyzed in all patients including preterm infants.Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΎΠ± ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ, Π² ΠΊΠΎΡΠΎΡΠΎΠ΅ Π²ΠΎΡΠ»ΠΈ 76 Π΄Π΅ΡΠ΅ΠΉ ΠΏΠ΅ΡΠ²ΡΡ
2 Π»Π΅Ρ ΠΆΠΈΠ·Π½ΠΈ Ρ ΠΈΠ½ΡΠ΅ΡΡΡΠΈΡΠΈΠ°Π»ΡΠ½ΡΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ Π»Π΅Π³ΠΊΠΈΡ
(ΠΠΠ). ΠΡΠΈ ΠΎΡΠ΅Π½ΠΊΠ΅ ΡΠΈΠΌΠΏΡΠΎΠΌΠΎΠ², Π²Ρ
ΠΎΠ΄ΡΡΠΈΡ
Π² Π΄Π΅ΡΡΠΊΠΈΠΉ ΠΠΠ-ΡΠΈΠ½Π΄ΡΠΎΠΌ, Ρ Π²ΡΠ΅Ρ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΈΡΡ ΠΎΠ±ΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΈΠΌΠΏΡΠΎΠΌΡ ΠΈ ΠΈΠ½ΡΠ΅ΡΡΡΠΈΡΠΈΠ°Π»ΡΠ½ΡΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΏΠΎ Π΄Π°Π½Π½ΡΠΌ ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ. Π£ 93,4% ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΎΡΠΌΠ΅ΡΠ°Π»ΠΈΡΡ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΡΠ΅ ΡΠΈΠΌΠΏΡΠΎΠΌΡ, Ρ 68,4% ΠΏΠΎ Π΄Π°Π½Π½ΡΠΌ ΠΏΡΠ»ΡΡΠΎΠΊΡΠΈΠΌΠ΅ΡΡΠΈΠΈ Π±ΡΠ»Π° Π²ΡΡΠ²Π»Π΅Π½Π° Π³ΠΈΠΏΠΎΠΊΡΠ΅ΠΌΠΈΡ, ΡΡΠΎ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΎ ΡΡΡΠ°Π½ΠΎΠ²ΠΈΡΡ Π΄Π΅ΡΡΠΊΠΈΠΉ ΠΠΠ-ΡΠΈΠ½Π΄ΡΠΎΠΌ Ρ Π²ΡΠ΅Ρ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², Π° Π½Π° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΡ
ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΠΎ-ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π±ΡΠ»Π° ΡΡΠΎΡΠ½Π΅Π½Π° Π½ΠΎΠ·ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠΎΡΠΌΠ°. ΠΠΠ Ρ Π½Π°Π±Π»ΡΠ΄Π°Π²ΡΠΈΡ
ΡΡ Π΄Π΅ΡΠ΅ΠΉ Π²ΠΊΠ»ΡΡΠ°Π»ΠΈ Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΡΡ Π°Π»ΡΠ²Π΅ΠΎΠ»ΡΡΠ½ΠΎ-ΠΊΠ°ΠΏΠΈΠ»Π»ΡΡΠ½ΡΡ Π΄ΠΈΡΠΏΠ»Π°Π·ΠΈΡ (1,3%), Π»Π΅Π³ΠΎΡΠ½ΡΡ Π³ΠΈΠΏΠΎΠΏΠ»Π°Π·ΠΈΡ (17%), ΡΠΈΠ½Π΄ΡΠΎΠΌ ΠΠΈΠ»ΡΡΠΎΠ½Π°-ΠΠΈΠΊΠΈΡΠΈ (21,1%), ΡΡΠ±ΠΏΠ»Π΅Π²ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΊΠΈΡΡΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠΌ ΠΠ°ΡΠ½Π° (6,6%), Π½Π΅ΠΉΡΠΎΡΠ½Π΄ΠΎΠΊΡΠΈΠ½Π½ΡΡ Π³ΠΈΠΏΠ΅ΡΠΏΠ»Π°Π·ΠΈΡ ΠΌΠ»Π°Π΄Π΅Π½ΡΠ΅Π² (23,7%), Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΡΠΉ Π΄Π΅ΡΠΈΡΠΈΡ ΡΡΡΡΠ°ΠΊΡΠ°Π½ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΠΈΠ½Π° Π (1,3%), ΡΠΈΠ½Π΄ΡΠΎΠΌ Β«ΠΌΠΎΠ·Π³-Π»Π΅Π³ΠΊΠΈΠ΅-ΡΠΈΡΠΎΠ²ΠΈΠ΄Π½Π°Ρ ΠΆΠ΅Π»Π΅Π·Π°Β» (2,6%), ΠΎΠ±Π»ΠΈΡΠ΅ΡΠΈΡΡΡΡΠΈΠΉ Π±ΡΠΎΠ½Ρ
ΠΈΠΎΠ»ΠΈΡ Ρ ΠΎΡΠ³Π°Π½ΠΈΠ·ΡΡΡΠ΅ΠΉΡΡ ΠΏΠ½Π΅Π²ΠΌΠΎΠ½ΠΈΠ΅ΠΉ (10,5%), ΠΈΠ½ΡΠ΅ΡΡΡΠΈΡΠΈΠ°Π»ΡΠ½ΡΠ΅ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ Π»Π΅Π³ΠΊΠΈΡ
ΠΏΡΠΈ ΡΠΈΡΡΠ΅ΠΌΠ½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΡ
(Π³ΠΈΡΡΠΈΠΎΡΠΈΡΠΎΠ· ΠΈΠ· ΠΊΠ»Π΅ΡΠΎΠΊ ΠΠ°Π½Π³Π΅ΡΠ³Π°Π½ΡΠ° - 14,6%, Π±ΠΎΠ»Π΅Π·Π½Ρ ΠΠΈΠΌΠ°Π½Π½Π°-ΠΠΈΠΊΠ° - 1,3%). ΠΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½Ρ, Π΄Π°Π½Π½ΡΠ΅ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΠΎΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ, ΡΡΠΆΠ΅ΡΡΡ ΡΠ΅ΡΠ΅Π½ΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, ΠΏΡΠΎΠ³Π½ΠΎΠ·, Π²ΡΡΠ²Π»Π΅Π½Ρ ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΎΡΡ Π»Π΅ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΡΡ
