Material Dependence of the Wire-Particle Casimir Interaction

We study the Casimir interaction between a metallic cylindrical wire and a metallic spherical particle by employing the scattering formalism. At large separations, we derive the asymptotic form of the interaction. In addition, we find the interaction between a metallic wire and an isotropic atom, both in the non-retarded and retarded limits. We identify the conditions under which the asymptotic Casimir interaction does not depend on the material properties of the metallic wire and the particle. Moreover, we compute the exact Casimir interaction between the particle and the wire numerically. We show that there is a complete agreement between the numerics and the asymptotic energies at large separations. For short separations, our numerical results show good agreement with the proximity force approximation

Collective charge fluctuations and Casimir interactions for quasi one-dimensional metals

We investigate the Casimir interaction between two parallel metallic cylinders and between a metallic cylinder and plate. The material properties of the metallic objects are implemented by the plasma, Drude and perfect metal model dielectric functions. We calculate the Casimir interaction numerically at all separation distances and analytically at large separations. The large-distance asymptotic interaction between one plasma cylinder parallel to another plasma cylinder or plate does not depend on the material properties, but for a Drude cylinder it depends on the dc conductivity $\sigma$. At intermediate separations, for plasma cylinders the asymptotic interaction depends on the plasma wave length $\lambda_{\rm p}$ while for Drude cylinders the Casimir interaction can become independent of the material properties. We confirm the analytical results by the numerics and show that at short separations, the numerical results approach the proximity force approximation

Universality versus material dependence of fluctuation forces between metallic wires

We calculate the Casimir interaction between two parallel wires and between a wire and a metall plate. The dielectric properties of the objects are described by the plasma, Drude and perfect metal models. We find that at asymptotically large separation interactions involving plasma wires and/or plates are independent of the material properties, but depend on the dc conductivity $\sigma$ for Drude wires. Counterintuitively, at intermediate separations the interaction involving Drude wires can become independent of $\sigma$. At smaller separations, we compute the interaction numerically and observe an approach to the proximity approximation

Quantum and thermal Casimir interaction between a sphere and a plate: Comparison of Drude and plasma models

We calculate the Casimir interaction between a sphere and a plate, both described by the plasma model, the Drude model, or generalizations of the two models. We compare the results at both zero and finite temperatures. At asymptotically large separations we obtain analytical results for the interaction that reveal a non-universal, i.e., material dependent interaction for the plasma model. The latter result contains the asymptotic interaction for Drude metals and perfect reflectors as different but universal limiting cases. This observation is related to the screening of a static magnetic field by a London superconductor. For small separations we find corrections to the proximity force approximation (PFA) that support correlations between geometry and material properties that are not captured by the Lifshitz theory. Our results at finite temperatures reveal for Drude metals a non-monotonic temperature dependence of the Casimir free energy and a negative entropy over a sizeable range of separations.Comment: 11 pages, 5 figure

Elastic Lattice Polymers

We study a model of "elastic" lattice polymer in which a fixed number of monomers $m$ is hosted by a self-avoiding walk with fluctuating length $l$. We show that the stored length density $\rho_m = 1 - /m$ scales asymptotically for large $m$ as $\rho_m=\rho_\infty(1-\theta/m + ...)$, where $\theta$ is the polymer entropic exponent, so that $\theta$ can be determined from the analysis of $\rho_m$. We perform simulations for elastic lattice polymer loops with various sizes and knots, in which we measure $\rho_m$. The resulting estimates support the hypothesis that the exponent $\theta$ is determined only by the number of prime knots and not by their type. However, if knots are present, we observe strong corrections to scaling, which help to understand how an entropic competition between knots is affected by the finite length of the chain.Comment: 10 page

Prevalence of ESBLs in Acinetobacter baumannii isolated from intensive care unit (ICU) of Ghaem hospital, Mashhad, Iran

Acinetobacter baumannii is an important opportunistic pathogen that mainly infects critically patients in intensive care units (ICU). The production of plasmid-mediated extended-spectrum b-lactamases (ESBLs) is one of the most important mechanisms of resistance against b-lactam antibiotics. This study aimed to evaluate the prevalence of ESBLs in A. baumannii isolated from ICU of Ghaem hospital, Mashhad, Iran. A total of 140 A. baumannii isolates recovered from hospitalized patients in ICU of Ghaem hospital in Mashhad city from December 2014 to March 2015. Identification of A. baumannii isolates carried out using biochemical laboratory methods and then confirmed by OXA-51 PCR screening. Susceptibility testing performed using disk diffusion (Kirby-Bauer) method as recommended by CLSI guidelines. A. baumannii isolates screened for production of ESBLs using combination disk test. blaPER, blaGES, blaTEM, blaSHV, blaCTX, blaVEB and blaOXA-10 beta-lactamase genes detected using conventional PCR. The most antibacterial resistance was against cefuroxime (­99.3%) and colistin was the most effective antibiotic. None of the isolates were ESBL producer by combination disk test. However, results of PCR revealed that the prevalence of blaPER, blaGES and blaTEM genes were 7.1%, 4.3% and 27.1%, respectively. blaCTX, blaVEB, and blaOXA-10 were not found in any of isolates. According to the results, the high resistance was seen against selected antibiotics and the phenotypic tests are not sufficient alone for determination of ESBLs producer of A. baumannii isolates. So, molecular tests are also necessary for detection of these enzymes

