Mind reading with cognition for treatment

Mind is mysterious and complex. Thoughts were transferred from one mind to the other mind by cognitive domains and senses. The scientific information is based on observation and analysis, and research may benefit the most through initial real information. We have a virtual area in mind; this area can help us for cognition of patients even if they do not speak. Physicians, nurses, therapists, care givers can understand thought of patients with mind reading for the successful treatment. Hence it shows the need for a modern approach to the mind reading in medical science for novel treatment

Continuous Performance Test for assessing cognition among patients with Parkinson diseases

Background: Many patients with Parkinson diseases are faced with constant attention disorders and evaluation of these disorders in these patients is important. Methods: A cross-sectional study was conducted on 80 patients with Parkinson disease and 80 healthy Iranian people aged 40 to 70. All participants in the two groups of healthy and patients were examined by neurologists and psychiatrists. After completing the questionnaire, they were evaluated through computerized cognitive Continuous Performance Test.Results: There was significance difference between the two groups in age, sex and education status and in some variables of the test (p<0.05). Patients compared with healthy controls and showed a significant difference in test variables (p<0.05). Conclusion: Patients with Parkinson disease compared to healthy subjects face cognitive changes in sustained attention, and identification and evaluation of cognitive changes before and after treatment will be a considerable help in the rehabilitation of brain and a better quality of life for these patients

A study of relationship between love with depression and anxiety in married individuals

Purpose: This study was conducted to determine the relationship between depression and anxiety with loveamong married peoples. Methods: It was a post event study performed on 90 married peoples and the sample was randomly selected. Married people were invited to volunteer by calling and they were entered to study after filling consent form. Then participants were evaluated by demographic, Boston stern Norse Love, Beck Depression and Hamilton Anxiety questionnaires. Results: Based on the performance assessment of participants a significant inverse relationship was observed between love with depression and anxiety (P<0.05) and simulated love reduces depression and anxiety. Conclusion: Increased love was associated with reduced depression and anxiety. It seems mental disorders could be reduced by creating favorable positions for romantic sentiment in the family

Assessment of Cognitive Impairments, Depression, Anxiety and Quality of Life among Brain Tumor Patients and Healthy Adults

Purpose: This study was conducted to assess cognitive impairments, depression, anxiety and quality of life among patients with brain tumor and healthy adults, comparatively.Methods: A cross-sectional study was administrated on 84 brain tumor patients and 84 healthy adults measured by the mini mental state examination, Beck, Hamilton and SF36 questionnaires before and after 10 days of surgery.Results: This study showed that cognitive impairment, depression and anxiety increased in brain tumor patients after surgery but quality of life did not changed.Conclusion: Findings of current study show the necessity of cognitive and mental assessments before and after surgery and emphasizes on the need for rehabilitation and treatment.

Memory Editing with Emphasizing the Role of EM in EMDR

Eye Movement Desensitization and Reprocessing (EMDR) process encompasses several nervous system components such as medulla, pons, midbrain, cerebellum, basal ganglia, parietal, frontal and occipital lobes. The role of Eye Movement (EM) has been documented previously in relation with cognitive processing mechanisms. By EMDR we can reach some parts of memory which were inaccessible before and also emotionally intolerable. EM also decreases the memory's image clarity and the accompanying excitement and it is done simultaneously for gaining patient's attention to an external stimulus when he/she is concentrating on a certain internal subject. A series of systemic experiments have shown that the eyes spontaneous movement is associated with emotional and memory changes and results into decreased excitement, flexibility in attention, memory processing, and enhanced semantic recalling. Researches emphasize on the effectiveness of EMDR in memory changes and memory washing.

Neuroscience approach in Stem cell therapy among patients with Spinal Cord Injury

The first necessary step in researches to treat spinal cord injuries (SCI) is to understand complexities related to the neurophysiology and neurobiology changes of human SCI with stem cell therapy(SCT). The aim of this study is to identify these changes. The level of injuries is important in treatment and determination of this injury (whether it is complete, incomplete, or discomplete) is valuable too. Loss of all neurological functions affected by this injury and physiological or anatomical continuity of central nervous system tracts occur across this lesion. Obviously, a result that is achieved is that the maximum number of tracts can remain, be maintained, and increase in the acute phase of illness. Stimulating the axonal regeneration by neutralizing inhibitory factors, adding positive tropisms, and creating a permissive environment is suitable. Better results that had been obtained are achieved by filling gaps with peripheral nerve grafts or transplanting Schwann cells, and fibroblasts that genetic engineering has been done on them. Ability of poly potential cells to differentiate and create neural tissues is remarkable. The relatively good success in obtaining the proper repair for axons has been reported. However, this issue also should be considered that human spinal cord injuries have significant differences with spinal cord injuries in laboratory animals. In order to be successful in doing this research, the changes of human SCI must also be considered and the use of stem cells in treating human SCI must be performed due to these changes

QSAR Modeling of COX-2 Inhibitory Activity of Thiazinan, Benzthiazinan and Benzdiazinan Derivatives

