Normocalcemic Primary Hyperparathyroidism: Need for a Standardized Clinical Approach

Since normocalcemic primary hyperparathyroidism (NHPT) was first defined at the Third International Workshop on the Management of Asymptomatic Primary Hyperparathyroidism in 2008, many papers have been published describing its prevalence and possible complications. Guidelines for the management of this condition are still lacking, and making the diagnosis requires fulfillment of strict criteria. Recent studies have shown that intermittent oscillations of serum calcium just below and slightly above the normal limits are very frequent, therefore challenging the assumption that serum calcium must be consistently normal to make the diagnosis. There is debate if these variations in serum calcium outside the normal range should be included under the rubric of NHPT or, rather, a milder form of classical primary hyperparathyroidism. Innovative approaches to define NHPT have been proposed that still need to be validated in prospective studies. Non-classical complications, especially cardiovascular complications, have been associated with NHPT, indicating that hyperparathyroidism may be a cardiovascular risk factor. New associations between parathyroid hormone (PTH) and several other comorbidities have also been reported from observational studies, suggesting that excessive PTH secretion might cause tissue dysfunction independent of serum calcium. Heterogeneous studies using different definitions of NHPT, however, make it difficult to draw definitive conclusions regarding the role of PTH excess when complications other than osteoporosis or kidney stones are described. This review will focus on clinical aspects and suggest an approach to NHPT

A high-fidelity noiseless amplifier for quantum light states

Noise is the price to pay when trying to clone or amplify arbitrary quantum states. The quantum noise associated to linear phase-insensitive amplifiers can only be avoided by relaxing the requirement of a deterministic operation. Here we present the experimental realization of a probabilistic noiseless linear amplifier that is able to amplify coherent states at the highest level of effective gain and final state fidelity ever reached. Based on a sequence of photon addition and subtraction, and characterized by a significant amplification and low distortions, this high-fidelity amplification scheme may become an essential tool for quantum communications and metrology, by enhancing the discrimination between partially overlapping quantum states or by recovering the information transmitted over lossy channels.Comment: 5 pages, 4 figure

Beewatching: A project for monitoring bees through photos

Bees play a key role in natural and agro-ecosystems and their diversity is worldwide threatened by anthropogenic causes. Despite this, there is little awareness of the existence of the numerous species of wild bees, and the common name “bee” is very often exclusively associated with Apis mellifera. Our aim was to create a citizen science project in Italy with the following objectives: (a) raising awareness of the importance and diversity of bees, (b) obtaining data on the biology, ecology and distribution of Italian species, and (c) launching the monitoring of alien bees. The first step of the project was to create a website platform with a section containing informative datasheets of the wild bee families and of the most common bee genera present in Italy, a form to send reports of observed bees and an interactive map with all citizen’s reports. During the 2 years of the project 1086 reports were sent by 269 users, with 38 Apoidea genera reported on 190 plant genera; furthermore, 22 reports regarding the alien species Megachile sculpturalis arrived. The majority of bees (34 genera) were observed on spontaneous plants, including 115 genera native to Italy. Considering the increasing number of reports and data obtained in these first two years of the project, our objectives seem to be achieved. Future steps will be to outline the profile of beewatchers, to plan activities in a more targeted way, and also to start some sub-projects for conservation purposes

Upper bounds on the relative energy difference of pure and mixed Gaussian states with a fixed fidelity

Exact and approximate formulas for the upper bound of the relative energy difference of two Gaussian states with the fixed fidelity between them are derived. The reciprocal formulas for the upper bound of the fidelity for the fixed value of the relative energy difference are obtained as well. The bounds appear higher for pure states than for mixed ones, and their maximal values correspond to squeezed vacuum states. In particular, to guarantee the relative energy difference less than 10%, for quite arbitrary Gaussian states, the fidelity between them must exceed the level 0.998866.Comment: 9 pages, accepted for publication in Journal of Physics

Single-photon excitation of a coherent state: catching the elementary step of stimulated light emission