ΠΎΠ΄Π° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π΄Π°Π½Π½ΡΠΌΠΈ ΡΠ΅Π΄ΠΊΠΈΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ Ρ Π½Π΅Π΄ΠΎΠ½ΠΎΡΠ΅Π½Π½ΡΡ
Π΄Π΅ΡΠ΅ΠΉ
The structure of interstitial lung diseases in children of the first two years of life
For the first time in Russia, the article provides data on interstitial lung diseases structure in children of the first two years of life, based on a series of observations of 68 patients with these rare diseases, as a part of multi-center ambispective study. Interstitial lung diseases in observed children included: Wilson-Mikity syndrome (23,4%), neuroendocrine hyperplasia of infancy (22%), bronchiolitis obliterans with organizing pneumonia (7,4%), primary pulmonary hypoplasia (1,5%), secondary pulmonary hypoplasia with Jeune syndrome (10,3%), secondary pulmonary hypoplasia with Edwards syndrome (2,9%), secondary pulmonary hypoplasia with other associated pathology (omphalocele - 1,5%, non-immune fetal hydrops - 1,5%), subpleural cysts in patients with Down syndrome (5,9%), congenital deficiency of surfactant protein B (1,5%), brain-lung- thyroid syndrome (2,9%), congenital alveolar-capillary dysplasia (1,5%), interstitial lung diseases with systemic diseases (Langerhans cell histiocytosis - 16,2%, Niemann-Pick disease - 1,5%). The article summarizes clinical features, the results of image diagnosis and disease outcomes. Β© 2015, Pediatria Ltd. All rights reserved
The structure of interstitial lung diseases in children of the first two years of life
For the first time in Russia, the article provides data on interstitial lung diseases structure in children of the first two years of life, based on a series of observations of 68 patients with these rare diseases, as a part of multi-center ambispective study. Interstitial lung diseases in observed children included: Wilson-Mikity syndrome (23,4%), neuroendocrine hyperplasia of infancy (22%), bronchiolitis obliterans with organizing pneumonia (7,4%), primary pulmonary hypoplasia (1,5%), secondary pulmonary hypoplasia with Jeune syndrome (10,3%), secondary pulmonary hypoplasia with Edwards syndrome (2,9%), secondary pulmonary hypoplasia with other associated pathology (omphalocele - 1,5%, non-immune fetal hydrops - 1,5%), subpleural cysts in patients with Down syndrome (5,9%), congenital deficiency of surfactant protein B (1,5%), brain-lung- thyroid syndrome (2,9%), congenital alveolar-capillary dysplasia (1,5%), interstitial lung diseases with systemic diseases (Langerhans cell histiocytosis - 16,2%, Niemann-Pick disease - 1,5%). The article summarizes clinical features, the results of image diagnosis and disease outcomes. Β© 2015, Pediatria Ltd. All rights reserved