COX-2 inhibitory activities of some thiazinan, benzdiazinan and benzthiazinan derivatives were modeled by quantitative structure–activity relationship (QSAR) with stepwise-multiple linear regression (SW-MLR) method. The built model was robust and predictive with correlation coefficient (R2) of 0.840 for training and 0.522 for test groups. The quality of the model was evaluated by leave-one out (LOO) cross validation and LOO correlation coefficient (Q2) was 0.639. We also investigated a leverage approach for defining of applicability domain of model. According to QSAR model results, COX-2 inhibitory activity of selected data set had correlation with VE3_Dzm (Logarithmic coefficient sum of the last eigenvector from Barysz matrix weighted by mass), GATS6c (geometrical structure of the considered molecules in a complex way) and GATS5i (Geary autocorrelation of lag 5 weighted by ionization potential) descriptors which derived from their structures

Design, synthesis and docking studies of novel anti-HIV agents

Introduction: AIDS therapeutic targets principally consists of three enzymes: reverse transcriptase (RT), protease (PR) and integrase (IN). Integrase strand transfer inhibitors among the HIV inhibitors has the advantage of suitable safety profile and high potency. The chelating motif and coplanar hydrophobic aryl group are the common pharmacophores of an integrase strand transfer inhibitor (INSTI). According to the cyclic chelating group of dolutegravir, we incorporated the chelating group into a cyclic motif and novel 2-mercaptooxazoloxocumarin tricyclic scaffold was designed. Hydrophobic part of the ligand was attached through s-arylation to occupy the same position as the halobenzyl pharmacophoric group of INSTIs. Methods and Results: 4-Hydroxy-3-nitro coumarin was prepared in a nitration procedure of 4-hydroxy coumarin with the aid of concentrated nitric acid and sulfuric acid. Reduction of the 4-hydroxy-3-nitro coumarin in the presence of sodium dithionite and sodium acetate in water gave the 3-amino-4-hydroxy coumarin. 2-Mercaptooxazolocoumarin was prepared by the reaction of carbon disulfide with 3-amino-4-hydroxy coumarin in methanolic potassium hydroxide. Then, this intermediate was treated with substituted benzyl halides in the presence of potassium carbonate and acetone. Final derivatives were recrystallized from ethanol and confirmed by IR, LC-MS (ESI), 1HNMR & 13CNMR. According to the docking results, the tricyclic scaffold could п-stack the 3’-end reactive adenosine in the IN active site just same as the co-crystallized ligand dolutegravir and the ligand heteroatoms complexes the magnesium cofactors in the IN. Conclusions: Here, we introduced a novel scaffold for anti-HIV activity. The superimposed structure with co-crystallized ligand dolutegravir confirmed the potential for integrase inhibitory activity just same as the second generation integrase inhibitor dolutegravir

Removal of Estrogen Hormones (17-Estradiol and Estrone) from Aqueous Solutions Using Rice Husk Silica

The aim of this study was to investigate the removal of estrogen hormones (17β-estradiol and estrone) from aqueous solutions using rice husk extracted silica. Rice husk was collected from rice factories in Mazandaran province (Iran) and the adsorbent was prepared in a furnace at 800 °C for 4 h, after acid leaching with hydrochloric and sulfuric acid mixture. Optimal operating parameters for estrogen removal were determined, including initial pH values (4–9), adsorbent dosages (0.5, 1, 1.5, and 2 g L–1), contact times (30, 60, 90, and 120 min), and initial concentrations of 17β-estradiol and estrone (10, 40, 70 and 100 ng L–1); one-factor-at-a-time method was used. The method of electrochemiluminescence was used to measure the concentration of hormones. Kinetic adsorption models and adsorption isotherms were also studied. The maximum removal efficiency (%) of 17β-estradiol (E2) and estrone (E1) hormones of 95.5 and 93.1 %, respectively, was obtained at optimal conditions of pH 4, 1.5 g L–1 of adsorbent dosage, 60 min of contact time and 10 ng L–1 initial concentrations of E2 and E1. Pseudo first-order kinetic model and Langmuir adsorption isotherm had the best fit with experimental data for both estrogen hormones, following nonlinear regression procedure. Rice husk silica could be considered as effective and accessible adsorbent for removal of estrogenic hormones. This work is licensed under a Creative Commons Attribution 4.0 International License

Association between Body Mass Index and Cognitive Performance.

Background: Because of well-established role of obesity in brain lesions, progressing cognitive deficits in obese patients has been recently suggested. In current study and for the first time, we aimed to assess cognition status in Iranian obese people and to compare it with non-obese individuals.Methods: One hundred and eighteen consecutive patients with the different cardiovascular and metabolic primary complaints were assigned to obese group (n = 25, 21.2%) and non-obese group (n = 93, 78.8%). Cognitive status was assessed at initial visiting using the Montreal Cognitive Assessment (MoCA) questionnaire.Results: Mean total cognitive score in obese patients was 20.04 ± 4.57 and in non-obese ones was 20.19 ± 5.32 with no difference (p = 0.886). In total, 8.0% of obese patients and 20.4% of non-obese patients had normal cognitive function (p = 0.149). No significant difference was also found in different subdomains of cognitive ability between obese and non-obese groups. None of the cognitive domains had significant association with BMI as the considered indicator for defining obesity. Based on multivariate linear regression modeling, obesity could not predict cognitive deficit (beta = 0.034, SE = 0.1.015, p = 0.973).Conclusion: Our survey could not demonstrate an association obesity and cognitive impairment in a sample of Iranian patients