Immunohistochemical expression of latent membrane protein 1 (LMP1) and p53 in nasopharyngeal carcinoma: Moroccan experience

BACKGROUND: Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor intimately associated with Epstein-Barr virus (EBV). NPC is a characteristic tumor displaying epidemiological, genetic and regional distribution properties that makes it unique by its natural behavior. OBJECTIVES: To assess the expression pattern of LMP1 and p53 proteins in the different histological types of NPC in a sample of the Moroccan population and to define any association between the expression of those proteins with the sex, the age and the histological types of NPC. METHODS: Archival formalin-fixed, paraffin-embedded NPC biopsies were evaluated in 23 Moroccan patients for the presence of LMP1 and p53 using immunohistochemistry (IHC). RESULTS: No LMP1 expression was observed whereas 8 of 23 cases (34. 7%) had detectable p53 protein in the nuclei of tumor cells. After statistical analysis according to the Fisher's exact probability test, no significant association between p53 expression and histological type, age and sex distributions was demonstrated (p>0.05). CONCLUSION: This study confirms that p53 overexpression is present in a subset of Moroccan NPC patients. Our results are consistent with those reported by other studies concerning the same NPC endemic risk area and provide original data concerning Morocco

Intra-abdominal desmoplastic small round cell tumors: US and CT features

Intra-abdominal desmoplastic small round cell tumor is an extremely rare entity with poor prognosis. The authors report a case of intra-abdominal desmoplastic small round cell tumor and describe the imaging and pathologic features of the tumor

Cas Clinique Une tumeur rénale inhabituelle : carcinome tubulomucineux

Le carcinome tubulo-mucineux et fusiforme de bas grade de malignité est une tumeur rare décrite comme entité nouvelle dans la classifi cation OMS 2004. Nous rapportons le cas d\'une femme de 42 ans qui s\'est présentée à la consultation pour des lombalgies chroniques gauche et chez qui l\'examen tomodensitométrique a révélé la présence d\'une masse rénale gauche de 10 cm de grand axe. La patiente a été traitée par néphrectomie élargie gauche dont l\'examen macroscopique a montré la présence d\'une tumeur médio-rénale bien limitée de 8,2 cm de grand axe d\'aspect charnu avec des remaniements hémorragiques et nécrotiques. L\'évaluation microscopique a confi rmé qu\'il s\'agissait d\'un carcinome tubulo-mucineux et à cellules fusiformes aux contours non infi ltrants sans envahissement du hile. L\'étude immunohistochimique a révélé une positivité à la CK (KL1), CK7, CK20, EMA, vimentine et CD15 et une négativité au CD10. Le but de notre travail est de rapporter un cas de cette entité rare dont la reconnaissance par les pathologistes et les cliniciens est primordiale, en raison de son évolution tout à fait favorable. Keywords: Rein, carcinome rénal, tubulo-mucineux, fusiforme, bas grade, immunohistochimieAfrican Journal Of Urology Vol.14 (3) 2007: pp. 179-18

Onychomatricome.

Journal Articleinfo:eu-repo/semantics/publishe

Immunohistochemical expression of latent membrane protein 1 (LMP1) and p53 in nasopharyngeal carcinoma: Moroccan experience

Background: Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor intimately associated with Epstein-Barr virus (EBV). NPC is a characteristic tumor displaying epidemiological, genetic and regional distribution properties that makes it unique by its natural behavior. Objectives: To assess the expression pattern of LMP1 and p53 proteins in the different histological types of NPC in a sample of the Moroccan population and to define any association between the expression of those proteins with the sex,the age and the histological types of NPC. Methods: Archival formalin-fixed, paraffin-embedded NPC biopsies were evaluated in 23 Moroccan patients for the presence of LMP1 and p53 using immunohistochemistry (IHC). Results: No LMP1 expression was observed whereas 8 of 23 cases (34. 7%) had detectable p53 protein in the nuclei of tumor cells. After statistical analysis according to the Fisher’s exact probability test, no significant association between p53 expression and histological type, age and sex distributions was demonstrated (p>0.05). Conclusion: This study confirms that p53 overexpression is present in a subset of Moroccan NPC patients. Our results are consistent with those reported by other studies concerning the same NPC endemic risk area and provide original data concerning Morocco

Carcinome epidermoïde du bassinet révélé par une pyonéphrose :A propos d\'un cas et revue de la littérature

Le carcinome épidermoïde du bassinet est une tumeur rare et grave. Elle survient principalement chez des patients au long passé de calculs et d\'infections urinaires. Nous rapportons le cas d\'un jeune patient âgé de 45 ans suivi pour lithiases urinaires et présentant un rein détruit et douloureux sur calcul coralliforme. Le diagnostic préopératoire a évoqué une pyonéphrose. La néphrectomie réalisée, l\'étude histologique a conclu un carcinome épidermoïde du bassinet infiltrant le rein. Le patient est décédé 3 mois après l\'intervention. A travers l\'étude de cette observation et une revue de la littérature, nous discutons les aspects étiopathogéniques, anatomopathologiques, et thérapeutiques de cette affection dont le diagnostic est histologique et le traitement reste chirurgical avec un pronostic sombre. Africain Journal of Urology Vol. 14 (2) 2008: pp. 123-12

Primary pericardial synovial sarcoma: A case report and literature review

Primary pericardial synovial sarcoma is extremely rare, with few published cases in the literature. We report the case of an adolescent aged 13 years with primary pericardial synovial sarcoma discovered during tamponade, confirmed by molecular biology, and for whom treatment combined radiosurgery and adjuvant chemotherapy. The particularity of the case we are reporting stems from the young age of our patient (13 years) as well as the duration of remission, which is quite long (21 months) prior to a superior mediastinal relapse compared to cases reported in the literature.\ud Learning objective: Synovial sarcoma is difficult to diagnose and has a poor prognosis. Here, a 13-year-old diagnosed with primary pericardial synovial sarcoma was treated with combined radiosurgery and adjuvant chemotherapy leading to continuous remission for 21 months. This regimen could be used to successfully manage future patients. Molecular biology is useful in the diagnosis of synovial sarcoma through the identification of t(X;18) translocation in atypical locations as in the present case