143 research outputs found
Update on the GRB universal scaling E-E-E with ten years of data
From a comprehensive statistical analysis of X-ray light-curves of
gamma-ray bursts (GRBs) collected from December 2004 to the end of 2010, we
found a three-parameter correlation between the isotropic energy emitted in the
rest frame 1-10 keV energy band during the prompt emission
(E), the rest frame peak of the prompt emission energy
spectrum (E), and the X-ray energy emitted in the rest frame 0.3-30
keV observed energy band (E), computed excluding the
contribution of the flares. In this paper, we update this correlation with the
data collected until June 2014, expanding the sample size with 35% more
objects, where the number of short GRBs doubled. With this larger sample we
confirm the existence of a universal correlation that connects the prompt and
afterglow properties of long and short GRBs. We show that this correlation does
not depend on the X-ray light-curve morphology and that further analysis is
necessary to firmly exclude possible biases derived by redshift measurements.
In addition we discuss about the behavior of the peculiar objects as ultra-long
GRBs and we propose the existence of an intermediate group between long and
short GRBs. Interestingly, two GRBs with uncertain classification fall into
this category. Finally, we discuss the physics underlying this correlation, in
the contest of the efficiency of conversion of the prompt -ray emission
energy into the kinetic energy of the afterglow, the photosferic model, and the
cannonball model.Comment: 11 pages, 5 figures, accepted for publication in MNRA
New measurements of from gamma-ray bursts
Context: Data from cosmic microwave background radiation (CMB), baryon
acoustic oscillations (BAO), and supernovae Ia (SNe-Ia) support a constant dark
energy equation of state with . Measuring the evolution of
along the redshift is one of the most demanding challenges for observational
cosmology. Aims: We discuss the existence of a close relation for GRBs, named
Combo-relation, based on characteristic parameters of GRB phenomenology such as
the prompt intrinsic peak energy , the X-ray afterglow, the initial
luminosity of the shallow phase , the rest-frame duration of the
shallow phase, and the index of the late power-law decay . We use it
to measure and the evolution of the dark energy equation of state.
We also propose a new calibration method for the same relation, which reduces
the dependence on SNe Ia systematics. Methods: We have selected a sample of
GRBs with 1) a measured redshift ; 2) a determined intrinsic prompt peak
energy , and 3) a good coverage (0.3-10) keV afterglow light curves.
The fitting technique of the rest.frame (0.3-10) keV luminosity light curves
represents the core of the Combo-relation. We separate the early steep decay,
considered a part of the prompt emission, from the X-ray afterglow additional
component. Data with the largest positive residual, identified as flares, are
automatically eliminated until the p-value of the fit becomes greater than 0.3.
Results: We strongly minimize the dependency of the Combo-GRB calibration on
SNe Ia. We also measure a small extra-Poissonian scatter of the Combo-relation,
which allows us to infer from GRBs alone
(1) for the CDM cosmological model, and , for the flat-Universe
variable equation of state case.Comment: 10 pages, 9 figures, 3 tables. Accepted for publication in A&A.
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The X-ray light curve of Gamma-ray bursts: clues to the central engine
We present the analysis of a large sample of gamma-ray burst (GRB) X-ray
light curves in the rest frame to characterise their intrinsic properties in
the context of different theoretical scenarios. We determine the morphology,
time scales, and energetics of 64 long GRBs observed by \emph{Swift}/XRT
\emph{without} flaring activity. We furthermore provide a one-to-one comparison
to the properties of GRBs \emph{with} X-ray flares. We find that the steep
decay morphology and its connection with X-ray flares favour a scenario in
which a central engine origin. We show that this scenario can also account for
the shallow decay phase, provided that the GRB progenitor star has a
self-similar structure with a constant envelope-to-core mass ratio . However, difficulties arise for very long duration
( s) shallow phases. Alternatively, a spinning-down magnetar
whose emitted power refreshes the forward shock can quantitatively account for
the shallow decay properties. In particular we demonstrate that this model can
account for the plateau luminosity vs. end time anticorrelation.Comment: 12 pages, 8 figures, accepted for publication in A&
Gamma-ray bursts and their X-ray and optical afterglow
The aim of this PhD thesis is to study and characterize the optical and X-ray emission of the afterglows of gamma-ray bursts (GRBs).
GRBs are the most powerful sources of electromagnetic radiation in the universe, with an isotropic luminosity that can reach values of erg/s. The Swift satellite, launched in November 2004, opened a new era for the study and understanding of the phenomenon of GRBs, thanks to the rapid response of its narrow FOV instruments that allows the accurate localization of most GRBs and the more complete coverage of the GRB evolution.
