Synthesis and biological screening of novel thiazolyl triazoles and thiadiazoles

339-344Reaction of acid hydrazide 1 with various aryl isothiocynates yields thiosemicarbazides 2. Compounds 2 gives 1,3,4-thiadiazoles 3 and 1,2,4-triazoles 4 in acidic and basic medium respectively. Newly synthesized compounds have been characterized by spectral methods like IR, 1H NMR and mass spectrometry and screened for their antimicrobial activity

Synthesis and biological screening of some novel thiazolyl chromones and pyrazoles

798-804Esterification of acid 2<span style="mso-bidi-font-weight: bold"> with 2-hydroxyacetophenones 1 yielded compounds 3 which have been converted to β-diketones 4<span style="mso-bidi-font-weight: bold"> by Baker-Venkatraman transformation. A series of 2-substituted chromones 5<span style="mso-bidi-font-weight: bold"> have been obtained by acid catalysed intramolecular cyclization of β-diketones. Substituted pyrazoles 6 have been obtained from chromones 5. All the synthesized compounds have been confirmed by the spectroscopic techniques. Chromones and pyrazoles have been evaluated for their antibacterial and antifungal efficacy. </span

<span style="font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-bidi-font-family: Mangal;mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language: HI" lang="EN-US">Novel thiadiazoles and triazoles from 4-chloro-3,5-dimethylphenol and their <i>in vitro</i> antibacterial screening</span>

687-6904-Chloro-3,5-dimethylphenol exhibits disinfectant properties. Its 1,3,4-thiadiazole and 1,2,4-triazole derivatives have been prepared. These novel compounds are characterized with the help of spectral techniques like IR, 1H NMR and mass spectrometry. These novel compounds have been screened in vitro for their antimicrobial activities