When a single quantum of electromagnetic field excitation is added to the same spatio-temporal mode of a coherent state, a new field state is generated that exhibits intermediate properties between those of the two parents. Such a single-photon-added coherent state is obtained by the action of the photon creation operator on a coherent state and can thus be regarded as the result of the most elementary excitation process of a classical light field. Here we present and describe in depth the experimental realization of such states and their complete analysis by means of a novel ultrafast, time-domain, quantum homodyne tomography technique clearly revealing their non-classical character.Comment: 9 pages, 9 figures. Accepted for publication in Phys. Rev.

Numerical Investigation of Al-Reinforced CFRP Composite under Low-Velocity Impact

Fibre-reinforced composite materials are widespread in lightweight, high-performance applications. However, polymeric composites generally exhibit a brittle behaviour, which makes them susceptible to impact damage. Even low-velocity impacts can produce delaminations, which cause a substantial reduction of the compressive mechanical properties. Metallic layers have been embedded in composite laminates with the aim to improve their fracture behaviour: aluminium plies can be employed to increase the indentation resistance of Carbon Fibre Reinforced Polymers (CFRP) specimens. For this reason, hybrid fibre-metal laminates are expected to be a viable solution to reduce the damage caused by low-velocity impacts. In this work, CFRP specimens reinforced with aluminium plies were modelled using the finite element method and a cohesive zone model. Cohesive elements based on a traction-separation formulation were embedded at each ply-to-ply interface to enforce delamination damage. Different configurations of the Al reinforcements were studied by varying the position of the aluminium layers between the CFRP plies

Experimental Study of Noise-induced Phase Synchronization in Vertical-cavity Lasers

We report the experimental evidence of noise-induced phase synchronization in a vertical cavity laser. The polarized laser emission is entrained with the input periodic pump modulation when an optimal amount of white, gaussian noise is applied. We characterize the phenomenon, evaluating the average frequency of the output signal and the diffusion coefficient of the phase difference variable. Their values are roughly independent on different waveforms of periodic input, provided that a simple condition for the amplitudes is satisfied. The experimental results are compared with numerical simulations of a Langevin model

Minimax estimation of the Wigner function in quantum homodyne tomography with ideal detectors

We estimate the quantum state of a light beam from results of quantum homodyne measurements performed on identically prepared pulses. The state is represented through the Wigner function, a ``quasi-probability density'' on $\mathbb{R}^{2}$ which may take negative values and must respect intrinsic positivity constraints imposed by quantum physics. The data consists of $n$ i.i.d. observations from a probability density equal to the Radon transform of the Wigner function. We construct an estimator for the Wigner function, and prove that it is minimax efficient for the pointwise risk over a class of infinitely differentiable functions. A similar result was previously derived by Cavalier in the context of positron emission tomography. Our work extends this result to the space of smooth Wigner functions, which is the relevant parameter space for quantum homodyne tomography.Comment: 15 page

Avalanche Photo-Detection for High Data Rate Applications

Avalanche photo detection is commonly used in applications which require single photon sensitivity. We examine the limits of using avalanche photo diodes (APD) for characterising photon statistics at high data rates. To identify the regime of linear APD operation we employ a ps-pulsed diode laser with variable repetition rates between 0.5MHz and 80MHz. We modify the mean optical power of the coherent pulses by applying different levels of well-calibrated attenuation. The linearity at high repetition rates is limited by the APD dead time and a non-linear response arises at higher photon-numbers due to multiphoton events. Assuming Poissonian input light statistics we ascertain the effective mean photon-number of the incident light with high accuracy. Time multiplexed detectors (TMD) allow to accomplish photon- number resolution by photon chopping. This detection setup extends the linear response function to higher photon-numbers and statistical methods may be used to compensate for non-linearity. We investigated this effect, compare it to the single APD case and show the validity of the convolution treatment in the TMD data analysis.Comment: 16 pages, 5 figure