Aqueous 2-methoxyethanol Reaction media: Synthesis of some 4,5-dihydro-pyrazole-1-carbaldehyde derivative

A novel N-formyl-2-pyrazoline derivative was synthesized by reaction of an α,β- unsaturated ketone with hydrazine hydrate and formic acid in aqueous 2-methoxyethanol reaction media. The Clean reaction conditions, simple workup procedure and short reaction time giving high yields of product are notable advantages of method. The structure of the title compound was established by IR, 1H NMR, 13C NMR and analytical data.

Synthesis and antibacterial activity of some new schiff bases and 2-Azetidinones containing iodohyydroxy biphenyl moiety

2-Hydroxy-5-phenylbenzaldehyde on iodination yielded 2-Hydroxy-3-iodo-5-phenylbenzaldehyde. This aldehyde on facile condensation with substituted aromatic amines in presence of catalytic amount of acetic acid to afford new series of Schiff bases. Further these Schiff bases on cyclocondensation reaction with chloroacetyl chloride afforded a biologically active 2-azetidinones derivatives. The structure of newly synthesized compounds characterized on the basis of elemental analysis and spectral data. The compounds prepared were tested against Xanthomonas citri, Escherichia coli, Erwinia carotovora and Bacillus subtilis. Some of these compounds showed potential antibacterial activity

Solvent-free, Environmentally Benign Syntheses of Some Imines and Antioxidant Activity

Environmentally benign, economically feasible, and solvent-free syntheses of series of imines by the condensation of a substituted hydroxynaphthyl ketone with several substituted iodoanilines under grinding approach are described. Imines were further tested for antioxidant activity; most of them show moderate activity. DOI: http://dx.doi.org/10.17807/orbital.v7i3.60

Irradiation of Tungsten Light: A Useful Energy Source for Synthesis of 4,5-Dihydro-pyrazole-1-carbaldehyde Derivatives

In the present communication, reported the easy, convenient route for the synthesis of N-formyl pyrazolines from α, β-unsaturated ketone. The aqueous 2-methoxyethanol was used as reaction media for the synthesis of titled compounds. All synthesized compounds were confirmed on the basis of IR, 1H NMR, 13C NMR and CHN analysis. DOI: http://dx.doi.org/10.17807/orbital.v9i4.1010  </p

2-Methoxyethanol as an alternative reaction solvent for the synthesis of 1,5-benzodiazepines under microwave irradiation

An improved condensation reaction between substituted 2’-hydroxychalcones and o-phenylenediamine using piperidine in 2-methoxyetahnol as an efficient and alternative reaction medium. The clean reaction conditions, easy work up, time saving and higher yields are notable advantages of present method.</div

Microwave Assisted Synthesis and Antimicrobial Study of Some Novel 2-Azetidinones Derived from 2-(1-Phenylimino-ethyl)-naphthalen-1-ol

Several substituted 2‐azetidinone derivatives 2a-q have been synthesized from halogenohydroxy substituted imines 1a-q under microwave irradiation technique. The reactions were carried out using 2-methoxyethanol as an efficient reaction media to afford high yield of product. The structures of newly synthesized compounds have been established on the basis of elemental analysis, IR, 1H NMR, 13C NMR, GC-MS and elemental data. Further, all newly synthesized compounds were screened for their in vitro antimicrobial activity. The antifungal and antibacterial effects of the tested compounds are due to their molecular structure and substituent present. DOI: http://dx.doi.org/10.17807/orbital.v11i3.1393</p

Solvent-free, Environmentally Benign Syntheses of Some Imines and Antioxidant Activity

Environmentally benign, economically feasible, and solvent-free syntheses of series of imines by the condensation of a substituted hydroxynaphthyl ketone with several substituted iodoanilines under grinding approach are described. Imines were further tested for antioxidant activity; most of them show moderate activity. DOI: http://dx.doi.org/10.17807/orbital.v7i3.608 </p