Thinning of superfluid films below the critical point

Experiments on $^4$He films reveal an attractive Casimir-like force at the bulk $\lambda$-point, and in the superfluid regime. Previous work has explained the magnitude of this force at the $\lambda$ transition and deep in the superfluid region but not the substantial attractive force immediately below the $\lambda$-point. Utilizing a simple mean-field calculation renormalized by critical fluctuations we obtain an effective Casimir force that is qualitatively consistent with the scaling function $\vartheta$ obtained by collapse of experimental data.Comment: 4 page

Bone health in patients with multiple sclerosis relapses

OBJECTIVES: To evaluate the bone health and vitamin D levels of a cohort of patients with relapses of multiple sclerosis (MS) and to propose an algorithm for the management of bone health in this patient group. METHODS: We prospectively studied 56 consecutive patients from our acute relapse clinic. 3 patients were excluded from analysis as they were not deemed to have experienced an acute MS relapse. Bone health was assessed with vitamin D levels and Dual Energy X-ray Absorptiometry (DEXA) scanning (10 patients failed to attend for DEXA). Statistical analyses were used to compare groups and identify predictive variables. A review of the literature led to a proposed management protocol. RESULTS: Pre-relapse the baseline EDSS was ≤6.5 in all subjects, and <4.0 in the majority (66%). Most received corticosteroids. 51% had low bone mineral density (BMD) as defined by a T-score less than −1.0 on DEXA scanning. Three were osteoporotic (T-score less than −2.5). Thirty one of fifty (62%) subjects were Vitamin D deficient (25(OH)D less than 50 nmol/L). A range of variables, including previous corticosteroid usage, were not significantly predictive of reduced BMD. CONCLUSIONS: There was a high frequency of both low BMD and Vitamin D deficiency in this cohort of relatively young and largely ambulatory patients experiencing MS relapses. Current tools, such as the WHO FRAX algorithm, are inadequate in assessing bone status and fracture risk in this patient group, predominantly as they are focused on older age groups. We propose a simple clinical management algorithm

Knot localization in adsorbing polymer rings

We study by Monte Carlo simulations a model of knotted polymer ring adsorbing onto an impenetrable, attractive wall. The polymer is described by a self-avoiding polygon (SAP) on the cubic lattice. We find that the adsorption transition temperature, the crossover exponent $\phi$ and the metric exponent $\nu$, are the same as in the model where the topology of the ring is unrestricted. By measuring the average length of the knotted portion of the ring we are able to show that adsorbed knots are localized. This knot localization transition is triggered by the adsorption transition but is accompanied by a less sharp variation of the exponent related to the degree of localization. Indeed, for a whole interval below the adsorption transition, one can not exclude a contiuous variation with temperature of this exponent. Deep into the adsorbed phase we are able to verify that knot localization is strong and well described in terms of the flat knot model.Comment: 27 pages, 10 figures. Submitter to Phys. Rev.

Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms.

Because of the high costs associated with ascertainment of families, most linkage studies of Bipolar I disorder (BPI) have used relatively small samples. Moreover, the genetic information content reported in most studies has been less than 0.6. Although microsatellite markers spaced every 10 cM typically extract most of the genetic information content for larger multiplex families, they can be less informative for smaller pedigrees especially for affected sib pair kindreds. For these reasons we collaborated to pool family resources and carried out higher density genotyping. Approximately 1100 pedigrees of European ancestry were initially selected for study and were genotyped by the Center for Inherited Disease Research using the Illumina Linkage Panel 12 set of 6090 single-nucleotide polymorphisms. Of the ~1100 families, 972 were informative for further analyses, and mean information content was 0.86 after pruning for linkage disequilibrium. The 972 kindreds include 2284 cases of BPI disorder, 498 individuals with bipolar II disorder (BPII) and 702 subjects with recurrent major depression. Three affection status models (ASMs) were considered: ASM1 (BPI and schizoaffective disorder, BP cases (SABP) only), ASM2 (ASM1 cases plus BPII) and ASM3 (ASM2 cases plus recurrent major depression). Both parametric and non-parametric linkage methods were carried out. The strongest findings occurred at 6q21 (non-parametric pairs LOD 3.4 for rs1046943 at 119 cM) and 9q21 (non-parametric pairs logarithm of odds (LOD) 3.4 for rs722642 at 78 cM) using only BPI and schizoaffective (SA), BP cases. Both results met genome-wide significant criteria, although neither was significant after correction for multiple analyses. We also inspected parametric scores for the larger multiplex families to identify possible rare susceptibility loci. In this analysis, we observed 59 parametric LODs of 2 or greater, many of which are likely to be close to maximum possible scores. Although some linkage findings may be false positives, the results could help prioritize the search for rare variants using whole exome or genome sequencing