Using a multi-lens framework for landscape decisions

1. Landscape decisions are multi-faceted. Framing landscape decision-making as a governance process that requires a collective approach can encourage key stakeholders to come together to co-inform a discussion about their priorities and what constitutes good governance, leading to more holistic landscape decisions. 2. In this paper, we recognise that a suite of complementary and multi-dimensional approaches are in practice used to inform and evaluate land use decisions. We have called these approaches ‘lenses’ because they each provide a different perspective on the same problem. The four lenses are: i) Power and Market Gain, ii) Ecosystem Services, iii), Place-based Identity and iv) Ecocentric. Each brings a different set of evidence and viewpoints (narrative, qualitative and experiential, as well as quantitative metrics such as monetary) to the decision-making process and can potentially reveal problems and solutions that others do not. 3. Considering all lenses together allows dialogue to take place which can reveal the true complexities of landscape decision-making and can facilitate more effective and more holistic decisions. Employing the lenses requires governance structures that give equal weight to all lenses, enable dialogue and coexistence between top down and bottom-up approaches, and permit adaptation to local and granular place-specifics rather than developing “one-size-fits-all” solutions. 4. We propose that formalising the process of balancing all the lenses requires public participation, and that a lens approach should be used to support landscape decisions alongside a checklist that facilitates transparency in the conversation, showing how all evidence has been considered and critically assessed

Do remittances and social assistance have different impacts on expenditure patterns of recipient households? : The Moldovan case

Do remittances and social assistance have different impacts on household expenditure patterns? While two separate strands of literature have looked at how social assistance or remittances have been spent, few studies have compared them directly. Using data from a nationally representative household survey conducted in Moldova in 2011, this paper assesses the impact both types of transfers have on household expenditure patterns. Contrary to the common assumption that money is fungible, we find that social assistance and remittances have different impacts on expenditure patterns (having controlled for potential endogeneity). This research highlights that income source matters and that different incomes may have different poverty impacts. In our sample, the two types of transfers are received by different, but to some extent overlapping population groups. The fact that the two transfers are spent in different ways means that, to some extent, social assistance and remittances are complements rather than substitutes

Reviews

The following publications have been reviewed by the mentioned authors;Art and Society One. War by Ken Baynes, reviewed by Ronald FrankenbergArt and Society Two. Work by Ken Baynes and Alan Robinson, reviewed by Ronald FrankenbergArt and Society Three. Worship by Ken and Kate Baynes, reviewed by Ronald FrankenbergArt and Science by Dolf Rieser, reviewed by M. K. PaffardA COMMON SYSTEM OF EXAMINING AT 16+ by the Schols Council Examinations Bulletin No.23, reviewed by W. G. SkinnerSchool Resource Centres, the Schools Council Working Paper 43, reviewed by L. BroughA History of English Furniture by John Harrison, reviewed by S. J. EgglestonTrends in School Design by Eric Pearson, reviewed by P. K. BodenWorking Space, A Place to Paint, Language Aeas by Jason Dean, reviewed by P. K. BodenAlive to Art by Jose Llobera, reviewed by John LancasterVisual Education in the primary school by John M. Pickering, reviewed by L. BroughArt & Design Cards. Packs 1 & 2 by Ian Pillinger, reviewed by Francis ZankerWorkshop Assignments, Book One by S. Dunkerley & A. Huxton, reviewed by L. BroughStep By Step Metalwork, Book 3 by Kenneth Wells, reviewed by M. SayerIntroducing Jewellery Making by John Crawford, reviewed by John DecorteMaggie Hayes Jewellery Book by Maggie Hayes, reviewed by S. J. Egglesto

Autism in England: assessing underdiagnosis in a population- based cohort study of prospectively collected primary care data

Background: Autism has long been viewed as a paediatric condition, meaning that many autistic adults missed out on a diagnosis as children when autism was little known. We estimated numbers of diagnosed and undiagnosed autistic people in England, and examined how diagnostic rates differed by socio-demographic factors. Methods: This population-based cohort study of prospectively collected primary care data from IQVIA Medical Research Data (IMRD) compared the prevalence of diagnosed autism to community prevalence to estimate underdiagnosis. 602,433 individuals registered at an English primary care practice in 2018 and 5,586,100 individuals registered between 2000 and 2018 were included. Findings: Rates of diagnosed autism in children/young people were much higher than in adults/older adults. As of 2018, 2.94% of 10- to 14-year-olds had a diagnosis (1 in 34), vs. 0.02% aged 70+ (1 in 6000). Exploratory projections based on these data suggest that, as of 2018, 463,500 people (0.82% of the English population) may have been diagnosed autistic, and between 435,700 and 1,197,300 may be autistic and undiagnosed (59–72% of autistic people, 0.77%–2.12% of the English population). Age-related inequalities were also evident in new diagnoses (incidence): c.1 in 250 5- to 9-year-olds had a newly-recorded autism diagnosis in 2018, vs. c.1 in 4000 20- to 49-year-olds, and c.1 in 18,000 people aged 50+. Interpretation: Substantial age-related differences in the proportions of people diagnosed suggest an urgent need to improve access to adult autism diagnostic services. Funding: Dunhill Medical Trust, Economic and Social Research Council, Medical Research Council, National Institute for Health Research, the Wellcome Trust, and the Royal College of Psychiatrists.</p

Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning

The mechanisms by which astrocytes modulate neural homeostasis, synaptic plasticity, and memory are still poorly explored. Astrocytes form large intercellular networks by gap junction coupling, mainly composed of two gap junction channel proteins, connexin 30 (Cx30) and connexin 43 (Cx43). To circumvent developmental perturbations and to test whether astrocytic gap junction coupling is required for hippocampal neural circuit function and behavior, we generate and study inducible, astrocyte-specific Cx30 and Cx43 double knockouts. Surprisingly, disrupting astrocytic coupling in adult mice results in broad activation of astrocytes and microglia, without obvious signs of pathology. We show that hippocampal CA1 neuron excitability, excitatory synaptic transmission, and long-term potentiation are significantly affected. Moreover, behavioral inspection reveals deficits in sensorimotor performance and a complete lack of spatial learning and memory. Together, our findings establish that astrocytic connexins and an intact astroglial network in the adult brain are vital for neural homeostasis, plasticity, and spatial cognition

Estimating life expectancy and years of life lost for autistic people in the UK: a matched cohort study

Background Previous research has shown that people who have been diagnosed autistic are more likely to die prematurely than the general population. However, statistics on premature mortality in autistic people have often been misinterpreted. In this study we aimed to estimate the life expectancy and years of life lost experienced by autistic people living in the UK. Methods We studied people in the IQVIA Medical Research Database with an autism diagnosis between January 1, 1989 and January 16, 2019. For each participant diagnosed autistic, we included ten comparison participants without an autism diagnosis, matched by age, sex, and primary care practice. We calculated age- and sex-standardised mortality ratios comparing people diagnosed autistic to the reference group. We used Poisson regression to estimate age-specific mortality rates, and life tables to estimate life expectancy at age 18 and years of life lost. We analysed the data separately by sex, and for people with and without a record of intellectual disability. We discuss the findings in the light of the prevalence of recorded diagnosis of autism in primary care compared to community estimates. Findings From a cohort of nearly 10 million people, we identified 17,130 participants diagnosed autistic without an intellectual disability (matched with 171,300 comparison participants), and 6450 participants diagnosed autistic with an intellectual disability (matched with 64,500 comparison participants). The apparent estimates indicated that people diagnosed with autism but not intellectual disability had 1.71 (95% CI: 1.39–2.11) times the mortality rate of people without these diagnoses. People diagnosed with autism and intellectual disability had 2.83 (95% CI: 2.33–3.43) times the mortality rate of people without these diagnoses. Likewise, the apparent reduction in life expectancy for people diagnosed with autism but not intellectual disability was 6.14 years (95% CI: 2.84–9.07) for men and 6.45 years (95% CI: 1.37–11.58 years) for women. The apparent reduction in life expectancy for people diagnosed with autism and intellectual disability was 7.28 years (95% CI: 3.78–10.27) for men and 14.59 years (95% CI: 9.45–19.02 years) for women. However, these findings are likely to be subject to exposure misclassification biases: very few autistic adults and older-adults have been diagnosed, meaning that we could only study a fraction of the total autistic population. Those who have been diagnosed may well be those with greater support needs and more co-occurring health conditions than autistic people on average. Interpretation The findings indicate that there is a group of autistic people who experience premature mortality, which is of significant concern. There is an urgent need for investigation into the reasons behind this. However, our estimates suggest that the widely reported statistic that autistic people live 16-years less on average is likely incorrect. Nine out of 10 autistic people may have been undiagnosed across the time-period studied. Hence, the results of our study do not generalise to all autistic people. Diagnosed autistic adults, and particularly older adults, are likely those with greater-than-average support needs. Therefore, we may have over-estimated the reduction in life expectancy experienced by autistic people on average. The larger reduction in life expectancy for women diagnosed with autism and intellectual disability vs. men may in part reflect disproportionate underdiagnosis of autism and/or intellectual disability in women

Modelling Drosophila motion vision pathways for decoding the direction of translating objects against cluttered moving backgrounds

Decoding the direction of translating objects in front of cluttered moving backgrounds, accurately and efficiently, is still a challenging problem. In nature, lightweight and low-powered flying insects apply motion vision to detect a moving target in highly variable environments during flight, which are excellent paradigms to learn motion perception strategies. This paper investigates the fruit fly Drosophila motion vision pathways and presents computational modelling based on cuttingedge physiological researches. The proposed visual system model features bio-plausible ON and OFF pathways, wide-field horizontal-sensitive (HS) and vertical-sensitive (VS) systems. The main contributions of this research are on two aspects: (1) the proposed model articulates the forming of both direction-selective and direction-opponent responses, revealed as principalfeaturesofmotionperceptionneuralcircuits,inafeed-forwardmanner;(2)italsoshowsrobustdirectionselectivity to translating objects in front of cluttered moving backgrounds, via the modelling of spatiotemporal dynamics including combination of motion pre-filtering mechanisms and ensembles of local correlators inside both the ON and OFF pathways, which works effectively to suppress irrelevant background motion or distractors, and to improve the dynamic response. Accordingly, the direction of translating objects is decoded as global responses of both the HS and VS systems with positive ornegativeoutputindicatingpreferred-direction or null-direction translation.The experiments have verified the effectiveness of the proposed neural system model, and demonstrated its responsive preference to faster-moving, higher-contrast and larger-size targets embedded in cluttered moving backgrounds