In the first part of my PhD I was involved in a comprehensive statistical analysis of the Swift X-ray light-curves (LCs) of GRBs, carried out in a model-independent way. Our sample is composed of the X-ray LCs of more than 650 GRBs observed by Swift from December 2004 to December 2010. For 437 GRBs the statistics were good enough to allow us to extract a spectrum to convert their count-rate LCs into flux LCs. For GRBs with a known redshift, also rest-frame luminosity LCs in the 0.3-30 keV band were computed. From the fit of these LCs, we obtained the values of the temporal slopes and break times of the continuum of the X-ray emission, since the used fitting procedure automatically discards the positive fluctuations (i.e. flares). Then, we computed the total fluences and energies, those of flares and differentiating between the components of the X-ray LCs. Thanks to this large sample of LCs, we could carry out a homogeneous analysis of GRBs in a common rest frame energy band (0.3-30 keV), investigating the intrinsic time scales and energetics of the different LC phases. In addition, we studied the properties of flares superimposed to the smooth X-ray decay. GRBs are classified as long and short, depending on the duration of the prompt emission (T90>2 s and T90<2 s, respectively); our sample of GRBs allowed us to investigate the possible differencies and similarities between these two classes, for example the nature of long and short GRBs and the emission mechanisms involved. Finally, we examined the possible relation between the X-ray and gamma-ray emission and we found the existence of a universal scaling involving two parameters of the prompt emission and one of the X-ray emission: the isotropic prompt emission energy (), the peak energy () and the isotropic X-ray energy ().
The main idea of the project presented above is to study all quantities that characterize the X-ray data and to look for a link between prompt and afterglow emission. During this work, we realized that the optical data were very important for our understanding, adding information to investigate the GRB emission mechanisms and to study the environment properties. Therefore, in the second part of my PhD we carried out a systematic analysis of the optical data available in literature, collecting data from all the available sources. From the collected optical data, we determine the shapes of the optical LCs. Then, we modeled the optical/X-ray spectral energy distribution (SED), we studied the SED parameter distributions and we compared the optical and X-ray LC slopes and shapes. For 20% of GRBs the difference between the optical and X-ray slopes is consistent with 0 or 1/4 within uncertainties (we do not consider here the steep decay phase), but in the majority of cases (80%) the optical and X-ray afterglows show significantly different temporal behaviors. Interestingly, we found an indication that the onset of the forward shock in the optical LCs (initial peaks or shallow phases) could be linked to the presence of the X-ray flares. Indeed when there are X-ray flares the optical LC initial peak or plateau end occurs during the steep decay, instead if there are no X-ray flares or if they occur during the plateau, the optical initial peak or plateau end takes place during the X-ray plateau. This could link the prompt emission with the optical emission. The forward shock model cannot explain all the features of the optical (e.g. bumps, late re-brightenings) and X-ray (e.g. flares, plateaus) LCs. However, the synchrotron model is a viable mechanism for GRBs afterglow emission at late times. Further to the intrinsic spectrum of the afterglow, the SED analysis allows to study the properties of the GRB environment, by quantifying the amount of absorption at optical and X-ray wavelengths. The first is due to dust while the latter is mostly due to metals. Our analysis shows that the gas-to-dust ratios of GRBs are larger than the values calculated for the Milky Way, the Large Magellanic Cloud, and the Small Magellanic Cloud assuming solar abundances
Management of refractory autoimmune hemolytic anemia after allogeneic hematopoietic stem cell transplantation : current perspectives
Autoimmune hemolytic anemia (AIHA) is increasingly observed after allogeneic hematopoietic stem cell transplantation (allo-HSCT), with a reported incidence between 4% and 6%. The disease is generally severe and refractory to standard therapy, with high mortality, and there are neither defined therapies, nor prospective clinical trials addressing the best treatment. Most of the knowledge on the therapy of AIHAs derives from primary forms, which are highly heterogeneous as well, further complicating the management of post-allo-HSCT forms. The review addresses the risk factors associated with post-allo-AIHA, including unrelated donor, the development of chronic extensive graft-versus-host disease, CMV reactivation, nonmalignant diagnosis pre-HSCT, and alemtuzumab use in conditioning regimens. Regarding therapy, we describe standard treatments, such as corticosteroids, intravenous immunoglobulin, splenectomy, rituximab, cyclophosphamide, and plasma exchange, which have lower response rates than those reported in primary forms. New therapeutic options, including sirolimus, bortezomib, abatacept, daratumumab and complement inhibitors, are promising tools for this detrimental complication occurring after allo-HSCT
