9 research outputs found
Synthesis and biological screening of novel thiazolyl triazoles and thiadiazoles
339-344Reaction of acid
hydrazide 1 with various aryl
isothiocynates yields thiosemicarbazides 2.
Compounds 2 gives
1,3,4-thiadiazoles 3 and
1,2,4-triazoles 4 in acidic and
basic medium respectively. Newly synthesized compounds have been characterized
by spectral methods like IR, 1H NMR and mass spectrometry and
screened for their antimicrobial activity
Synthesis and biological screening of some novel thiazolyl chromones and pyrazoles
798-804Esterification of
acid 2<span style="mso-bidi-font-weight:
bold"> with 2-hydroxyacetophenones 1
yielded compounds 3 which have been converted to
β-diketones 4<span style="mso-bidi-font-weight:
bold"> by Baker-Venkatraman transformation. A series of 2-substituted
chromones 5<span style="mso-bidi-font-weight:
bold"> have been obtained by acid catalysed intramolecular cyclization
of β-diketones. Substituted pyrazoles 6
have been obtained from chromones 5.
All the synthesized compounds have been confirmed by the spectroscopic
techniques. Chromones and pyrazoles have been evaluated for their antibacterial
and antifungal efficacy.
</span
<span style="font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-bidi-font-family: Mangal;mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language: HI" lang="EN-US">Novel thiadiazoles and triazoles from 4-chloro-3,5-dimethylphenol and their <i>in vitro</i> antibacterial screening</span>
687-6904-Chloro-3,5-dimethylphenol
exhibits disinfectant properties. Its 1,3,4-thiadiazole and 1,2,4-triazole
derivatives have been prepared. These novel compounds are characterized with
the help of spectral techniques like IR, 1H NMR and mass
spectrometry. These novel compounds have been screened in vitro for
their antimicrobial activities