Gamma-ray burst optical light-curve zoo: comparison with X-ray observations
We present a comprehensive analysis of the optical and X-ray light curves
(LCs) and spectral energy distributions (SEDs) of a large sample of gamma-ray
burst (GRB) afterglows to investigate the relationship between the optical and
X-ray emission after the prompt phase. We collected the optical data from the
literature and determined the shapes of the optical LCs. Then, using previously
presented X-ray data we modeled the optical/X-ray SEDs. We studied the SED
parameter distributions and compared the optical and X-ray LC slopes and
shapes. The optical and X-ray spectra become softer as a function of time while
the gas-to-dust ratios of GRBs are higher than the values calculated for the
Milky Way and the Large and Magellanic Clouds. For 20% of the GRBs the
difference between the optical and X-ray slopes is consistent with 0 or 1=4
within the uncertainties (we did it not consider the steep decay phase), while
in the remaining 80% the optical and X-ray afterglows show significantly
different temporal behaviors. Interestingly, we find an indication that the
onset of the forward shock in the optical LCs (initial peaks or shallow phases)
could be linked to the presence of the X-ray flares. Indeed, when X-ray flares
are present during the steep decay, the optical LC initial peak or end plateau
occurs during the steep decay; if instead the X-ray flares are absent or occur
during the plateau, the optical initial peak or end plateau takes place during
the X-ray plateau. The forward-shock model cannot explain all features of the
optical (e.g. bumps, late re-brightenings) and X-ray (e.g. flares, plateaus)
LCs. However, the synchrotron model is a viable mechanism for GRBs at late
times. In particular, we found a relationship between the presence of the X-ray
flares and the shape of the optical LC that indicates a link between the prompt
emission and the optical afterglow.Comment: 55 pages, 37 figures, accepted for publication in A&A (this version
includes changes made at Proofs stage
Small Paroxysmal Nocturnal Hemoglobinuria Clones in Autoimmune Hemolytic Anemia: Clinical Implications and Different Cytokine Patterns in Positive and Negative Patients
Autoimmune hemolytic anemia (AIHA) is characterized by immune mediated erythrocytes destruction by autoantibodies with or without complement activation. Additional pathologic mechanisms include cellular cytotoxicity, cytokline dysregulation, and inadequate bone marrow compensation with fibrosis/dyserythropoiesis. The latter resembles that of bone marrow failures, namely aplastic anemia and myelodysplastic syndromes. Paroxysmal nocturnal hemoglobinuria (PNH) clones are increasingly recognized in bone marrow failure syndromes, and their selection and expansion are thought to be mediated by immune mechanisms. In this study, we aimed to evaluate the prevalence of PNH clones in 99 patients with primary AIHA, and their correlations with disease features and outcomes. Moreover, in the attempt to disclose the physiopathology of PNH positivity in AIHA, serum levels of several immunomodulatory cytokines were tested. A PNH clone was found in 37 AIHA patients (37,4%), with a median size of 0.2% on granulocytes (range 0.03\u201385). Two patients showed a large clone (16 and 85%) and were therefore considered as AIHA/PNH association and not included in further analysis. Compared to PNH negative, PNH positive cases displayed a higher hemolytic pattern with adequate bone marrow compensation. AIHA type, response to therapy, complications and outcome were comparable between the two groups. Regarding cytokine levels, IFN-\u3b3 and IL-17 were lower in PNH positive vs. PNH negative AIHAs (0.3 \ub1 0.2 vs. 1.33 \ub1 2.5; 0.15 \ub1 0.3 vs. 3,7 \ub1 9.1, respectively, p = 0.07 for both). In PNH positive AIHAs, IFN-\u3b3 positively correlated with reticulocytes (r = 0.52, p = 0.01) and with the bone marrow responsiveness index (r = 0.69, p = 0.002). Conversely, IL-6 and IL-10 showed the same pattern in PNH positive and PNH negative AIHAs. IL-6 levels and TGF-\u3b2 positively correlated with clone size (r = 0.35, p = 0.007, and r = 0.38, p = 0.05, respectively), as well as with LDH values (r = 0.69, p = 0.0003, and r = 0.34, p = 0.07, respectively). These data suggest testing PNH clones in AIHA since their prevalence is not negligible, and may correlate with a prominent hemolytic pattern, a higher thrombotic risk, and a different therapy indication. PNH testing is particularly advisable in complex cases with inadequate response to AIHA-specific therapy. Cytokine patterns of PNH positive and negative AIHAs may give hints about the pathogenesis of highly hemolytic AIHA
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